Review paper
Entecavir Induced Severe Myopathy: An Uncommon Side Effect
Volume: 2, Issue: 1, Pages: 15 - 17
Published: Apr 6, 2021
Abstract
Chronic Hepatitis B virus (HBV) infection is a chronic viral illness that affects millions of people around the world and can cause serious consequences such as hepatic failure and hepatocellular carcinoma.Entecavir, a guanosine nucleoside analog (NA), is a commonly used and generally safe therapeutic agent in HBV infection.In this paper, we aimed to present a case of chronic HBV that developed severe myopathy as an extremely rare side effect...
Paper Details
Title
Entecavir Induced Severe Myopathy: An Uncommon Side Effect
Published Date
Apr 6, 2021
Volume
2
Issue
1
Pages
15 - 17
References10
Other
# 1Ting‐Tsung Chang(NCKU: National Cheng Kung University)
24
# 2Robert G. Gish(CPMC: California Pacific Medical Center)
71
Last. David Apelian(GlobeImmune (United States))
15
Entecavir is a potent and selective guanosine analogue with significant activity against hepatitis B virus (HBV).
Review paper
# 1Andrew R. Findlay(UCI: University of California, Irvine)
14
# 2Namita Goyal(UCI: University of California, Irvine)
32
Last. Tahseen Mozaffar(UCI: University of California, Irvine)
48
Polymyositis and dermatomyositis are inflammatory myopathies that differ in their clinical features, histopathology, response to treatment, and prognosis. Although their clinical pictures differ, they both present with symmetrical, proximal muscle weakness. Treatment relies mainly upon empirical use of corticosteroids and immunosuppressive agents. A deeper understanding of the molecular pathways that drive pathogenesis, careful phenotyping, and accurate disease classification will aid clinical r...
Review paper
# 1Vincenza Dolce(University of Bari Aldo Moro)
34
# 2Giuseppe Fiermonte(University of Bari Aldo Moro)
36
Last. John E. Walker(MRC: Medical Research Council)
100
The synthesis of DNA in mitochondria requires the uptake of deoxynucleotides into the matrix of the organelle. We have characterized a human cDNA encoding a member of the family of mitochondrial carriers. The protein has been overexpressed in bacteria and reconstituted into phospholipid vesicles where it catalyzed the transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. It did not transport dNMPs, NMPs, deoxynucleosides, nucleo...
Original paper
# 1Edward G. Bridges(Yale University)
17
# 2Zaoli Jiang(Yale University)
20
Last. Yung‐Chi Cheng(Yale University)
56
A protein fraction of mitochondria from human acute lymphocytic leukemia cells, which could be reconstituted into proteoliposomes to have dCTP transport activity, has been partially purified by hydroxyapatite and blue Sepharose chromatography. The dCTP transport activity in proteoliposomes was time-dependent and could be activated by Ca2+ and to a lesser extent by Mg2+. None of the other divalent cations tested could activate the transport activity. The K m
Original paper
Summary Background Results are conflicting with respect to the renal effects of anti‐viral agents used for hepatitis B virus infection. Aim To compare short and long‐term renal effects in real‐life settings and to determine risk factors for renal impairment during treatment. Methods 2221 treatment‐naïve patients were enrolled. Among these, 895 (302 lamivudine, 27 telbivudine, 282 entecavir, 273 tenofovir and 11 adefovir initiated patients) had ‘repeated measures’ of creatinine (baseline, 1st, 6t...
Review paper
# 1Thad Wilkins(GRU: Augusta University)
18
# 2Richard Sams(GRU: Augusta University)
6
Last. Mary A. Carpenter(GRU: Augusta University)
15
Hepatitis B virus (HBV) is a partly double-stranded DNA virus that causes acute and chronic liver infection. Screening for hepatitis B is recommended in pregnant women at their first prenatal visit and in adolescents and adults at high risk of chronic infection. Hepatitis B vaccination is recommended for medically stable infants weighing 2,000 g or more within 24 hours of birth, unvaccinated infants and children, and unvaccinated adults requesting protection from hepatitis B or who are at increa...
Original paper
# 1Xiaojing Zou(HUST: Huazhong University of Science and Technology)
24
# 2Xueqing Jiang(HUST: Huazhong University of Science and Technology)
14
Last. Dai-Shi Tian(Tongji Hospital)
3
With the extensive use of telbivudine, more and more studies reported its association with creatine kinase (CK) elevations and myopathy. However, clinical features of these adverse effects were poorly understood. The aim of the present study was to investigate the clinical features and risk factors of CK elevations and myopathy associated with telbivudine. The serum CK levels of 200 patients who were treated with telbivudine for chronic hepatitis B (CHB) between January 2007 and July 2010 were m...
Other
# 1Thomas Tu(USYD: University of Sydney)
20
# 2Mark W. Douglas(USYD: University of Sydney)
32
In this Special Issue, we have brought together a broad range of studies on hepatitis B virus (HBV) covering diagnosis, pathogenesis, monitoring, and treatment [...].
Original paper
# 1Kai Yuan(CJFH: China-Japan Friendship Hospital)
18
# 2Guochun Wang(CJFH: China-Japan Friendship Hospital)
26
Last. Xin Lü(CJFH: China-Japan Friendship Hospital)
44
Introduction: Entecavir, a nucleoside analog (NA), is effective for treatment of chronic hepatitis B virus (HBV) infection. Methods: We report the case of a patient we encountered with entecavir-associated myopathy. We also performed a literature review of myopathies associated with nucleoside analogs. Results: A 44-year-old man presented with a 3-month history of myalgia and progressive weakness. He had HBV infection and had received entecavir antiviral treatment for 5 years. Laboratory tests s...
Review paper
# 1Ergenekon Karagöz(Fatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi)
10
# 2Alpaslan Tanoğlu(GATA Haydarpaşa Eğitim Hastanesi)
15
Context: Quantitative hepatitis B surface antigen (qHBsAg) levels have been shown to assist the management of patients with chronic hepatitis B virus (HBV) infection and reflect the level of transcriptional activity of covalently closed circular DNA (cccDNA). It has been indicated the importance of co-operative use of qHBsAg and HBV-DNA for diagnosis and monitoring of CHB treatment. Evidence Acquisition: In order to achieve a comprehensive approach in HBsAg quantification, an extensive search wa...
1