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Proceedings of the National Academy of Sciences of the United States of America
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9.58
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140248
Papers 139202
1 page of 13.9k pages (139k results)
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Hua Wang2
Estimated H-index: 2
(Francis Crick Institute),
Alexander A. Fedorov40
Estimated H-index: 40
(Albert Einstein College of Medicine)
+ 7 AuthorsLuiz Pedro S. de Carvalho14
Estimated H-index: 14
(Francis Crick Institute)
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting for ∼1.3 million deaths in 2017. As part of the immune response to Mtb infection, macrophages produce metabolites with the purpose of inhibiting or killing the bacterial cell. Itaconate is an abundant host metabolite thought to be both an antimicrobial agent and a modulator of the host inflammatory response. However, the exact mode of act...
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Published on Feb 9, 2019in arXiv: Soft Condensed Matter
Joia Miller , Chaitanya Joshi + 4 AuthorsZvonimir Dogic31
Estimated H-index: 31
Membrane-mediated particle interactions depend both on the properties of the particles themselves and the membrane environment in which they are suspended. Experiments have shown that chiral rod-like inclusions dissolved in a colloidal membrane of opposite handedness assemble into colloidal rafts, which are finite-sized reconfigurable droplets consisting of a large but precisely defined number of rods. Here, we systematically tune the chirality of the background membrane, and find that in the ac...
Thomas Burgoyne (Imperial College London), John M. Heumann8
Estimated H-index: 8
(CU: University of Colorado Boulder)
+ 6 AuthorsPradeep K. Luther25
Estimated H-index: 25
(Imperial College London)
Striated muscle enables movement in all animals by the contraction of myriads of sarcomeres joined end to end by the Z-bands. The contraction is due to tension generated in each sarcomere between overlapping arrays of actin and myosin filaments. At the Z-band, actin filaments from adjoining sarcomeres overlap and are cross-linked in a regular pattern mainly by the protein α-actinin. The Z-band is dynamic, reflected by the 2 regular patterns seen in transverse section electron micrographs; the so...
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Xiaofeng Zhou (Stanford University), Jiarui Wang3
Estimated H-index: 3
(Stanford University)
+ 2 AuthorsLucy Shapiro72
Estimated H-index: 72
(Stanford University)
The cell cycle-regulated methylation state of Caulobacter DNA mediates the temporal control of transcriptional activation of several key regulatory proteins. Temporally controlled synthesis of the CcrM DNA methyltransferase and Lon-mediated proteolysis restrict CcrM to a specific time in the cell cycle, thereby allowing the maintenance of the hemimethylated state of the chromosome during the progression of DNA replication. We determined that a chromosomal DNA-based platform stimulates CcrM degra...
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Leo Ng1
Estimated H-index: 1
(NU: Northwestern University),
Thuy N. Vien5
Estimated H-index: 5
(NU: Northwestern University)
+ 1 AuthorsPaul G. DeCaen18
Estimated H-index: 18
(NU: Northwestern University)
The opening of voltage-gated ion channels is initiated by transfer of gating charges that sense the electric field across the membrane. Although transient receptor potential ion channels (TRP) are members of this family, their opening is not intrinsically linked to membrane potential, and they are generally not considered voltage gated. Here we demonstrate that TRPP2, a member of the polycystin subfamily of TRP channels encoded by the PKD2L1 gene, is an exception to this rule. TRPP2 borrows a bi...
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