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Proceedings of the National Academy of Sciences of the United States of America
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Competence allows bacteria to internalize exogenous DNA fragments for the acquisition of new phenotypes such as antibiotic resistance or virulence traits. In most streptococci, competence is regulated by ComRS signaling, a system based on the mature ComS pheromone (XIP), which is internalized to activate the (R)RNPP-type ComR sensor by triggering dimerization and DNA binding. Cross-talk analyses demonstrated major differences of selectivity between ComRS systems and raised questions concerning t...
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It is well known that society faces a conundrum of dealing with antibiotic drug resistance and future deadly bacteria and infections. These battles involve the rise of methicillin-resistant Staphylococcus aureus (1, 2) in hospitals and the general treatment of infections in the population. The process of developing unique and new therapeutics is very active in pharma and research laboratories, and it requires both the identification of new targets and possibly taking a different approach, away f...
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#1Steven J. Mileto (Monash University)H-Index: 2
#2Thierry Jarde (Monash University)H-Index: 15
Last. John A. Shupe (VUMC: Vanderbilt University Medical Center)
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Gastrointestinal infections often induce epithelial damage that must be repaired for optimal gut function. While intestinal stem cells are critical for this regeneration process [R. C. van der Wath, B. S. Gardiner, A. W. Burgess, D. W. Smith, PLoS One 8, e73204 (2013); S. Kozar et al., Cell Stem Cell 13, 626–633 (2013)], how they are impacted by enteric infections remains poorly defined. Here, we investigate infection-mediated damage to the colonic stem cell compartment and how this affects epit...
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Range expansions lead to distinctive patterns of genetic variation in populations, even in the absence of selection. These patterns and their genetic consequences have been well studied for populations advancing through successive short-ranged migration events. However, most populations harbor some degree of long-range dispersal, experiencing rare yet consequential migration events over arbitrarily long distances. Although dispersal is known to strongly affect spatial genetic structure during ra...
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#1Matthew Hackbart (LUC: Loyola University Chicago)H-Index: 1
#2Xufang Deng (LUC: Loyola University Chicago)H-Index: 11
Last. Susan C. Baker (LUC: Loyola University Chicago)H-Index: 39
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Coronaviruses (CoVs) are positive-sense RNA viruses that can emerge from endemic reservoirs and infect zoonotically, causing significant morbidity and mortality. CoVs encode an endoribonuclease designated EndoU that facilitates evasion of host pattern recognition receptor MDA5, but the target of EndoU activity was not known. Here, we report that EndoU cleaves the 5′-polyuridines from negative-sense viral RNA, termed PUN RNA, which is the product of polyA-templated RNA synthesis. Using a virus co...
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#1Iuliia Polina (Dal: Dalhousie University)H-Index: 7
#2Hailey J. Jansen (Dal: Dalhousie University)H-Index: 5
Last. Sara A. Rafferty (Dal: Dalhousie University)H-Index: 6
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Atrial fibrillation (AF) is prevalent in diabetes mellitus (DM); however, the basis for this is unknown. This study investigated AF susceptibility and atrial electrophysiology in type 1 diabetic Akita mice using in vivo intracardiac electrophysiology, high-resolution optical mapping in atrial preparations, and patch clamping in isolated atrial myocytes. qPCR and western blotting were used to assess ion channel expression. Akita mice were highly susceptible to AF in association with increased P-w...
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