Review paper
The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals
Volume: 98, Issue: 5, Pages: 2284 - 2288
Published: Feb 20, 2001
Abstract
The synthesis of DNA in mitochondria requires the uptake of deoxynucleotides into the matrix of the organelle. We have characterized a human cDNA encoding a member of the family of mitochondrial carriers. The protein has been overexpressed in bacteria and reconstituted into phospholipid vesicles where it catalyzed the transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. It did...
Figures & Tables
Fig. 1. Sequence of a human cDNA and the encoded DNC. Amino acids are numbered f...
Fig. 2. Purification of DNC by Ni1-agarose affinity chromatography. Proteins wer...
Fig. 3. Time course of dATPyADP exchange and substrate specificity of human DNC....
Fig. 4. Expression of human DNC in various tissues. Analysis of total RNA from h...
Fig. 5. Folding of the DNC in the inner membranes of mitochondria. The topograph...
Paper Details
Title
The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals
Published Date
Feb 20, 2001
Volume
98
Issue
5
Pages
2284 - 2288
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