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Journal of Biological Chemistry
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#1Soumi Ghosh (UM: University of Michigan)H-Index: 1
#2E. Neil G. Marsh (UM: University of Michigan)H-Index: 35
Viperin plays an important and multifaceted role in the innate immune response to viral infection. Viperin is also notable as one of very few radical SAM-dependent enzymes present in higher animals; however, the enzyme appears broadly conserved across all kingdoms of life, which suggests that it represents an ancient defense mechanism against viral infections. Although viperin was discovered some 20 years ago, only recently was the enzyme's structure determined and its catalytic activity elucida...
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#1Flaviana Di Lorenzo (University of Naples Federico II)H-Index: 10
Last. José-Enrique Ruiz-Sainz (University of Seville)H-Index: 3
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Rhizobia are soil bacteria that form important symbiotic associations with legumes, and rhizobial surface polysaccharides, such as K-antigen polysaccharide (KPS) and lipopolysaccharide (LPS), might be important for symbiosis. Previously, we obtained a mutant of Sinorhizobium fredii HH103, rkpA, that does not produce KPS, a homopolysaccharide of a pseudaminic acid derivative, but whose LPS electrophoretic profile was indistinguishable from that of the wild-type strain. Also, we previously demonst...
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#1Yasmin A. Kadry (Yale University)H-Index: 1
#2Eesha M Maisuria (Yale University)
Last. David A. Calderwood (Yale University)H-Index: 46
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The integrin family of transmembrane adhesion receptors coordinate complex signaling networks that control the ability of cells to sense and communicate with the extracellular environment. Kindlin proteins are a central cytoplasmic component of these networks, directly binding integrin cytoplasmic domains and mediating interactions with cytoskeletal and signaling proteins. The physiological importance of kindlins is well established, but how the scaffolding functions of kindlins are regulated at...
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#1Melanie Stammers (Babraham Institute)
#2Izabella Niewczas (Babraham Institute)H-Index: 6
Last. Jonathan Clark (Babraham Institute)H-Index: 14
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Collagen I is a major tendon protein whose polypeptide chains are linked by covalent cross-links. It is unknown how the cross-linking contributes to the mechanical properties of tendon or whether cross-linking changes in response to stretching or relaxation. Since their discovery, imine bonds within collagen have been recognized as being important in both cross-link formation and collagen structure. They are often described as acidic or thermally labile, but no evidence is available from direct ...
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#1Shalinee Jha (Graz University of Technology)H-Index: 1
#2Ulrike Taschler (University of Graz)H-Index: 15
Last. Tobias Madl (Medical University of Graz)H-Index: 27
view all 13 authors...
Dipeptidyl peptidase 3 (DPP3) is a zinc-dependent hydrolase involved in degrading oligopeptides with 4-12 amino acid residues. It has been associated with several pathophysiological processes, including blood pressure regulation, pain signaling, and cancer cell defense against oxidative stress. However, the physiological substrates and the cellular pathways that are potentially targeted by DPP3 to mediate these effects remain unknown. Here, we show that global DPP3 deficiency in mice (DPP3-/-) a...
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#1Wen Liu (NU: Nanjing University)H-Index: 12
#2Ye Yin (Nanjing Medical University)H-Index: 1
Last. Xiangbao Meng (PKU: Peking University)H-Index: 13
view all 15 authors...
Chronic low-grade inflammation plays an important role in the pathogenesis of type 2 diabetes. Src homology 2 domain-containing tyrosine phosphatase-2 (SHP2) has been reported to play diverse roles in different tissues during the development of metabolic disorders. We previously reported that SHP2 inhibition in macrophages results in increased cytokine production. Here, we investigated the association between SHP2 inhibition in macrophages and the development of metabolic diseases. Unexpectedly,...
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#1Salim Abdisalaam (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
#2Souparno Bhattacharya (UTSW: University of Texas Southwestern Medical Center)H-Index: 9
Last. Asaithamby Aroumougame (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
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Defective DNA damage response (DDR) signaling is a common mechanism that initiates and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR signaling, genomic instability, and cellular senescence, but the links among these events remains unclear. Here, using an array of biochemical and imaging techniques, including a highly regulatable CRISPR/Cas9 strategy to induce DNA double-strand breaks specifically in the telomeres, chromatin immunoprecipitation, telomere immuno...
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#1Rachel Jaber Chehayeb (Yale University)
#2Jessica K. Wang (Yale University)H-Index: 1
Last. Titus J. Boggon (Yale University)H-Index: 47
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The Src homology 2 (SH2) domain has a highly conserved architecture that recognizes linear phosphotyrosine motifs and is present in a wide range of signaling pathways across different evolutionary taxa. A hallmark of SH2 domains is the arginine residue in the conserved "FLVR" motif that forms a direct salt bridge with bound phosphotyrosine. Here, we solve the X-ray crystal structures of the C-terminal SH2 domain of p120RasGAP (RASA1) in its apo and peptide-bound form. We find that the arginine r...
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#1Chihiro Hayashi (Kyushu University)H-Index: 1
#2Erika Miyazaki (Kyushu University)H-Index: 1
Last. Tsutomu Katayama (Kyushu University)H-Index: 34
view all 5 authors...
The DNA replication protein DnaA in Escherichia coli constructs higher-order complexes on the origin, oriC, to unwind this region. DnaB helicase is loaded onto unwound oriC via interactions with the DnaC loader and the DnaA complex. The DnaB-DnaC complex is recruited to the DnaA complex via stable binding of DnaB to DnaA domain I. The DnaB-DnaC complex is then directed to unwound oriC via a weak interaction between DnaB and DnaA domain III. Previously, we showed that Phe-46 in DnaA domain I bind...
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#1Selwyn S. Jayakar (Harvard University)H-Index: 9
#2David C. Chiara (Harvard University)H-Index: 24
Last. Jonathan B. Cohen (Harvard University)H-Index: 51
view all 7 authors...
Allopregnanolone (3α5α-P), pregnanolone, and their synthetic derivatives are potent positive allosteric modulators (PAMs) of GABAA receptors (GABAARs) with in vivo anesthetic, anxiolytic, and anti-convulsant effects. Mutational analyses, photoaffinity labeling, and structural studies have provided evidence for intersubunit and intrasubunit steroid-binding sites in the GABAAR transmembrane domain, but revealed only little definition of their binding properties. Here, we identified steroid-binding...
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