Review paper
The mechanism of Hsp90-induced oligomerizaton of Tau
Abstract
Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer's disease with Tau oligomers suspected as the most toxic agent. Tau is a client of the molecular chaperone Hsp90, although it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is...
Paper Details
Title
The mechanism of Hsp90-induced oligomerizaton of Tau
Published Date
Mar 13, 2020
Journal
Volume
6
Issue
11
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