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Magdalena Wawrzyniuk
Utrecht University
FibrilHsp90Chaperone (protein)Alzheimer's diseaseAmyloid
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Publications 3
Newest
#1Sabrina Weickert (University of Konstanz)H-Index: 2
#2Magdalena Wawrzyniuk (UU: Utrecht University)
Last. Malte Drescher (University of Konstanz)H-Index: 23
view all 5 authors...
Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer’s disease with Tau oligomers suspected as the most toxic agent. Tau is a client of the molecular chaperone Hsp90, although it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, although “paper clip...
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#1Björn M. Burmann (University of Basel)H-Index: 10
#2Juan GerezH-Index: 12
Last. Sebastian Hiller (University of Basel)H-Index: 28
view all 15 authors...
Neurodegeneration in patients with Parkinson’s disease is correlated with the occurrence of Lewy bodies—intracellular inclusions that contain aggregates of the intrinsically disordered protein α-synuclein1. The aggregation propensity of α-synuclein in cells is modulated by specific factors that include post-translational modifications2,3, Abelson-kinase-mediated phosphorylation4,5 and interactions with intracellular machineries such as molecular chaperones, although the underlying mechanisms are...
4 CitationsSource
#1Sabrina Weickert (University of Konstanz)H-Index: 2
#2Magdalena Wawrzyniuk (UU: Utrecht University)
Last. Malte Drescher (University of Konstanz)H-Index: 23
view all 5 authors...
Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimers disease with Tau oligomers suspected as the most toxic agent. Tau is a client of Hsp90, though it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, though paper-clip-shaped by long-range contacts...
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