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#1Jeffery A. Aguiar (INL: Idaho National Laboratory)H-Index: 16
#2Matthew L. Gong (UofU: University of Utah)H-Index: 1
Last.Brandon D. Miller (INL: Idaho National Laboratory)H-Index: 12
view all 5 authors...
While machine learning has been making enormous strides in many technical areas, it is still massively underused in transmission electron microscopy. To address this, a convolutional neural network model was developed for reliable classification of crystal structures from small numbers of electron images and diffraction patterns with no preferred orientation. Diffraction data containing 571,340 individual crystals divided among seven families, 32 genera, and 230 space groups were used to train t...
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#1Jessica Johnston (University of Sheffield)H-Index: 2
#2Adrienn Angyal (University of Sheffield)H-Index: 5
Last.Endre Kiss-Toth (University of Sheffield)H-Index: 24
view all 15 authors...
Macrophages drive atherosclerotic plaque progression and rupture; hence, attenuating their atherosclerosis-inducing properties holds promise for reducing coronary heart disease (CHD). Recent studies in mouse models have demonstrated that Tribbles 1 (Trib1) regulates macrophage phenotype and shows that Trib1 deficiency increases plasma cholesterol and triglyceride levels, suggesting that reduced TRIB1 expression mediates the strong genetic association between the TRIB1 locus and increased CHD ris...
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#2Christoph Gammer (Austrian Academy of Sciences)H-Index: 7
Last.H. Peter Karnthaler (University of Vienna)H-Index: 4
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We demonstrate electrodeposition as a synthesis method for fabrication of Al coatings, up to 10 μm thick, containing a high density of genuine growth twins. This has not been expected since the twin boundary energy of pure Al is very high. TEM methods were used to analyze deposited Al and its nanoscaled twins. DFT methods confirmed that the influence of the substrate is limited to the layers close to the interface. Our findings are different from those achieved by sputtering of Al coatings restr...
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#1Rui Li (CUHK: The Chinese University of Hong Kong)H-Index: 7
#2Sien Lin (CUHK: The Chinese University of Hong Kong)H-Index: 14
Last.Liming BianH-Index: 23
view all 9 authors...
Noncanonical Wnt signaling in stem cells is essential to numerous developmental events. However, no prior studies have capitalized on the osteoinductive potential of noncanonical Wnt ligands to functionalize biomaterials in enhancing the osteogenesis and associated skeleton formation. Here, we investigated the efficacy of the functionalization of biomaterials with a synthetic Wnt5a mimetic ligand (Foxy5 peptide) to promote the mechanosensing and osteogenesis of human mesenchymal stem cells by ac...
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#1Zhe He (A&M: Texas A&M University)H-Index: 2
#2Zehua Han (A&M: Texas A&M University)H-Index: 1
Last.Marlan O. Scully (A&M: Texas A&M University)H-Index: 76
view all 11 authors...
Monitoring and controlling the neutral and charged excitons (trions) in two-dimensional (2D) materials are essential for the development of high-performance devices. However, nanoscale control is challenging because of diffraction-limited spatial resolution of conventional far-field techniques. Here, we extend the classical tip-enhanced photoluminescence based on tip-substrate nanocavity to quantum regime and demonstrate controlled nano-optical imaging, namely, tip-enhanced quantum plasmonics. I...
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#1Dafni Chrysanthi Delivoria (NTUA: National Technical University of Athens)H-Index: 3
#2Sean Chia (University of Cambridge)H-Index: 6
Last.Georgios SkretasH-Index: 12
view all 11 authors...
Protein misfolding and aggregation are associated with a many human disorders, including Alzheimer’s and Parkinson’s diseases. Toward increasing the effectiveness of early-stage drug discovery for these conditions, we report a bacterial platform that enables the biosynthesis of molecular libraries with expanded diversities and their direct functional screening for discovering protein aggregation inhibitors. We illustrate this approach by performing, what is to our knowledge, the largest function...
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#1Colin J. Boyle (Imperial College London)H-Index: 3
#2Magdalena Plotczyk (Imperial College London)
Last.Claire A. Higgins (Imperial College London)H-Index: 12
view all 8 authors...
Plantar skin on the soles of the feet has a distinct morphology and composition that is thought to enhance its tolerance to mechanical loads, although the individual contributions of morphology and composition have never been quantified. Here, we combine multiscale mechanical testing and computational models of load bearing to quantify the mechanical environment of both plantar and nonplantar skin under load. We find that morphology and composition play distinct and complementary roles in planta...
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#1Martijn van Galen (WUR: Wageningen University and Research Centre)
#2Ruben Higler (WUR: Wageningen University and Research Centre)H-Index: 5
Last.Joris Sprakel (WUR: Wageningen University and Research Centre)H-Index: 22
view all 3 authors...
Assembling large numbers of molecular building blocks into functional nanostructures is no trivial task. It relies on guiding building blocks through complex energy landscapes shaped by synergistic and antagonistic supramolecular interactions. In nature, the use of molecular templates is a potent strategy to navigate the process to the desired structure with high fidelity. Yet, nature’s templating strategy remains to be fully exploited in man-made nanomaterials. Designing effective template-guid...
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#1Dong Hyun Jo (Seoul National University Hospital)H-Index: 13
#2Dong Woo SongH-Index: 1
Last.Jungmin Lee (Handong Global University)H-Index: 4
view all 13 authors...
Leber congenital amaurosis (LCA), one of the leading causes of childhood-onset blindness, is caused by autosomal recessive mutations in several genes including RPE65. In this study, we performed CRISPR-Cas9–mediated therapeutic correction of a disease-associated nonsense mutation in Rpe65 in rd12 mice, a model of human LCA. Subretinal injection of adeno-associated virus carrying CRISPR-Cas9 and donor DNA resulted in >1% homology-directed repair and ~1.6% deletion of the pathogenic stop codon in ...
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#1Karen E. Alley (College of Wooster)
#2Theodore A. Scambos (CIRES: Cooperative Institute for Research in Environmental Sciences)H-Index: 48
Last.Nicholas Holschuh (UW: University of Washington)H-Index: 4
view all 4 authors...
Floating ice shelves of fast-flowing ice streams are prone to rift initiation and calving originating along zones of rapid shearing at their margins. Predicting future ice-shelf destabilization under a warming ocean scenario, with the resultant reduced buttressing, faster ice flow, and sea-level rise, therefore requires an understanding of the processes that thin and weaken these shear margins. Here, we use satellite data to show that high velocity gradients result in surface troughs along the m...
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