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#2Grant T. GoddenH-Index: 4
Last. Taliesin J KinserH-Index: 1
view all 17 authors...
#1Dongxu He (Jiangnan University)H-Index: 9
#2Aiqin Mao (Jiangnan University)H-Index: 6
Last. Xin Ma (Jiangnan University)H-Index: 20
view all 9 authors...
Mammalian transient receptor potential (TRP) channels are major components of Ca2+ signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of herpes simplex virus type 1 (HSV-1) into cells. HSV-1–induced Ca2+ release and entry were dependent on Orai1, STIM1, and TRPC1. Inhibition of Ca2+ entry or knockdown of these proteins attenuated viral entry and infection. HSV-1 glycoprotein D interacted with the third ectodomain of TRPC1...
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#1Xin Zhou (CAS: Chinese Academy of Sciences)H-Index: 1
#2Zhong-Hai Li (CAS: Chinese Academy of Sciences)H-Index: 13
Last. Robert J. Stern (UTD: University of Texas at Dallas)H-Index: 71
view all 4 authors...
Understanding the conditions for forming new subduction zones at passive continental margins is important for understanding plate tectonics and the Wilson cycle. Previous models of subduction initiation (SI) at passive margins generally ignore effects due to the lateral transition from oceanic to continental lithosphere. Here, we use three-dimensional numerical models to study the possibility of propagating convergent plate margins from preexisting intraoceanic subduction zones along passive mar...
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#1Hirofumi Omori (Kobe University)
#2Miki Nishio (Kobe University)H-Index: 6
Last. Hiroki HikasaH-Index: 8
view all 18 authors...
Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common group of cancers in the world, and patients have a poor prognosis. Here, we present data indicating that YAP1 may be a strong driver of the onset and progression of oral SCC (OSCC), a major subtype of HNSCC. Mice with tongue-specific deletion of Mob1a/b and thus endogenous YAP1 hyperactivation underwent surprisingly rapid and highly reproducible tumorigenesis, developing tongue carcinoma in situ within 2 weeks and invasive SC...
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#1Hyo Ju Park (UNIST: Ulsan National Institute of Science and Technology)H-Index: 10
#2Janghwan Cha (Sejong University)H-Index: 4
Last. Zonghoon Lee (UNIST: Ulsan National Institute of Science and Technology)H-Index: 34
view all 9 authors...
Hexagonal boron nitride (hBN) is an insulating two-dimensional (2D) material with a large bandgap. Although known for its interfacing with other 2D materials and structural similarities to graphene, the potential use of hBN in 2D electronics is limited by its insulating nature. Here, we report atomically sharp twin boundaries at AA′/AB stacking boundaries in chemical vapor deposition–synthesized few-layer hBN. We find that the twin boundary is composed of a 6′6′ configuration, showing conducting...
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#1Bugra Ayan (PSU: Pennsylvania State University)H-Index: 5
#2Dong Nyoung Heo (Kyung Hee University)H-Index: 18
Last. Ibrahim T. OzbolatH-Index: 25
view all 7 authors...
Three-dimensional (3D) bioprinting is an appealing approach for building tissues; however, bioprinting of mini-tissue blocks (i.e., spheroids) with precise control on their positioning in 3D space has been a major obstacle. Here, we unveil “aspiration-assisted bioprinting (AAB),” which enables picking and bioprinting biologics in 3D through harnessing the power of aspiration forces, and when coupled with microvalve bioprinting, it facilitated different biofabrication schemes including scaffold-b...
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#1E. Dalaka (St And: University of St Andrews)
#2Nils M. Kronenberg (St And: University of St Andrews)H-Index: 14
Last. Malte C. Gather (St And: University of St Andrews)H-Index: 34
view all 6 authors...
Mechanobiology plays a prominent role in cancer invasion and metastasis. The ability of a cancer to degrade extracellular matrix (ECM) is likely connected to its invasiveness. Many cancer cells form invadopodia—micrometer-sized cellular protrusions that promote invasion through matrix degradation (proteolysis). Although it has been hypothesized that invadopodia exert mechanical force that is implicated in cancer invasion, direct measurements remain elusive. Here, we use a recently developed inte...
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#1Sabrina Weickert (University of Konstanz)H-Index: 2
#2Magdalena Wawrzyniuk (UU: Utrecht University)
Last. Malte Drescher (University of Konstanz)H-Index: 23
view all 5 authors...
Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer’s disease with Tau oligomers suspected as the most toxic agent. Tau is a client of the molecular chaperone Hsp90, although it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, although “paper clip...
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#1Qianqian Ni (NU: Nanjing University)H-Index: 8
#2Fuwu Zhang (NIH: National Institutes of Health)H-Index: 23
Last. Guangming Lu (NU: Nanjing University)H-Index: 46
view all 12 authors...
Neoantigen vaccines have been enthusiastically pursued for personalized cancer immunotherapy while vast majority of neoantigens have no or low immunogenicity. Here, a bi-adjuvant neoantigen nanovaccine (banNV) that codelivered a peptide neoantigen (Adpgk) with two adjuvants [Toll-like receptor (TLR) 7/8 agonist R848 and TLR9 agonist CpG] was developed for potent cancer immunotherapy. Specifically, banNVs were prepared by a nanotemplated synthesis of concatemer CpG, nanocondensation with cationic...
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#1Meike Kespohl (Humboldt University of Berlin)H-Index: 1
#2Clara Bredow (Humboldt University of Berlin)H-Index: 1
Last. Henry Fechner (Technical University of Berlin)H-Index: 11
view all 19 authors...
Protein modification with ISG15 (ISGylation) represents a major type I IFN–induced antimicrobial system. Common mechanisms of action and species-specific aspects of ISGylation, however, are still ill defined and controversial. We used a multiphasic coxsackievirus B3 (CV) infection model with a first wave resulting in hepatic injury of the liver, followed by a second wave culminating in cardiac damage. This study shows that ISGylation sets nonhematopoietic cells into a resistant state, being indi...
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