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Sabrina Weickert
University of Konstanz
ChemistryElectron paramagnetic resonanceRedoxPhotochemistryLigand
8Publications
2H-index
21Citations
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Publications 11
Newest
#1Philipp RohseH-Index: 1
#2Sabrina WeickertH-Index: 2
Last. Valentin WittmannH-Index: 27
view all 4 authors...
Multivalent ligand-protein interactions are a key concept in biology mediating, for example, signalling and adhesion. Multivalent ligands often have tremendously increased binding affinities. However, they also can cause crosslinking of receptor molecules leading to precipitation of ligand-receptor complexes. Plaque formation due to precipitation is a known characteristic of numerous fatal diseases limiting a potential medical application of multivalent ligands with a precipitating binding mode....
1 CitationsSource
#1Sabrina Weickert (University of Konstanz)H-Index: 2
#2Magdalena Wawrzyniuk (UU: Utrecht University)
Last. Malte Drescher (University of Konstanz)H-Index: 23
view all 5 authors...
Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer’s disease with Tau oligomers suspected as the most toxic agent. Tau is a client of the molecular chaperone Hsp90, although it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, although “paper clip...
Source
#1Andreas Scherer (University of Konstanz)
#2Sonja Tischlik (University of Konstanz)
Last. Malte Drescher (University of Konstanz)H-Index: 23
view all 5 authors...
Abstract. EPR distance determination in the nanometre region has become an important tool for studying the structure and interaction of macromolecules. Arbitrary waveform generators (AWGs), which have recently become commercially available for EPR spectrometers, have the potential to increase the sensitivity of the most common technique double electron-electron resonance (DEER, also called PELDOR), as they allow the generation of broadband pulses. There are several families of broadband pulses, ...
Source
#1Sabrina Weickert (University of Konstanz)H-Index: 2
#2Magdalena Wawrzyniuk (UU: Utrecht University)
Last. Malte Drescher (University of Konstanz)H-Index: 23
view all 5 authors...
Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimers disease with Tau oligomers suspected as the most toxic agent. Tau is a client of Hsp90, though it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, though paper-clip-shaped by long-range contacts...
Source
#1Sabrina WeickertH-Index: 2
#2Julia CattaniH-Index: 2
Last. Malte DrescherH-Index: 23
view all 3 authors...
Intrinsically disordered proteins (IDPs) play important physiological, but also disease-related roles. In order to understand the function and malfunction of proteins of this class, electron paramagnetic resonance (EPR) spectroscopy has proven to be a valuable tool, allowing investigation of the protein structural ensembles upon interaction with the environment. This review focuses on the IDPs tau and α-synuclein and gives an overview over recent EPR studies performed with these proteins.
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#1Sabrina Weickert (University of Konstanz)H-Index: 2
#2Torben Seitz (University of Konstanz)H-Index: 1
Last. Valentin Wittmann (University of Konstanz)H-Index: 27
view all 6 authors...
Multivalent carbohydrate–lectin interactions are a key concept in biological processes mediating, for example, signaling and adhesion. Binding affinities of multivalent ligands often increase by orders of magnitude compared to a monovalent binding situation. Thus, the design of multivalent ligands as potent inhibitors is a highly active field of research, where knowledge about the binding site topology is crucial. Here, we report a general strategy for precise distance measurements between the b...
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#1Katharina Susanne Bücher (HHU: University of Düsseldorf)H-Index: 3
#2Hao Yan (Heinrich Pette Institute)H-Index: 2
Last. Laura Hartmann (HHU: University of Düsseldorf)H-Index: 24
view all 16 authors...
Norovirus infection is the major cause of nonbacterial gastroenteritis in humans and has been the subject of numerous studies investigating the virus’s biophysical properties and biochemical function with the aim of deriving novel and highly potent entry inhibitors to prevent infection. Recently, it has been shown that the protruding P domain dimer (P-dimer) of a GII.10 Norovirus strain exhibits two new binding sites for l-fucose in addition to the canonical binding sites. Thus, these sites prov...
8 CitationsSource
A series of mononuclear σ-phenyl ruthenium complexes Ru(CO)Cl(C6H4-R)(PiPr3)2 (R = OMe, CH3, H, F, CF3) were synthesized and analyzed with respect to their electrochemical and spectroscopic properties. To these ends, cyclic voltammetry, IR, and UV/Vis/NIR spectroelectrochemistry as well as EPR spectroscopy on their one-electron oxidized radical cations were employed. Experimental work is complimented by quantum chemical calculations. Our studies reveal that the σ-phenyl ligand strongly contribut...
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#1Sabrina Weickert (University of Konstanz)H-Index: 2
#2Malte Drescher (University of Konstanz)H-Index: 23
This chapter summarizes the state of the art in electron paramagnetic resonance (EPR) spectroscopy. It should give the reader an overview of the tremendous methodological developments and applications, which have a huge impact on the fields of biophysics, biology, biochemistry, material sciences, solid state physics, and physical organic chemistry. The basic theory and principles of continuous wave (CW) EPR are introduced, as well as principles and common experiments of pulse EPR. We discuss, ho...
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#1Stefan ScheererH-Index: 5
#2Michael LinseisH-Index: 11
Last. Rainer F. WinterH-Index: 6
view all 10 authors...
Metallamacrocylic tetraruthenium complexes were generated by treatment of 1,4-divinylphenylene-bridged diruthenium complexes with functionalized 1,3-benzene dicarboxylic acids and characterized by HR ESI-MS and multinuclear NMR spectroscopy. Every divinylphenylene diruthenium subunit is oxidized in two consecutive one-electron steps with half-wave potential splittings in the range of 250 to 330 mV. Additional, smaller redox-splittings between the +/2+ and 0/+ and the 3+/4+ and 2+/3+ redox proces...
13 CitationsSource
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