Original paper
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
Abstract
Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene...
Figures & Tables
Fig. 1 Intermittent fasting alleviated insulin resistance and cognitive impairme...
Fig. 2 Intermittent fasting improved synapse ultrastructure and altered IRS/Akt ...
Fig. 4 Gut microbiome and plasma metabolome analysis of intermittent fasting-tre...
Fig. 6 The effects of antibiotics and microbial metabolites on the cognitive fun...
Paper Details
Title
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
Published Date
Feb 18, 2020
Journal
Volume
11
Issue
1
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