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#1Blair Armistead (Seattle Children's Research Institute)H-Index: 5
#2Pilar Herrero-Foncubierta (UGR: University of Granada)H-Index: 1
Last. Ali Haidour (UGR: University of Granada)H-Index: 20
view all 17 authors...
Although certain microbial lipids are toxins, the structural features important for cytotoxicity remain unknown. Increased functional understanding is essential for developing therapeutics against toxic microbial lipids. Group B Streptococci (GBS) are bacteria associated with preterm births, stillbirths, and severe infections in neonates and adults. GBS produce a pigmented, cytotoxic lipid, known as granadaene. Despite its importance to all manifestations of GBS disease, studies towards understa...
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#1Ying Xu (CAS: Chinese Academy of Sciences)H-Index: 5
#2Zhe Zhao (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Yuhui Wang (NKU: Nankai University)
view all 13 authors...
The ability to grow at moderate acidic conditions (pH 4.0–5.0) is important to Escherichia coli colonization of the host’s intestine. Several regulatory systems are known to control acid resistance in E. coli, enabling the bacteria to survive under acidic conditions without growth. Here, we characterize an acid-tolerance response (ATR) system and its regulatory circuit, required for E. coli exponential growth at pH 4.2. A two-component system CpxRA directly senses acidification through protonati...
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#1Christina A. von Roemeling (UF: University of Florida)H-Index: 12
#2Yifan Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
Last. Katelyn A. Bruno (Mayo Clinic)H-Index: 2
view all 18 authors...
Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47. Here, we show that CD47 blockade alone is inefficient in stimulating glioma cell phagocytosis. However, combining CD47 blockade with temozolomide results in a significant pro-phagocytosis effect due to the latter’s ability to induce endoplasmic reticulum stress response. Increased tumour cel...
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#1Zhongqiang Wang (Northeast Normal University)H-Index: 13
#2Tao Zeng (Northeast Normal University)H-Index: 1
Last. Daniele Ielmini (Polytechnic University of Milan)H-Index: 56
view all 8 authors...
The close replication of synaptic functions is an important objective for achieving a highly realistic memristor-based cognitive computation. The emulation of neurobiological learning rules may allow the development of neuromorphic systems that continuously learn without supervision. In this work, the Bienenstock-Cooper-Munro learning rule, as a typical case of spike-rate-dependent plasticity, is mimicked using a generalized triplet-spike-timing-dependent plasticity scheme in a WO3−x memristive ...
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#1Gyung-Min Choi (SKKU: Sungkyunkwan University)H-Index: 9
#2Jung Hyun Oh (KU: Korea University)H-Index: 1
Last. Hyun Woo Lee (POSTECH: Pohang University of Science and Technology)H-Index: 73
view all 9 authors...
Spin current generation through the spin-orbit interaction in non-magnetic materials lies at the heart of spintronics. When the generated spin current is injected to a ferromagnet, it produces spin-orbit torque and manipulates magnetization efficiently. Optically generated spin currents are expected to be superior to their electrical counterparts in terms of the manipulation speed. Here we report optical spin-orbit torques in heavy metal/ferromagnet heterostructures. The strong spin-orbit coupli...
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#1Ying Zhang (University of Freiburg)H-Index: 8
#2Genís Valentín Gesé (Heidelberg University)H-Index: 2
Last. Irmgard Sinning (Heidelberg University)H-Index: 37
view all 8 authors...
The conserved ribosome-associated complex (RAC) consisting of Zuo1 (Hsp40) and Ssz1 (non-canonical Hsp70) acts together with the ribosome-bound Hsp70 chaperone Ssb in de novo protein folding at the ribosomal tunnel exit. Current models suggest that the function of Ssz1 is confined to the support of Zuo1, however, it is not known whether RAC by itself serves as a chaperone for nascent chains. Here we show that, via its rudimentary substrate binding domain (SBD), Ssz1 directly binds to emerging na...
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#1Rebecca Louise Miller (University of Oxford)
#2Scott E. Guimond (Keele University)H-Index: 24
Last. Márkó Grabarics (FU: Free University of Berlin)
view all 16 authors...
Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date. Here, we develop a “Shotgun” Ion Mobility Mass Spectrometry Sequencing (SIMMS2) method in which intact HS saccharides are dissociated in an ion mobility mass spectrometer and collision cross section values of fragments measured. Matching of data for intact...
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#1Dirk V. Erler (SCU: Southern Cross University)H-Index: 19
#2Hanieh Tohidi Farid (SCU: Southern Cross University)
Last. Janice M. Lough (Australian Institute of Marine Science)H-Index: 56
view all 5 authors...
Anthropogenic nutrient discharge to coastal marine environments is commonly associated with excessive algal growth and ecosystem degradation. However in the world’s largest coral reef ecosystem, the Great Barrier Reef (GBR), the response to enhanced terrestrial nutrient inputs since European settlement in the 1850’s remains unclear. Here we use a 333 year old composite record (1680–2012) of 15N/14N in coral skeleton-bound organic matter to understand how nitrogen cycling in the coastal GBR has r...
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#1Dapeng Sun (University of Pittsburgh)
#2Natalia V. Varlakhanova (University of Pittsburgh)H-Index: 2
Last. Marijn G. J. Ford (University of Pittsburgh)H-Index: 10
view all 6 authors...
Sorting nexins (SNX) are a family of PX domain-containing proteins with pivotal roles in trafficking and signaling. SNX-BARs, which also have a curvature-generating Bin/Amphiphysin/Rvs (BAR) domain, have membrane-remodeling functions, particularly at the endosome. The minimal PX-BAR module is a dimer mediated by BAR-BAR interactions. Many SNX-BAR proteins, however, additionally have low-complexity N-terminal regions of unknown function. Here, we present the cryo-EM structure of the full-length S...
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#1Gabrielle A. Josling (PSU: Pennsylvania State University)H-Index: 8
#2Timothy J Russell (PSU: Pennsylvania State University)H-Index: 1
Last. Manuel Llinás (PSU: Pennsylvania State University)H-Index: 40
view all 7 authors...
In the malaria parasite Plasmodium falciparum, the switch from asexual multiplication to sexual differentiation into gametocytes is essential for transmission to mosquitos. The transcription factor PfAP2-G is a key determinant of sexual commitment that orchestrates this crucial cell fate decision. Here we identify the direct targets of PfAP2-G and demonstrate that it dynamically binds hundreds of sites across the genome. We find that PfAP2-G is a transcriptional activator of early gametocyte gen...
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