Match!
Nature Communications
IF
11.88
Papers
25207
Papers 27708
1 page of 2,771 pages (27.7k results)
Newest
#1Valérie Guillet (University of Toulouse)H-Index: 3
#2Patricia Bordes (University of Toulouse)H-Index: 3
Last.I. Mares-Mejia (University of Toulouse)
view all 13 authors...
SecB chaperones assist protein export by binding both unfolded proteins and the SecA motor. Certain SecB homologs can also control toxin-antitoxin (TA) systems known to modulate bacterial growth in response to stress. In such TA-chaperone (TAC) systems, SecB assists the folding and prevents degradation of the antitoxin, thus facilitating toxin inhibition. Chaperone dependency is conferred by a C-terminal extension in the antitoxin known as chaperone addiction (ChAD) sequence, which makes the ant...
#1Bohdan Senyuk (CU: University of Colorado Boulder)H-Index: 21
#2Jure Aplinc (University of Ljubljana)H-Index: 2
Last.Ivan I. Smalyukh (CU: University of Colorado Boulder)H-Index: 36
view all 4 authors...
Achieving and exceeding diversity of colloidal analogs of chemical elements and molecules as building blocks of matter has been the central goal and challenge of colloidal science ever since Einstein introduced the colloidal atom paradigm. Recent advances in colloids assembly have been achieved by exploiting the machinery of DNA hybridization but robust physical means of defining colloidal elements remain limited. Here we introduce physical design principles allowing us to define high-order elas...
#1Rémy Pawlak (University of Basel)H-Index: 17
#2J. G. Vilhena (University of Basel)
Last.Ernst Meyer (University of Basel)H-Index: 57
view all 9 authors...
Cryo-electron microscopy can determine the structure of biological matter in vitrified liquids. However, structure alone is insufficient to understand the function of native and engineered biomolecules. So far, their mechanical properties have mainly been probed at room temperature using tens of pico-newton forces with a resolution limited by thermal fluctuations. Here we combine force spectroscopy and computer simulations in cryogenic conditions to quantify adhesion and intra-molecular properti...
#1Yuan Ge (UBC: University of British Columbia)H-Index: 9
#2Meng Tian (UBC: University of British Columbia)
Last.Jie Lu (UBC: University of British Columbia)H-Index: 11
view all 11 authors...
The α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptors (AMPARs) mediate the fast excitatory synaptic transmission in the mammalian brain and are important for synaptic plasticity. In particular, the rapid insertion of the GluA1 homomeric (GluA1-homo) AMPARs into the postsynaptic membrane is considered to be critical in the expression of hippocampal CA1 long-term potentiation (LTP), which is important for certain forms of learning and memory. However, how the formati...
#1Alexander T. Baker (Cardiff University)H-Index: 2
#2Alexander Greenshields-Watson (Cardiff University)H-Index: 1
Last.Alan L. Parker (Cardiff University)H-Index: 22
view all 8 authors...
Adenovirus based vectors are of increasing importance for wide ranging therapeutic applications. As vaccines, vectors derived from human adenovirus species D serotypes 26 and 48 (HAdV-D26/48) are demonstrating promising efficacy as protective platforms against infectious diseases. Significant clinical progress has been made, yet definitive studies underpinning mechanisms of entry, infection, and receptor usage are currently lacking. Here, we perform structural and biological analysis of the rece...
#1Weiduo Zhu (NU: University of Nebraska–Lincoln)H-Index: 2
#2Weiduo Zhu (NU: University of Nebraska–Lincoln)
Last.Joseph S. Francisco (NU: University of Nebraska–Lincoln)H-Index: 11
view all 11 authors...
Water can freeze into diverse ice polymorphs depending on the external conditions such as temperature (T) and pressure (P). Herein, molecular dynamics simulations show evidence of a high-density orthorhombic phase, termed ice χ, forming spontaneously from liquid water at room temperature under high-pressure and high external electric field. Using free-energy computations based on the Einstein molecule approach, we show that ice χ is an additional phase introduced to the state-of-the-art T–P phas...
#1Gerburg K. Schwaerzer (UCSD: University of California, San Diego)H-Index: 2
#2Hema Kalyanaraman (UCSD: University of California, San Diego)H-Index: 5
Last.Hemal H. Patel (UCSD: University of California, San Diego)H-Index: 41
view all 0 authors...
People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults. Here we report that mice heterozygous for the mutation have a three-fold increase in basal protein kinase G (PKG) activity, and develop age-dependent aortic dilation. Prkg1R177Q/+ aortas show increased smooth muscle cell apoptosis, elastin fiber breaks, and oxidative stress compared to aortas from wild type littermates. Transverse aort...
#1Shaobo Xi (CAS: Chinese Academy of Sciences)
#2Guoming Lin (CAS: Chinese Academy of Sciences)
Last.Kui Xie (CAS: Chinese Academy of Sciences)H-Index: 26
view all 0 authors...
Pseudocapacitors that originate from chemisorption contain redox active sites mainly composed of transition metal ions with unsaturated coordination in lattice on the electrode surface. The capacitance is generally dictated by the synergy of the porous microstructure, electronic conduction and active sites in the porous electrode. Here we grow metallic porous nitride single crystals at 2-cm scale to enhance pseudocapacitance through the combination of large surface area with porous microstructur...
#1Sophie E. Holmes (Yale University)H-Index: 6
#2Dustin Scheinost (Yale University)H-Index: 26
Last.Robert H. Pietrzak (Yale University)H-Index: 48
view all 15 authors...
Synaptic loss and deficits in functional connectivity are hypothesized to contribute to symptoms associated with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). The synaptic vesicle glycoprotein 2A (SV2A) can be used to index the number of nerve terminals, an indirect estimate of synaptic density. Here, we used positron emission tomography (PET) with the SV2A radioligand [11C]UCB-J to examine synaptic density in n = 26 unmedicated individuals with MDD, PTSD, or comorbi...
#1Koki Muraoka (UTokyo: University of Tokyo)H-Index: 5
#2Yuki Sada (UTokyo: University of Tokyo)
Last.Tatsuya Okubo (UTokyo: University of Tokyo)H-Index: 41
view all 0 authors...
Correlating synthesis conditions and their consequences is a significant challenge, particularly for materials formed as metastable phases via kinetically controlled pathways, such as zeolites, owing to a lack of descriptors that effectively illustrate the synthesis protocols and their corresponding results. This study analyzes the synthetic records of zeolites compiled from the literature using machine learning techniques to rationalize physicochemical, structural, and heuristic insights to the...
12345678910