Match!

Dietary Intervention with Oatmeal in Patients with uncontrolled Type 2 Diabetes Mellitus – A Crossover Study

Published on Oct 1, 2019in Experimental and Clinical Endocrinology & Diabetes1.927
· DOI :10.1055/a-0677-6068
Graciela Delgado20
Estimated H-index: 20
(Heidelberg University),
Marcus E. Kleber51
Estimated H-index: 51
(Heidelberg University)
+ 9 AuthorsAlexander Lammert10
Estimated H-index: 10
(Heidelberg University)
Abstract
Background In a pilot study, we evaluated the efficacy of two days of oatmeal on insulin resistance and glucose metabolism and found a marked decrease of insulin requirements. The most important shortcoming of that study was that the interventions were not isocaloric (diabetes adapted diet: 1500 kcal/d vs. oatmeal 1100 kcal/d). To address these drawbacks we designed the OatMeal And Insulin Resistance (OMA-IR) study. Methods The study was a randomized, open label crossover dietary intervention study with consecutive inclusion of 15 patients with uncontrolled type 2 diabetes. The intervention comprised two days of oatmeal on days 3 and 4 of a 5 days hospital stay. During the control period, patients received a diabetes mellitus adapted diet only. The primary endpoint was the daily insulin requirement and glycemic control. Results Upon oatmeal treatment, the required insulin dose could be significantly reduced on the third and fourth day as compared to the second day of inpatient stay (82.0±30.3 and 69.9±29.9IU versus 112±36.2IU;P Conclusion In this crossover study, two days of oatmeal intervention allowed a highly significant reduction of required daily insulin doses while maintaining adequate metabolic control as compared to a diabetes adapted diet only. The beneficial effects of the intervention might last for several weeks as shown by the lower HbA1c four weeks after the intervention.
  • References (15)
  • Citations (2)
📖 Papers frequently viewed together
201915.27Diabetes Care
13 Authors (Daniela Jakubowicz, ..., Oren Froy)
3 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References15
Newest
#1Roghayeh Zare (Shiraz University of Medical Sciences)H-Index: 2
#2Azadeh NadjarzadehH-Index: 8
Last. Mojtaba Heydari (Shiraz University of Medical Sciences)H-Index: 12
view all 5 authors...
Summary Background & aims Multiple studies have evaluated the hypoglycemic effect of cinnamon in patients with diabetes mellitus (DM) type II, with conflicting results. Differences in Baseline Body Mass Index (BMI) of patients may be able to explain the observed differences in the results. This study was designed to evaluate the effect of cinnamon supplementation on anthropometric, glycemic and lipid outcomes of patients with DM type II based on their baseline BMI. Methods The study was designed...
13 CitationsSource
Last. Robert E. Steinert (DSM)H-Index: 21
view all 7 authors...
Reducing the glycaemic response to carbohydrate-containing foods may have desirable physiological effects for many people. Here, we aimed to determine the minimum amount of oat β-glucan from oat-bran which, when added to instant-oatmeal, would reduce the glycaemic response by 20% compared to a β-glucan-free cereal. Therefore, the glycaemic responses elicited by one serving (27 g) instant-oatmeal plus 247 g 2% milk (IO, 28 g available-carbohydrate, 1.2 g β-glucan) or IO plus 0.2, 0.4, 0.8 or 1.6 ...
2 CitationsSource
#1Liping Zhao (RU: Rutgers University)H-Index: 40
#2Feng Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last. Chenhong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 33 authors...
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients w...
201 CitationsSource
#1Michael E. J. Lean (Glas.: University of Glasgow)H-Index: 79
#2W. S. Leslie (Glas.: University of Glasgow)H-Index: 16
Last. Roy Taylor (Newcastle University)H-Index: 47
view all 25 authors...
Summary Background Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight management within routine primary care would achieve remission of type 2 diabetes. Methods We did this open-label, cluster-randomised trial (DiRECT) at 49 primary care practices in Scotland and the Tyneside region of England. Practices were randomly assigned (1:1), via a computer-generated list, to provide either a weight management programme (intervention) or be...
207 CitationsSource
#1Qingtao HouH-Index: 2
#2Yun LiH-Index: 4
Last. Haoming TianH-Index: 22
view all 7 authors...
The present study aimed to comprehensively assess if oats intake is beneficial for diabetic patients. The literature search was conducted in PubMed database up to 23 August 2015. Fourteen controlled trials and two uncontrolled observational studies were included. Compared with the controls, oats intake significantly reduced the concentrations of glycosylated hemoglobin A1c (HbA1c) (MD, −0.42%; 95% CI, −0.61% to −0.23%), fasting blood glucose (FBG) (MD, −0.39 mmol/L; 95% CI, −0.58 to −0.19 mmol/L...
27 CitationsSource
#1Roland ZermH-Index: 8
#2Matthias KrözH-Index: 13
Die Behandlung von Typ-2-Diabetikern mit ausgepragter Insulinresistenz ist eine Herausforderung, da eine Erhohung der Insulindosis haufig ohne Wirkung auf die Blutzuckerwerte bleibt. Eine Hyperinsulinamie ist mit Gewichtszunahme, erhohtem kardiovaskularem und kanzerogenem Risiko assoziiert. Zwei sogenannte Hafertage konnen die Insulinresistenz verbessern. Die Wirkmechanismen sind bisher nicht bekannt, allerdings konnte ein positiver Einfluss auf die Darmflora eine Rolle spielen.
1 CitationsSource
126k Citations
#1Susan M. Tosh (AAFC: Agriculture and Agri-Food Canada)H-Index: 28
Review of human studies investigating the post-prandial blood-glucose lowering ability of oat and barley food products
115 CitationsSource
The crossover design has a long history in the planning of scientific trials ([1], sect. 1.4) and forms the basis of a large number of clinical studies year after year. Trials in almost all clinical disciplines use the crossover design, but it accounts for a particularly high proportion of studies in the “CNS specialties”—neurology and psychiatry—and of trials on pain treatment. One example of the latter is the frequently cited study of the analgesic effect of synthetic cannabinoids (2). This wa...
173 CitationsSource
#1Allan Mazur (SU: Syracuse University)H-Index: 34
In the decade before the discovery of insulin, the prominent American physicians Frederick Allen and Elliott Joslin advocated severe fasting and undernutrition to prolong the lives of diabetic patients. Detractors called this "starvation dieting," and some patients did indeed starve to death. Allen and Joslin promoted the therapy as a desperate application of animal experimentation to clinical treatment, and texts still describe it that way. This justification was exaggerated. The public record ...
15 CitationsSource
Cited By2
Newest
Abstract Objectives To report on the potential effectiveness of hypocaloric, plant-based short-term dietary oatmeal interventions in the treatment of insulin resistance in critically ill patients on the intensive care unit. Clinical features and outcome A 67-year-old female with type 2 diabetes was admitted to our hospital with suspected pneumonia. The patient developed acute hypoxemic respiratory failure and was diagnosed with pneumogenic sepsis requiring invasive ventilation and an immediate t...
Source
Abstract Dietary modifications play a central role in the treatment of diabetes. Educating and empowering individuals to make better dietary choices is a challenging task. In this context, one potential dietetic approach to achieve better glycemic control in type 2 diabetes is often overlooked: the use of short-term dietary oatmeal interventions. This concept has been described more than a hundred years ago by the German diabetologist Carl von Noorden. It is still applied in several German hospi...
Source
Background:Lifestyle interventions, including dietary modifications, play a key role in the treatment of type 2 diabetes. By the second half of the last century, dietary oatmeal interventions had f...
Source