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Marcus E. Kleber
Heidelberg University
299Publications
47H-index
13.9kCitations
Publications 299
Newest
Published on Feb 26, 2019in Scientific Reports 4.12
Boris Schmitz9
Estimated H-index: 9
,
Marcus E. Kleber47
Estimated H-index: 47
(University of Jena)
+ 8 AuthorsWinfried März87
Estimated H-index: 87
(Medical University of Graz)
Chronic kidney disease (CKD) is an independent risk factor for onset and progression of coronary artery disease (CAD). Discovery of predisposing loci for kidney function in CAD patients was performed using a genome-wide association approach. Inclusion criteria were CAD with ≥50% stenosis (≥1 coronary artery) and a creatinine-based estimated glomerular filtration rate (eGFR) of 30–75 ml/min/1.73 m2. An association of rs139401390 located to a region 58.8 kb upstream of renalase (RNLS) with eGFR wa...
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Published on Jan 31, 2019in Scientific Reports 4.12
Tanja B. Grammer30
Estimated H-index: 30
(Heidelberg University),
Alexander Dressel6
Estimated H-index: 6
(Heidelberg University)
+ 10 AuthorsDavid Pittrow35
Estimated H-index: 35
(Dresden University of Technology)
Guidelines for prevention of cardiovascular diseases use risk scores to guide the intensity of treatment. A comparison of these scores in a German population has not been performed. We have evaluated the correlation, discrimination and calibration of ten commonly used risk equations in primary care in 4044 participants of the DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) study. The risk equations correlate well with each other. All r...
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Published on Jan 24, 2019in Scientific Reports 4.12
Claudia Sommerer30
Estimated H-index: 30
(Heidelberg University),
Matthias Zeiler53
Estimated H-index: 53
(Heidelberg University)
+ 6 AuthorsMarcus E. Kleber47
Estimated H-index: 47
(Heidelberg University)
Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovascular Health study over a very long follow-up time of nearly 10 years. We estimated overall risk of all-cause and cardiovascular death by Cox proportional hazards regression according to quartiles of ...
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Published on Jun 1, 2019in Endocrine connections 3.04
Vito Francic , Martin Keppel1
Estimated H-index: 1
+ 13 AuthorsGraciela Delgado21
Estimated H-index: 21
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Published on May 25, 2019in European Journal of Nutrition 4.42
Irene Pusceddu4
Estimated H-index: 4
,
Wolfgang A. Herrmann94
Estimated H-index: 94
+ 5 AuthorsMarkus Herrmann32
Estimated H-index: 32
(Medical University of Graz)
Purpose Short telomeres and B vitamin deficiencies have been proposed as risk factors for age-related diseases and mortality that interact through oxidative stress and inflammation. However, available data to support this concept are insufficient. We aimed to investigate the predictive role of B vitamins and homocysteine (HCY) for mortality in cardiovascular patients. We explored potential relationships between HCY, B vitamins, relative telomere length (RTL), and indices of inflammation.
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Published on May 10, 2019in PLOS ONE 2.77
Cavin K. Ward-Caviness10
Estimated H-index: 10
,
Paul S. de Vries14
Estimated H-index: 14
+ 55 AuthorsTim Kacprowski16
Estimated H-index: 16
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Published on Apr 1, 2019
Riyaz Patel9
Estimated H-index: 9
(University College London),
Vinicius Tragante17
Estimated H-index: 17
+ 178 AuthorsSalim S. Virani35
Estimated H-index: 35
(Michael E. DeBakey Veterans Affairs Medical Center in Houston)
Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study p...
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Published on Apr 1, 2019
Riyaz Patel9
Estimated H-index: 9
(St Bartholomew's Hospital),
Amand F. Schmidt9
Estimated H-index: 9
+ 164 AuthorsSalim S. Virani35
Estimated H-index: 35
(Baylor College of Medicine)
Background: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. Methods: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Co...
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