Marcus E. Kleber
Heidelberg University
Publications 285
Published on Jan 2, 2019in Nutrients 4.20
Thor Aspelund65
Estimated H-index: 65
Martin R. Grübler14
Estimated H-index: 14
+ 30 AuthorsRagnar Martin Joakimsen32
Estimated H-index: 32
The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D Standardization Program. Most relevant single nucleotide polymorphisms of the genes CYP2R1 (rs12794714,...
2 Citations Source Cite
Published on Jan 23, 2019in bioRxiv
Lingyao Zeng (Ludwig Maximilian University of Munich), Nazanin Mirza-Schreiber3
Estimated H-index: 3
(Max Planck Society)
+ 29 AuthorsBeibei Jiang (Max Planck Society)
Identification of epistasis affecting complex human traits has been challenging. Focusing on known coronary artery disease (CAD) risk loci, we explore pairwise statistical interactions between 8,068 SNPs from ten CAD genome-wide association studies (n=30,180). We discovered rs1800769 and rs9458001 in the vicinity of the LPA locus to interact in modulating CAD risk (P=1.75e-13). Specific genotypes (e.g., rs1800769 CT) displayed either significantly decreased or increased risk for CAD in the conte...
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Published on Jan 31, 2019in Scientific Reports 4.12
Tanja B. Grammer29
Estimated H-index: 29
(Heidelberg University),
Alexander Dressel6
Estimated H-index: 6
(Heidelberg University)
+ 10 AuthorsDavid Pittrow35
Estimated H-index: 35
(Dresden University of Technology)
Guidelines for prevention of cardiovascular diseases use risk scores to guide the intensity of treatment. A comparison of these scores in a German population has not been performed. We have evaluated the correlation, discrimination and calibration of ten commonly used risk equations in primary care in 4044 participants of the DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) study. The risk equations correlate well with each other. All r...
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Published on Jan 1, 2019in European Journal of Epidemiology 7.02
Toni Meier13
Estimated H-index: 13
(Martin Luther University of Halle-Wittenberg),
Kira Gräfe1
Estimated H-index: 1
(Martin Luther University of Halle-Wittenberg)
+ 6 AuthorsStefan Lorkowski21
Estimated H-index: 21
(University of Jena)
This study was performed to highlight the relationship between single dietary risk factors and cardiovascular diseases (CVDs) in the WHO European Region. We used the comparative risk assessment framework of the Global Burden of Disease Study to estimate CVD mortality attributable to diet; comprising eleven forms of CVDs, twelve food and nutrient groups and 27 risk-outcome pairs in four GBD regions including 51 countries by age and sex between 1990 and 2016. In 2016, dietary risks were associated...
3 Citations Source Cite
Published on Jan 24, 2019in Scientific Reports 4.12
Claudia Sommerer29
Estimated H-index: 29
(Heidelberg University),
Matthias Zeiler51
Estimated H-index: 51
(Heidelberg University)
+ 6 AuthorsMarcus E. Kleber45
Estimated H-index: 45
(Heidelberg University)
Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovascular Health study over a very long follow-up time of nearly 10 years. We estimated overall risk of all-cause and cardiovascular death by Cox proportional hazards regression according to quartiles of ...
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Published on Jan 1, 2019in Journal of Clinical Lipidology 3.58
Daniel Wadsack1
Estimated H-index: 1
Horst Sattler1
Estimated H-index: 1
+ 5 AuthorsTanja B. Grammer29
Estimated H-index: 29
(Heidelberg University)
Abstract A 33-year-old female had suffered from spontaneously recurrent bursitis and tendosynovitis/enthesitis of the patellar and Achilles tendons for about 10 years. The episodes of immobilization increased. Ultrasound imaging of the swollen and painful tendons showed chronic inflammation with neoangiogenesis within the tendons and hypoechoic lesions. Clinical and laboratory tests did not provide evidence for a rheumatic disease. Low density lipoprotein cholesterol was elevated. Biopsies of sk...
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Published on Jan 29, 2019in Circulation 18.88
Maria Sabater-Lleal18
Estimated H-index: 18
(Karolinska University Hospital),
Jennifer E. Huffman40
Estimated H-index: 40
+ 73 AuthorsStella Trompet44
Estimated H-index: 44
(Leiden University Medical Center)
Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. Methods: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hispanic ancestry. All studies performed linear regression analysis using an additive genetic model an...
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Published on Mar 1, 2019in Atherosclerosis 4.47
Günther Silbernagel1
Estimated H-index: 1
Hubert Scharnagl39
Estimated H-index: 39
(Medical University of Graz)
+ 10 AuthorsUlf Landmesser71
Estimated H-index: 71
Abstract Background and aims High concentrations of low density lipoprotein (LDL) triglycerides have been associated with prevalent angiographic coronary artery disease. The present analysis was designed to investigate the association of LDL triglycerides with cardiovascular mortality and to explore possible mechanisms that may link LDL triglycerides to cardiovascular risk. Methods LDL triglycerides were measured in 3140 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) stu...
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Published on Jan 1, 2019in Journal of the American College of Cardiology 16.83
David Adlam12
Estimated H-index: 12
(National Institute for Health Research),
Timothy Mark Olson28
Estimated H-index: 28
(Mayo Clinic)
+ 234 AuthorsKetan Mishra1
Estimated H-index: 1
(Victor Chang Cardiac Research Institute)
Abstract Background Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged women. Observational studies have reported a high prevalence of extracoronary vascular anomalies, especially fibromuscular dysplasia (FMD) and a low prevalence of coincidental cases of atherosclerosis. PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, wit...
2 Citations Source Cite
Published on Feb 28, 2019in Blood 15.13
Paul S. de Vries13
Estimated H-index: 13
(University of Texas Health Science Center at Houston),
Maria Sabater-Lleal18
Estimated H-index: 18
(Karolinska Institutet)
+ 42 AuthorsJohn D. Eicher17
Estimated H-index: 17
(National Institutes of Health)
Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combin...
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