Match!
Marcus E. Kleber
Heidelberg University
315Publications
47H-index
13.9kCitations
Publications 315
Newest
#1Yongjie Yang (BCM: Baylor College of Medicine)H-Index: 8
#2Agatha A. van der Klaauw (University of Cambridge)H-Index: 15
Last.Antentor Othrell Hinton (BCM: Baylor College of Medicine)H-Index: 8
view all 26 authors...
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozy...
#1Tanja B. Grammer (Heidelberg University)H-Index: 30
#2Alexander Dressel (Heidelberg University)H-Index: 6
Last.David Pittrow (TUD: Dresden University of Technology)H-Index: 35
view all 13 authors...
Guidelines for prevention of cardiovascular diseases use risk scores to guide the intensity of treatment. A comparison of these scores in a German population has not been performed. We have evaluated the correlation, discrimination and calibration of ten commonly used risk equations in primary care in 4044 participants of the DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) study. The risk equations correlate well with each other. All r...
#1Boris SchmitzH-Index: 9
#2Marcus E. Kleber (FSU: University of Jena)H-Index: 47
Last.Stefan-Martin BrandH-Index: 11
view all 11 authors...
Chronic kidney disease (CKD) is an independent risk factor for onset and progression of coronary artery disease (CAD). Discovery of predisposing loci for kidney function in CAD patients was performed using a genome-wide association approach. Inclusion criteria were CAD with ≥50% stenosis (≥1 coronary artery) and a creatinine-based estimated glomerular filtration rate (eGFR) of 30–75 ml/min/1.73 m2. An association of rs139401390 located to a region 58.8 kb upstream of renalase (RNLS) with eGFR wa...
#1Claudia Sommerer (Heidelberg University)H-Index: 30
#2Matthias Zeiler (Heidelberg University)H-Index: 53
Last.Marcus E. Kleber (Heidelberg University)H-Index: 47
view all 9 authors...
Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovascular Health study over a very long follow-up time of nearly 10 years. We estimated overall risk of all-cause and cardiovascular death by Cox proportional hazards regression according to quartiles of ...
#1Graciela Delgado (Heidelberg University)H-Index: 21
#2Marcus E. Kleber (Heidelberg University)H-Index: 47
Last.Winfried März (University of Graz)H-Index: 87
view all 12 authors...
Background In a pilot study, we evaluated the efficacy of two days of oatmeal on insulin resistance and glucose metabolism and found a marked decrease of insulin requirements. The most important shortcoming of that study was that the interventions were not isocaloric (diabetes adapted diet: 1500 kcal/d vs. oatmeal 1100 kcal/d). To address these drawbacks we designed the OatMeal And Insulin Resistance (OMA-IR) study. Methods The study was a randomized, open label crossover dietary intervention st...
#1Adrienne Tin (Johns Hopkins University)H-Index: 19
#2Jonathan Marten (Medical Research Council)H-Index: 18
Last.Z Yu (Johns Hopkins University)
view all 0 authors...
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for p...
#1Tao Huang (PKU: Peking University)H-Index: 15
#2Tiange Wang (Tulane University)
Last.Yujie Wang (UNC: University of North Carolina at Chapel Hill)
view all 134 authors...
Importance Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. Design, Setting, and Participants This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleo...
12345678910