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Graciela Delgado
Heidelberg University
94Publications
21H-index
4,141Citations
Publications 94
Newest
Published on Feb 26, 2019in Scientific Reports4.01
Boris Schmitz9
Estimated H-index: 9
,
Marcus E. Kleber47
Estimated H-index: 47
(FSU: University of Jena)
+ 8 AuthorsStefan-Martin Brand11
Estimated H-index: 11
Chronic kidney disease (CKD) is an independent risk factor for onset and progression of coronary artery disease (CAD). Discovery of predisposing loci for kidney function in CAD patients was performed using a genome-wide association approach. Inclusion criteria were CAD with ≥50% stenosis (≥1 coronary artery) and a creatinine-based estimated glomerular filtration rate (eGFR) of 30–75 ml/min/1.73 m2. An association of rs139401390 located to a region 58.8 kb upstream of renalase (RNLS) with eGFR wa...
Published on Jan 24, 2019in Scientific Reports4.01
Claudia Sommerer30
Estimated H-index: 30
(Heidelberg University),
Matthias Zeiler53
Estimated H-index: 53
(Heidelberg University)
+ 6 AuthorsMarcus E. Kleber47
Estimated H-index: 47
(Heidelberg University)
Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovascular Health study over a very long follow-up time of nearly 10 years. We estimated overall risk of all-cause and cardiovascular death by Cox proportional hazards regression according to quartiles of ...
Published in Atherosclerosis4.25
Guenther Silbernagel25
Estimated H-index: 25
,
Hubert Scharnagl6
Estimated H-index: 6
+ -3 AuthorsStephen Zewinger11
Estimated H-index: 11
Published on Jul 10, 2019in bioRxiv
Sonia Shah34
Estimated H-index: 34
(UCL: University College London),
Albert Henry (UCL: University College London)+ 144 AuthorsMark Chaffin10
Estimated H-index: 10
(Broad Institute)
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report the largest GWAS meta-analysis of HF to-date, comprising 47,309 cases and 930,014 controls. We identify 12 independent associations with HF at 11 genomic loci, all of which demonstrate on...
Published on Jun 1, 2019in Endocrine connections2.47
Vito Francic , Martin Keppel1
Estimated H-index: 1
+ 13 AuthorsGraciela Delgado21
Estimated H-index: 21
Published on May 29, 2019in Clinical Research in Cardiology4.91
Angela P Moissl (Heidelberg University), Graciela Delgado21
Estimated H-index: 21
(Heidelberg University)
+ 3 AuthorsTanja B. Grammer30
Estimated H-index: 30
(Heidelberg University)
Background Low individual socioeconomic status (SES) is a known risk factor for morbidity and mortality. A related measure is the area-based SES (abSES), which describes the average SES of a region. The association of measures of abSES with morbidity and mortality is less well studied.
Published on May 10, 2019in PLOS ONE2.78
Cavin K. Ward-Caviness10
Estimated H-index: 10
,
Paul S. de Vries14
Estimated H-index: 14
+ 55 AuthorsTim Kacprowski16
Estimated H-index: 16
textabstractBackground Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not take advantage of recent genome-wide association studies (GWAS) or multi-variant, pleiotropy robust MR methodologies. Methods and findings We evaluated evidence for a causal effect of fibri...
Published on Apr 1, 2019
Riyaz Patel9
Estimated H-index: 9
(UCL: University College London),
Vinicius Tragante17
Estimated H-index: 17
+ 178 AuthorsSalim S. Virani35
Estimated H-index: 35
(Michael E. DeBakey Veterans Affairs Medical Center in Houston)
Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequen...
Published on Apr 1, 2019
Riyaz Patel9
Estimated H-index: 9
(St Bartholomew's Hospital),
Amand F. Schmidt9
Estimated H-index: 9
+ 164 AuthorsSalim S. Virani35
Estimated H-index: 35
(BCM: Baylor College of Medicine)
Background: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising q...
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