Graciela Delgado
Heidelberg University
Publications 106
#1M Berger (RWTH Aachen University)H-Index: 2
#2Marcus E. Kleber (Heidelberg University)H-Index: 51
Last.Katharina Schuett (RWTH Aachen University)H-Index: 3
view all 8 authors...
#1Sonia Shah (UCL: University College London)H-Index: 36
#2Albert Henry (UCL: University College London)H-Index: 1
Last.R Thomas LumbersH-Index: 3
view all 146 authors...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one o...
#1Graciela Delgado (Heidelberg University)H-Index: 20
#2Bernhard K. Krämer (Heidelberg University)H-Index: 47
Last.Alexander Lammert (Heidelberg University)H-Index: 10
view all 8 authors...
#1Graciela Delgado (Heidelberg University)H-Index: 20
#2Bernhard K. Krämer (Heidelberg University)H-Index: 47
Last.Marcus E. Kleber (Heidelberg University)H-Index: 51
view all 7 authors...
Abstract Background and aims Endothelial dysfunction precedes atherosclerosis and smoking is a well-known risk factor for the development of endothelial dysfunction. The aim of our study was to analyse the effect of smoking on circulating markers of endothelial function and to investigate whether such effects have an influence on the potential use of these markers to estimate cardiovascular risk. Methods Stratified for smoking, levels of sE-/sP-/sL-selectin, von Willebrand (vWF), sICAM-1 and sVC...
#1Robin G Walters (University of Oxford)H-Index: 3
#2David W. Clark (Edin.: University of Edinburgh)H-Index: 6
Last.James F. Wilson (Edin.: University of Edinburgh)H-Index: 107
view all 436 authors...
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32...
1 CitationsSource
#1Boris SchmitzH-Index: 10
#2Marcus E. Kleber (FSU: University of Jena)H-Index: 51
Last.E. BrandH-Index: 31
view all 11 authors...
Chronic kidney disease (CKD) is an independent risk factor for onset and progression of coronary artery disease (CAD). Discovery of predisposing loci for kidney function in CAD patients was performed using a genome-wide association approach. Inclusion criteria were CAD with ≥50% stenosis (≥1 coronary artery) and a creatinine-based estimated glomerular filtration rate (eGFR) of 30–75 ml/min/1.73 m2. An association of rs139401390 located to a region 58.8 kb upstream of renalase (RNLS) with eGFR wa...
#1Claudia Sommerer (Heidelberg University)H-Index: 31
#2Matthias Zeiler (Heidelberg University)H-Index: 54
Last.Marcus E. Kleber (Heidelberg University)H-Index: 51
view all 9 authors...
Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovascular Health study over a very long follow-up time of nearly 10 years. We estimated overall risk of all-cause and cardiovascular death by Cox proportional hazards regression according to quartiles of ...
#1Graciela Delgado (Heidelberg University)H-Index: 20
#2Marcus E. Kleber (Heidelberg University)H-Index: 51
Last.Alexander Lammert (Heidelberg University)H-Index: 10
view all 12 authors...
Background In a pilot study, we evaluated the efficacy of two days of oatmeal on insulin resistance and glucose metabolism and found a marked decrease of insulin requirements. The most important shortcoming of that study was that the interventions were not isocaloric (diabetes adapted diet: 1500 kcal/d vs. oatmeal 1100 kcal/d). To address these drawbacks we designed the OatMeal And Insulin Resistance (OMA-IR) study. Methods The study was a randomized, open label crossover dietary intervention st...
2 CitationsSource
#1Adrienne Tin (Johns Hopkins University)H-Index: 18
#2Adrienne Tin (Johns Hopkins University)H-Index: 5
Last.Anna Köttgen (Johns Hopkins University)H-Index: 52
view all 225 authors...
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for p...
4 CitationsSource
#1Tao Huang (PKU: Peking University)H-Index: 29
#2Tiange Wang (Tulane University)
Last.Lu Qi (Tulane University)H-Index: 73
view all 134 authors...
Importance Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. Design, Setting, and Participants This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleo...