Graciela Delgado
Heidelberg University
89Publications
19H-index
3,747Citations
Publications 89
Newest
Published on Jan 24, 2019in Scientific Reports 4.12
Claudia Sommerer29
Estimated H-index: 29
(Heidelberg University),
Matthias Zeiler51
Estimated H-index: 51
(Heidelberg University)
+ 6 AuthorsMarcus E. Kleber45
Estimated H-index: 45
(Heidelberg University)
Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovascular Health study over a very long follow-up time of nearly 10 years. We estimated overall risk of all-cause and cardiovascular death by Cox proportional hazards regression according to quartiles of ...
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Published on Feb 28, 2019in Blood 15.13
Paul S. de Vries13
Estimated H-index: 13
(University of Texas Health Science Center at Houston),
Maria Sabater-Lleal18
Estimated H-index: 18
(Karolinska Institutet)
+ 42 AuthorsJohn D. Eicher17
Estimated H-index: 17
(National Institutes of Health)
Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combin...
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Published on Jan 29, 2019in Circulation 18.88
Maria Sabater-Lleal18
Estimated H-index: 18
(Karolinska University Hospital),
Jennifer E. Huffman40
Estimated H-index: 40
+ 73 AuthorsStella Trompet44
Estimated H-index: 44
(Leiden University Medical Center)
Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. Methods: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hispanic ancestry. All studies performed linear regression analysis using an additive genetic model an...
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Published on Mar 1, 2019in Atherosclerosis 4.47
Günther Silbernagel1
Estimated H-index: 1
(Charité),
Hubert Scharnagl39
Estimated H-index: 39
(Medical University of Graz)
+ 10 AuthorsUlf Landmesser71
Estimated H-index: 71
(Charité)
Abstract Background and aims High concentrations of low density lipoprotein (LDL) triglycerides have been associated with prevalent angiographic coronary artery disease. The present analysis was designed to investigate the association of LDL triglycerides with cardiovascular mortality and to explore possible mechanisms that may link LDL triglycerides to cardiovascular risk. Methods LDL triglycerides were measured in 3140 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) stu...
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Published on Feb 1, 2019in JAMA Cardiology
Christina Ellervik21
Estimated H-index: 21
(University of Copenhagen),
Carolina Roselli7
Estimated H-index: 7
(Broad Institute)
+ 43 AuthorsXiaosen Guo53
Estimated H-index: 53
(University of California, Los Angeles)
Importance Increased free thyroxine (FT 4 ) and decreased thyrotropin are associated with increased risk of atrial fibrillation (AF) in observational studies, but direct involvement is unclear. Objective To evaluate the potential direct involvement of thyroid traits on AF. Design, Setting, and Participants Study-level mendelian randomization (MR) included 11 studies, and summary-level MR included 55 114 AF cases and 482 295 referents, all of European ancestry. Exposures Genomewide significant va...
2 Citations Source Cite
Published on Feb 26, 2019in Scientific Reports 4.12
Boris Schmitz9
Estimated H-index: 9
,
Marcus E. Kleber45
Estimated H-index: 45
(University of Jena)
+ 8 AuthorsWinfried März85
Estimated H-index: 85
(Medical University of Graz)
Chronic kidney disease (CKD) is an independent risk factor for onset and progression of coronary artery disease (CAD). Discovery of predisposing loci for kidney function in CAD patients was performed using a genome-wide association approach. Inclusion criteria were CAD with ≥50% stenosis (≥1 coronary artery) and a creatinine-based estimated glomerular filtration rate (eGFR) of 30–75 ml/min/1.73 m2. An association of rs139401390 located to a region 58.8 kb upstream of renalase (RNLS) with eGFR wa...
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Published on Mar 1, 2018in Journal of the American College of Cardiology 16.83
Guenther Silbernagel24
Estimated H-index: 24
,
Hubert Scharnagl39
Estimated H-index: 39
+ 8 AuthorsWinfried März85
Estimated H-index: 85
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Graciela Delgado19
Estimated H-index: 19
(Heidelberg University),
Marcus E. Kleber45
Estimated H-index: 45
(Heidelberg University)
+ 9 AuthorsWinfried März85
Estimated H-index: 85
(University of Graz)
Background In a pilot study, we evaluated the efficacy of two days of oatmeal on insulin resistance and glucose metabolism and found a marked decrease of insulin requirements. The most important shortcoming of that study was that the interventions were not isocaloric (diabetes adapted diet: 1500 kcal/d vs. oatmeal 1100 kcal/d). To address these drawbacks we designed the OatMeal And Insulin Resistance (OMA-IR) study. Methods The study was a randomized, open label crossover dietary intervention st...
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Anna L. Eriksson13
Estimated H-index: 13
(University of Gothenburg),
John Perry61
Estimated H-index: 61
(University of Exeter)
+ 37 AuthorsMarcus E. Kleber45
Estimated H-index: 45
(Heidelberg University)
Context: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability.Objective: To investigate the genetic regulation of serum E2 and E1 in men.Design, Setting, and Participants: Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts.Main Outcome Measures: Genetic determinants of serum E2 and E1 levels.Results: Variants in/near CYP19A1 demonstrated the strongest evidence for association with E2, resolving to three independent signals. T...
5 Citations Source Cite
Published on Apr 1, 2018in The Lancet 53.25
Marcus E. Kleber45
Estimated H-index: 45
(Heidelberg University),
Graciela Delgado19
Estimated H-index: 19
(Heidelberg University)
+ 2 AuthorsWinfried März85
Estimated H-index: 85
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