P.2.f.028 Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site, randomised controlled trial

Major depressive disorder (MDD) exerts a high health and financial burden on society. The conventional pharmacotherapies for MDD are partially effective and the response to medication often starts with some delay. There are recent reports of antidepressant effects for oral ketamine.We employed a double-blind controlled trial to examine the time course of the therapeutic effect of ketamine when combined with the conventional administration of...