Homocysteine influences blood clot properties alone and in combination with total fibrinogen but not with fibrinogen γ′ in Africans

Simultaneously increased fibrinogen and homocysteine (Hcy) in blood are believed to elevate the risk of cardiovascular disease mortality. However, the pathophysiological mechanisms involved are unknown. We sought to determine whether Hcy or its genetic determinants influence blood clot properties alone or in combination with fibrinogen. In addition, we investigated, for the first time, the gamma prime (γ′) isoform of fibrinogen with Hcy in...