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Cornelie Nienaber-Rousseau
North-West University
12Publications
4H-index
43Citations
Publications 12
Newest
#1Po Ukegbu (NWU: North-West University)
#2Herculina Salome Kruger (NWU: North-West University)H-Index: 20
Last.Mi Kruger (NWU: North-West University)
view all 7 authors...
Background: Sarcopenia, the loss of muscle mass and strength, is associated with adverse health outcomes. Calf circumference (CC) has been proposed as a surrogate measure of muscle mass in the elderly; however, ethnic/sex specific cut-off values remain to be established.Objective: A study was undertaken to investigate the relationship between CC and appendicular skeletal muscle mass (ASM), and the ASM index (ASMI), as well as to determine whether CC could be used to diagnose sarcopenia.Methods: ...
Low 25-hydroxyvitamin D (25(OH)D) and elevated C-reactive protein (CRP) concentrations are independently associated with adverse health outcomes, including cardiovascular disease (CVD). Although an inverse association between these factors has been described, the underlying mechanisms remain unknown. We postulate that environment–gene interactions, through which 25(OH)D interacts with single nucleotide polymorphisms (SNPs) within the CRP gene, modulate CRP; that certain CRP genotypes predispose ...
#1H. Toinét Cronjé (NWU: North-West University)H-Index: 1
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 4
Last.Marlien Pieters (NWU: North-West University)H-Index: 14
view all 6 authors...
Interleukin-6 (IL-6) induces the expression of fibrinogen, and polymorphic variation within the fibrinogen genes is believed to alter the magnitude of this expression. The identification of the functional relevance of individual fibrinogen single nucleotide polymorphisms (SNPs) has been hindered by the high linkage disequilibrium (LD) reported in the European fibrinogen gene locus. This study investigated two novel and 12 known fibrinogen SNPs of potential functional relevance, in 2010 Tswana in...
The rising prevalence of obesity and excessive adiposity are global public health concerns. Understanding determinants of changes in adiposity over time is critical for informing effective evidence-based prevention or treatment. However, limited information is available to achieve this objective. Cultural, demographic, environmental, and behavioral factors including socio-economic status (SES) likely account for obesity development. To this end, we related these variables to anthropometric measu...
#1H. Toinét Cronjé (NWU: North-West University)H-Index: 1
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 4
Last.Marlien Pieters (NWU: North-West University)H-Index: 14
view all 7 authors...
Abstract Fibrinogen and its functional aspects have been linked to cardiovascular disease. There is vast discrepancy between the heritability of fibrinogen concentrations observed in twin studies and the heritability uncovered by genome wide association studies. We postulate that some of the missing heritability might be explained by the pleiotropic and polygenic co-regulation of fibrinogen through multiple targeted genes, apart from the fibrinogen genes themselves. To this end we investigated s...
#1Sunelle A. Barnard (NWU: North-West University)H-Index: 3
#2Marlien Pieters (NWU: North-West University)H-Index: 14
Last.Herculina Salome Kruger (NWU: North-West University)H-Index: 20
view all 4 authors...
Abstract Introduction Although the relationship of plasminogen activator inhibitor-1 (PAI-1) with obesity has been well established, the relationship of PAI-1 with different body fat distribution patterns is less clear particularly in non-white ethnicities. Methods We investigated the cross-sectional association of PAI-1 act with body fat % and two different body fat distribution patterns, namely sarcopenic obesity (SO) and visceral (VAT) compared to subcutaneous (SCAT) abdominal obesity, in 246...
#1Ané Jobse (NWU: North-West University)H-Index: 1
#2Marlien Pieters (NWU: North-West University)H-Index: 14
Last.Moniek P.M. de Maat (EUR: Erasmus University Rotterdam)H-Index: 46
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Abstract Introduction Increased fibrinogen is associated with cardiovascular disease risk. It is, however, not known to what extend environmental and genetic factors and/or their interaction influence changes in total and γ' fibrinogen over time. We aimed to determine how variation within the fibrinogen gene as well as environmental factors influence the change in total and γ' fibrinogen over time, and also whether gene-environment interactions influence total and γ' fibrinogen on a cross-sectio...
#1Retha C.M. Kotzé (NWU: North-West University)H-Index: 4
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 4
Last.Marlien Pieters (NWU: North-West University)H-Index: 14
view all 6 authors...
Summary Inter-ethnic variation in fibrinogen levels is hypothesized to be the result of differences in genetic background. No information is available regarding the contribution of genetics to fibrinogen γ′ in Africans. Only limited information is available regarding the interaction between genotypes and total and γ′ fibrinogen concentration in determining fibrin clot properties. Our aim was to investigate the effect of polymorphisms in the fibrinogen and Factor XIII genes on total and γ′ fibrin...
#2Bianca SwanepoelH-Index: 4
Last.G.W. TowersH-Index: 2
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Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single nucleotide polymorphisms (SNPs) in the CRP gene. We determined 12 CRP SNPs, as well as various nutrition status markers in 2010 black South Africans and analyzed their...
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