Cornelie Nienaber-Rousseau
North-West University
12Publications
4H-index
41Citations
Publications 12
Newest
Published on Sep 2, 2018in South African Medical Journal
Po Ukegbu (North-West University), Herculina Salome Kruger19
Estimated H-index: 19
(North-West University)
+ 4 AuthorsMi Kruger (North-West University)
Background: Sarcopenia, the loss of muscle mass and strength, is associated with adverse health outcomes. Calf circumference (CC) has been proposed as a surrogate measure of muscle mass in the elderly; however, ethnic/sex specific cut-off values remain to be established.Objective: A study was undertaken to investigate the relationship between CC and appendicular skeletal muscle mass (ASM), and the ASM index (ASMI), as well as to determine whether CC could be used to diagnose sarcopenia.Methods: ...
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Pieter H. Myburgh , G. Wayne Towers6
Estimated H-index: 6
+ 1 AuthorsCornelie Nienaber-Rousseau4
Estimated H-index: 4
Low 25-hydroxyvitamin D (25(OH)D) and elevated C-reactive protein (CRP) concentrations are independently associated with adverse health outcomes, including cardiovascular disease (CVD). Although an inverse association between these factors has been described, the underlying mechanisms remain unknown. We postulate that environment–gene interactions, through which 25(OH)D interacts with single nucleotide polymorphisms (SNPs) within the CRP gene, modulate CRP; that certain CRP genotypes predispose ...
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Published on Nov 3, 2017in PLOS ONE 2.77
H. Toinét Cronjé1
Estimated H-index: 1
(North-West University),
Cornelie Nienaber-Rousseau4
Estimated H-index: 4
(North-West University)
+ 3 AuthorsMarlien Pieters14
Estimated H-index: 14
(North-West University)
Interleukin-6 (IL-6) induces the expression of fibrinogen, and polymorphic variation within the fibrinogen genes is believed to alter the magnitude of this expression. The identification of the functional relevance of individual fibrinogen single nucleotide polymorphisms (SNPs) has been hindered by the high linkage disequilibrium (LD) reported in the European fibrinogen gene locus. This study investigated two novel and 12 known fibrinogen SNPs of potential functional relevance, in 2010 Tswana in...
1 Citations Source Cite
Published on Jul 1, 2017in Matrix Biology 8.14
H. Toinét Cronjé1
Estimated H-index: 1
(North-West University),
Cornelie Nienaber-Rousseau4
Estimated H-index: 4
(North-West University)
+ 4 AuthorsMarlien Pieters14
Estimated H-index: 14
(North-West University)
Abstract Fibrinogen and its functional aspects have been linked to cardiovascular disease. There is vast discrepancy between the heritability of fibrinogen concentrations observed in twin studies and the heritability uncovered by genome wide association studies. We postulate that some of the missing heritability might be explained by the pleiotropic and polygenic co-regulation of fibrinogen through multiple targeted genes, apart from the fibrinogen genes themselves. To this end we investigated s...
1 Citations Source Cite
Cornelie Nienaber-Rousseau4
Estimated H-index: 4
,
Olusola F. Sotunde2
Estimated H-index: 2
+ 6 AuthorsH. Salome Kruger12
Estimated H-index: 12
The rising prevalence of obesity and excessive adiposity are global public health concerns. Understanding determinants of changes in adiposity over time is critical for informing effective evidence-based prevention or treatment. However, limited information is available to achieve this objective. Cultural, demographic, environmental, and behavioral factors including socio-economic status (SES) likely account for obesity development. To this end, we related these variables to anthropometric measu...
4 Citations Source Cite
Published on Oct 1, 2016in Thrombosis Research 2.78
Sunelle A. Barnard2
Estimated H-index: 2
(North-West University),
Marlien Pieters14
Estimated H-index: 14
(North-West University)
+ 1 AuthorsHerculina Salome Kruger19
Estimated H-index: 19
(North-West University)
Abstract Introduction Although the relationship of plasminogen activator inhibitor-1 (PAI-1) with obesity has been well established, the relationship of PAI-1 with different body fat distribution patterns is less clear particularly in non-white ethnicities. Methods We investigated the cross-sectional association of PAI-1 act with body fat % and two different body fat distribution patterns, namely sarcopenic obesity (SO) and visceral (VAT) compared to subcutaneous (SCAT) abdominal obesity, in 246...
2 Citations Source Cite
Published on Jan 1, 2015in British Journal of Haematology 5.13
Retha C.M. Kotzé4
Estimated H-index: 4
(North-West University),
Cornelie Nienaber-Rousseau4
Estimated H-index: 4
(North-West University)
+ 3 AuthorsMarlien Pieters14
Estimated H-index: 14
(North-West University)
Summary Inter-ethnic variation in fibrinogen levels is hypothesized to be the result of differences in genetic background. No information is available regarding the contribution of genetics to fibrinogen γ′ in Africans. Only limited information is available regarding the interaction between genotypes and total and γ′ fibrinogen concentration in determining fibrin clot properties. Our aim was to investigate the effect of polymorphisms in the fibrinogen and Factor XIII genes on total and γ′ fibrin...
6 Citations Source Cite
Published on Apr 1, 2015in Thrombosis Research 2.78
Ané Jobse1
Estimated H-index: 1
(North-West University),
Marlien Pieters14
Estimated H-index: 14
(North-West University)
+ 3 AuthorsMoniek P.M. de Maat44
Estimated H-index: 44
(Erasmus University Rotterdam)
Abstract Introduction Increased fibrinogen is associated with cardiovascular disease risk. It is, however, not known to what extend environmental and genetic factors and/or their interaction influence changes in total and γ' fibrinogen over time. We aimed to determine how variation within the fibrinogen gene as well as environmental factors influence the change in total and γ' fibrinogen over time, and also whether gene-environment interactions influence total and γ' fibrinogen on a cross-sectio...
1 Citations Source Cite
Published on Nov 11, 2014in Nutrients 4.20
Cornelie Nienaber-Rousseau4
Estimated H-index: 4
,
Bianca Swanepoel3
Estimated H-index: 3
+ 3 AuthorsG. Towers1
Estimated H-index: 1
Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single nucleotide polymorphisms (SNPs) in the CRP gene. We determined 12 CRP SNPs, as well as various nutrition status markers in 2010 black South Africans and analyzed their...
7 Citations Source Cite
Cornelie Nienaber-Rousseau4
Estimated H-index: 4
(North-West University)
Hyperhomocysteinaemia is implicated in various diseases, including cardiovascular disease and cancer. Several conditions influence the concentration of homocysteine (Hcy), including demographic, genetic and lifestyle factors. With regard to the latter, dietary components may be manipulated as Hcy can be remethylated to methionine by folate, or metabolised by other one‑carbon nutrients, such as betaine and its precursor, choline. This metabolic interplay enables the nutritionist or dietitian to b...
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