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Zelda de Lange
North-West University
Single-nucleotide polymorphismFibrinogenPlasminogen activator inhibitor-1FibrinMedicine
14Publications
6H-index
77Citations
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Publications 14
Newest
#1Ali DaraeiH-Index: 3
Last. Martin GutholdH-Index: 29
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#1Marlien Pieters (NWU: North-West University)H-Index: 17
#2Martin Guthold (Wake Forest University)H-Index: 29
Last. Zelda de Lange (NWU: North-West University)H-Index: 6
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Turbidimetry is used to characterize fibrin clot properties. In purified systems, maximum absorbance (MA) directly relates to fibrin fiber cross-sectional area. However, in plasma samples there are discrepancies in the relationships between MA and fibrinogen concentration, fiber diameter, other clot properties, and cardiovascular disease outcomes, which complicate data interpretation. This study aims to advance understanding of MA of plasma clots through testing how well it relates to fundamenta...
Source
#1H. Toinét Cronjé (NWU: North-West University)H-Index: 2
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 5
Last. Marlien Pieters (NWU: North-West University)H-Index: 17
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Interleukin-6 (IL-6) induces the expression of fibrinogen, and polymorphic variation within the fibrinogen genes is believed to alter the magnitude of this expression. The identification of the functional relevance of individual fibrinogen single nucleotide polymorphisms (SNPs) has been hindered by the high linkage disequilibrium (LD) reported in the European fibrinogen gene locus. This study investigated two novel and 12 known fibrinogen SNPs of potential functional relevance, in 2010 Tswana in...
1 CitationsSource
#1H. Toinét Cronjé (NWU: North-West University)H-Index: 2
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 5
Last. Marlien Pieters (NWU: North-West University)H-Index: 17
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Abstract Fibrinogen and its functional aspects have been linked to cardiovascular disease. There is vast discrepancy between the heritability of fibrinogen concentrations observed in twin studies and the heritability uncovered by genome wide association studies. We postulate that some of the missing heritability might be explained by the pleiotropic and polygenic co-regulation of fibrinogen through multiple targeted genes, apart from the fibrinogen genes themselves. To this end we investigated s...
2 CitationsSource
#1Sunelle A. Barnard (NWU: North-West University)H-Index: 3
#2Marlien Pieters (NWU: North-West University)H-Index: 17
Last. Zelda de Lange (NWU: North-West University)H-Index: 6
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Increased plasma plasminogen activator inhibitor-1 (PAI-1) level is considered a mechanistic pathway through which obesity contributes to increased cardiovascular disease risk. Abdominal adipose tissue specifically, is a major PAI-1 source with visceral adipose tissue (VAT), an ectopic fat depot, generally considered to produce more PAI-1 than subcutaneous adipose tissue. However, this does not necessarily lead to increased plasma PAI-1 levels. This review provides an overview of studies investi...
10 CitationsSource
#1Albe C. Swanepoel (University of Pretoria)H-Index: 11
#2Amcois Visagie (University of Pretoria)H-Index: 3
Last. Etheresia Pretorius (University of Pretoria)H-Index: 35
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Swanepoel received funding from the National Research Foundation (NRF) of South Africa and Pretorius received funding from the Medical Research Council (MRC) of South Africa.
7 CitationsSource
#1Philna Eksteen (NWU: North-West University)H-Index: 1
#2Marlien Pieters (NWU: North-West University)H-Index: 17
Last. Herculina S. Kruger (NWU: North-West University)H-Index: 23
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Abstract Introduction Preliminary evidence indicates that the association of fibrinolytic potential, measured as clot lysis time (CLT), with body composition may differ from that of plasminogen activator inhibitor type-1 (PAI-1). We therefore investigated the association between fibrinolytic markers (plasminogen activator inhibitor type-1 activity (PAI-1 act ) and CLT) and body composition using detailed body composition analyses. Materials and methods Data from 1288 Africans were cross-sectiona...
5 CitationsSource
: Simultaneously increased fibrinogen and homocysteine (Hcy) in blood are believed to elevate the risk of cardiovascular disease mortality. However, the pathophysiological mechanisms involved are unknown. We sought to determine whether Hcy or its genetic determinants influence blood clot properties alone or in combination with fibrinogen. In addition, we investigated, for the first time, the gamma prime (γ') isoform of fibrinogen with Hcy in relation to clot architecture and lysis. Single-nucleo...
2 CitationsSource
#1Retha C. M. Kotze (NWU: North-West University)H-Index: 4
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 5
Last. Marlien Pieters (NWU: North-West University)H-Index: 17
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Summary Inter-ethnic variation in fibrinogen levels is hypothesized to be the result of differences in genetic background. No information is available regarding the contribution of genetics to fibrinogen γ′ in Africans. Only limited information is available regarding the interaction between genotypes and total and γ′ fibrinogen concentration in determining fibrin clot properties. Our aim was to investigate the effect of polymorphisms in the fibrinogen and Factor XIII genes on total and γ′ fibrin...
7 CitationsSource
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