Chronic stress is linked to 5-HT1A receptor changes and functional disintegration of the limbic networks

There are increasing reports about stress related cognitive and psychic declines in subjects who have no psychiatric premorbidity, depression, or major life trauma. Yet, little is known about the underlying neurobiology. Based on the typical symptomatology, fMRI data suggesting that stress activates the limbic circuits, and animal data showing a major involvement of the 5-HT1A receptor in stress regulation, we hypothesized that enduring daily...