The relationship between subjective effects induced by a single dose of ketamine and treatment response in patients with major depressive disorder: A systematic review

The relationship between ketamine's hallucinogenic- and dissociative-type effects and antidepressant mechanism of action is poorly understood. This paper reviewed the correlation between subjective effects defined by various psychometric scales and observed clinical outcomes in the treatment of patients with Major Depressive Disorder (MDD). Based on PRISMA guidelines, we reviewed the dissociative and psychotomimetic mental state induced with...