Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not pr esent until irreversible pathological changes have occurred. Given an opportunity to provide treatment prior to irreversible pathological change,...