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S-Adenosylmethionine (SAMe) monotherapy for depression: an 8-week double-blind, randomised, controlled trial.

Published on Jan 1, 2020in Psychopharmacology3.424
· DOI :10.1007/s00213-019-05358-1
Jerome Sarris29
Estimated H-index: 29
(USYD: University of Sydney),
Jenifer Murphy7
Estimated H-index: 7
(University of Melbourne)
+ 13 AuthorsGerard J. Byrne31
Estimated H-index: 31
(Royal Brisbane and Women's Hospital)
Abstract
Rationale Dysregulation of the one carbon cycle is documented in depression. Thereby, S-adenosylmethionine (SAMe), a one–carbon cycle nutraceutical compound with a favourable side effect profile, has a theoretical rationale for efficacy. However, further controlled studies are required to confirm SAMe’s efficacy.
  • References (28)
  • Citations (1)
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References28
Newest
#1Jerome Sarris (USYD: University of Sydney)H-Index: 29
#2Gerard J. Byrne (UQ: University of Queensland)H-Index: 31
Last. David Mischoulon (Harvard University)H-Index: 43
view all 16 authors...
Abstract There has been increasing interest in nutraceutical augmentation strategies to boost the efficacy of antidepressants. This study assessed whether S-adenosylmethionine (SAMe), a methyl donor that occurs naturally in the body, may be of such benefit. We conducted an 8-week, double-blind RCT in which 107 treatment non-remittent outpatients with DSM-5 diagnosed Major Depressive Disorder (MDD) were randomized to either SAMe or placebo adjunctively to antidepressants. One-carbon cycle nutrien...
6 CitationsSource
#1Janus Christian Jakobsen (Copenhagen University Hospital)H-Index: 17
#2Kiran Kumar Katakam (Copenhagen University Hospital)H-Index: 4
Last. Christian Gluud (Copenhagen University Hospital)H-Index: 77
view all 15 authors...
The evidence on selective serotonin reuptake inhibitors (SSRIs) for major depressive disorder is unclear. Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo, ‘active’ placebo, or no intervention in adult participants with major depressive disorder. We searched for eligible randomised clinical trials in The Cochrane Library’s CENTRAL, PubMed, EMBASE, PsycLIT, PsycINFO, Science Citation Index Expanded, clinical trial registers of Europe and USA, websites...
74 CitationsSource
#1de Sousa DpH-Index: 36
Last. Elaine C. GavioliH-Index: 23
view all 4 authors...
Depression is a disease that has affected a high proportion of the world’s population and people of different ages, incapacitating them from good performance at work and in social relationships, and causing emotional disorders to millions of families. Therefore, the search for new therapeutic agents is considered a priority for the discovery of more effective forms of treatment. In this review, studies of essential oils and their constituents in experimental models related to depression are disc...
5 CitationsSource
20 CitationsSource
#1Thomas Frodl (Otto-von-Guericke University Magdeburg)H-Index: 52
Major depressive disorder is one of the leading causes of disability in the world since depression is highly frequent and causes a strong burden. In order to reduce the duration of depressive episodes, clinicians would need to choose the most effective therapy for each individual right away. A prerequisite for this would be to have biomarkers at hand that would predict which individual would benefit from which kind of therapy (for example, pharmacotherapy or psychotherapy) or even from which kin...
7 CitationsSource
#1Ilaria Galizia ('KCL': King's College London)H-Index: 2
#2Lucio Oldani (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 8
Last. Allan H. Young ('KCL': King's College London)H-Index: 75
view all 10 authors...
Background Depression is a recurrent illness with high rates of chronicity, treatment-resistance and significant economic impact. There is evidence in the literature that S-adenosyl methionine (SAMe), a naturally occurring compound in the human body, has antidepressant efficacy. This product may be an important addition to the armamentarium of antidepressant agents. Objectives To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults. S...
19 CitationsSource
#1Jerome SarrisH-Index: 29
#2Jenifer MurphyH-Index: 7
Last. Chee H. NgH-Index: 19
view all 7 authors...
Objective:There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants. The adjunctive use of standardized pharmaceutical-grade nutrients, known as nutraceuticals, has the potential to modulate several neurochemical pathways implicated in depression. While many studies have been conducted in this area, to date no specialized systematic review (or meta-analysis) has been conducted.Method:A systematic search of PubMed, CINAHL, Cochrane Library, and W...
102 CitationsSource
#1Jerome Sarris (Swinburne University of Technology)H-Index: 29
#2Lawrence H. Price (Brown University)H-Index: 88
Last. David Mischoulon (Harvard University)H-Index: 43
view all 9 authors...
Objective: The aim of this study was to examine whether gender differences may have affected treatment response to S-adenosyl methionine (SAMe) in a recent failed randomized clinical trial (RCT) for adults with major depressive disorder. Methods: Data from a 2-site, 12-week, double-blind RCT (n=189) assessing the efficacy of SAMe vs. placebo and a comparator selective serotonin reuptake inhibitor (escitalopram) were subjected to post-hoc analyses to evaluate effects of patient gender on treatmen...
17 CitationsSource
#1Rachael I. RosnerH-Index: 1
269 CitationsSource
#1Jerome Sarris (Swinburne University of Technology)H-Index: 29
#2George I. Papakostas (Harvard University)H-Index: 49
Last. David Mischoulon (Harvard University)H-Index: 43
view all 5 authors...
Abstract Objective To assess the antidepressant efficacy of S-adenosyl methionine (SAMe), a naturally occurring methyl donor, versus the selective serotonin reuptake inhibitor (SSRI) escitalopram and a placebo control; and to determine whether serum histamine or carnitine levels modified treatment response. Methods We examined a subsample ( n =144) from one site of a two-site study of adults with diagnosed Major Depressive Disorder (MDD), recruited from 4/13/05 to 12/22/09, who consented to the ...
27 CitationsSource
Cited By1
Newest
In previous studies, we produced changes in gene expression in the brain of mice by early postnatal administration of valproic acid (VPA), with distinct differences between genders. The addition of S-adenosine methionine (SAMe) normalized the expression of most genes in both genders, while SAMe alone induced no changes. We treated pregnant dams with a single injection of VPA on day 12.5 of gestation, or with SAMe during gestational days 12–14, or by a combination of VPA and SAMe. In the frontal ...
1 CitationsSource