S-Adenosylmethionine (SAMe) monotherapy for depression: an 8-week double-blind, randomised, controlled trial.

Published on Jan 1, 2020in Psychopharmacology3.424
· DOI :10.1007/s00213-019-05358-1
Jerome Sarris29
Estimated H-index: 29
(USYD: University of Sydney),
Jenifer Murphy7
Estimated H-index: 7
(University of Melbourne)
+ 13 AuthorsGerard J. Byrne31
Estimated H-index: 31
(Royal Brisbane and Women's Hospital)
Rationale Dysregulation of the one carbon cycle is documented in depression. Thereby, S-adenosylmethionine (SAMe), a one–carbon cycle nutraceutical compound with a favourable side effect profile, has a theoretical rationale for efficacy. However, further controlled studies are required to confirm SAMe’s efficacy.
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  • Citations (1)
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