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Jenifer Murphy
University of Melbourne
PsychiatryRandomized controlled trialPlaceboMajor depressive disorderMedicine
20Publications
7H-index
236Citations
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Publications 23
Newest
#1Jerome Sarris (USYD: University of Sydney)H-Index: 29
#2Gerard J. Byrne (UQ: University of Queensland)H-Index: 31
Last. Con Stough (Swinburne University of Technology)H-Index: 49
view all 16 authors...
Objective:Previous randomised, double-blind, placebo-controlled studies have shown that Kava (a South Pacific medicinal plant) reduced anxiety during short-term administration. The objective of thi...
Source
#1Jerome Sarris (USYD: University of Sydney)H-Index: 29
#2Jenifer Murphy (University of Melbourne)H-Index: 7
Last. Gerard J. Byrne (Royal Brisbane and Women's Hospital)H-Index: 31
view all 16 authors...
Rationale Dysregulation of the one carbon cycle is documented in depression. Thereby, S-adenosylmethionine (SAMe), a one–carbon cycle nutraceutical compound with a favourable side effect profile, has a theoretical rationale for efficacy. However, further controlled studies are required to confirm SAMe’s efficacy.
1 CitationsSource
#1Kiki P. van der Burg (UU: Utrecht University)H-Index: 1
#2Lachlan Cribb (University of Melbourne)H-Index: 3
Last. Jerome Sarris (USYD: University of Sydney)H-Index: 29
view all 13 authors...
Purpose Depression clinical trials are increasingly studying biomarkers to predict and monitor response to treatment. Assessment of biomarkers may reveal subsets of patients who are responsive to nutraceutical treatment, which may facilitate a personalized approach to treating depression.
1 CitationsSource
#1Jenifer Murphy (University of Melbourne)H-Index: 7
#2Georgina Oliver (University of Melbourne)H-Index: 6
Last. Jerome Sarris (USYD: University of Sydney)H-Index: 29
view all 8 authors...
Background: Metabolic syndrome and co-morbid physical health conditions are highly prevalent in people with a mental illness. Modifiable lifestyle factors have been targeted to improve health outcomes. Healthy Body Healthy Mind (HBHM) program was developed to provide an integrated evidence-based program incorporating practical diet and exercise instruction; alongside meditation and mindfulness strategies, and comprehensive psychoeducation, to improve the physical and mental health of those with ...
1 CitationsSource
#1Jerome Sarris (USYD: University of Sydney)H-Index: 29
#2Gerard J. Byrne (UQ: University of Queensland)H-Index: 31
Last. Chee H. Ng (University of Melbourne)H-Index: 19
view all 14 authors...
Abstract Partial or non-response to antidepressants in Generalized Anxiety Disorder (GAD) is common in clinical settings, and adjunctive biological interventions may be required. Adjunctive herbal and nutraceutical treatments are a novel and promising treatment option. L-theanine is a non-protein amino acid derived most-commonly from tea (Camellia sinensis) leaves, which may be beneficial in the treatment of anxiety and sleep disturbance as suggested by preliminary evidence. We conducted a 10-we...
2 CitationsSource
#1Jerome Sarris (USYD: University of Sydney)H-Index: 29
#2Gerard J. Byrne (UQ: University of Queensland)H-Index: 31
Last. Chee H. Ng (University of Melbourne)H-Index: 19
view all 16 authors...
Abstract Background One of the most pressing questions in “Nutritional Psychiatry” is whether using combinations of different nutraceuticals with putative antidepressant activity may provide an enhanced synergistic antidepressant effect. Methods A phase II/III, Australian multi-site, 8-week, double-blind, RCT involving 158 outpatients with a DSM-5 diagnosis of MDD. The intervention consisted of a nutraceutical combination: S-adenosyl methionine; Folinic acid; Omega-3 fatty acids; 5-HTP, Zinc pic...
7 CitationsSource
#1Jerome Sarris (USYD: University of Sydney)H-Index: 29
#2Gerard J. Byrne (UQ: University of Queensland)H-Index: 31
Last. David Mischoulon (Harvard University)H-Index: 43
view all 16 authors...
Abstract There has been increasing interest in nutraceutical augmentation strategies to boost the efficacy of antidepressants. This study assessed whether S-adenosylmethionine (SAMe), a methyl donor that occurs naturally in the body, may be of such benefit. We conducted an 8-week, double-blind RCT in which 107 treatment non-remittent outpatients with DSM-5 diagnosed Major Depressive Disorder (MDD) were randomized to either SAMe or placebo adjunctively to antidepressants. One-carbon cycle nutrien...
6 CitationsSource
#1Amy Froud (University of Melbourne)H-Index: 1
#2Jenifer Murphy (University of Melbourne)H-Index: 7
Last. Jerome Sarris (University of Melbourne)H-Index: 29
view all 5 authors...
Background: Brain-derived neurotrophic factor (BDNF), a neurotrophic factor implicated in the pathogenesis of depression, may be influenced by dietary quality. Both dietary quality and serum BDNF have been researched independently in regard to their effect on depression; however, there is limited research investigating the relationship between the two factors and how they interact in depression. Additionally, a single-nucleotide polymorphism (SNP) (Val66Met) in the BDNF gene, which has been impl...
Source
#1Ranjit Menon (University of Melbourne)H-Index: 4
#2Lachlan Cribb (University of Melbourne)H-Index: 3
Last. Jerome Sarris (USYD: University of Sydney)H-Index: 29
view all 11 authors...
Abstract Introduction Recent evidence suggests that mitochondrial dysfunction may play a role in the pathophysiology of chronic fatigue syndrome (CFS). We undertook a pilot investigation of a combination of nutraceutical nutrient compounds which are involved in mitochondrial function and energy generation, to assess their efficacy in improving symptoms of CFS. An open-label design was employed as CFS is largely treatment-resistant with limited placebo-response. Methods A 16-week open-label trial...
1 CitationsSource
#1Jenifer MurphyH-Index: 7
#2Jerome SarrisH-Index: 29
Last. Gerard J. ByrneH-Index: 31
view all 3 authors...
Major depression does not always remit. Difficult-to-treat depression is thought to contribute to the large disease burden posed by depression. Treatment-resistant depression (TRD) is the conventional term for nonresponse to treatment in individuals with major depression. Indicators of the phenomenon are the poor response rates to antidepressants in clinical practice and the overestimation of the efficacy of antidepressants in medical scientific literature. Current TRD staging models are based o...
8 CitationsSource
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