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Psychopharmacology
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#1Yasmine A El-Khatib (Cairo University)
#2Rabab H. Sayed (Cairo University)H-Index: 5
Last. Mahmoud M. Khattab (Cairo University)H-Index: 15
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Estradiol decline has been associated with depression and anxiety in post-menopausal women. Agomelatine (Ago) is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT2c receptors. The present study aimed to evaluate the effects of combining Ago with 17β-estradiol (E2) on ovariectomy (OVX)-induced depressive- and anxiety-like behaviors in young adult female rats. OVX rats were treated with Ago (40 mg/kg/day, p.o.) for 10 days starting 1 week after surgery alo...
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#1Danielle J. Houwing (UG: University of Groningen)H-Index: 3
#2Jolien de Waard (UG: University of Groningen)
Last. Jocelien D. A. Olivier (UG: University of Groningen)H-Index: 20
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RATIONALE Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (SCN) is known to be modulated by serotonin and it is therefore assumed that SSRIs may affect circadian rhythms. However, effects of perinatal SSRI treatment on circadian system fun...
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#1Julie A. Meade (VCU: Virginia Commonwealth University)H-Index: 2
#2Yasmin Alkhlaif (VCU: Virginia Commonwealth University)H-Index: 1
Last. M. I. Damaj (VCU: Virginia Commonwealth University)H-Index: 11
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Cancer patients receiving the antineoplastic drug paclitaxel report higher incidences and longer duration of treatment-resistant depression than patients receiving other classes of chemotherapeutics. Rodents treated with paclitaxel exhibit a suite of changes in affect-like behaviors. Further, paclitaxel causes chemotherapy-induced peripheral neuropathy (CIPN) in humans and rodents. Kappa opioid receptors (KOR) have a well-established role in depression and neuropathy. The contributions of KOR si...
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#1Mahnaz Ahmadimanesh (MUMS: Mashhad University of Medical Sciences)
#2Soudabeh Balarastaghi (MUMS: Mashhad University of Medical Sciences)H-Index: 1
Last. Rezvan Yazdian-Robati (Mazandaran University of Medical Sciences)H-Index: 7
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Depression is a major mental disorder affecting millions of people worldwide. Serotonin and norepinephrine reuptake inhibitors (SNRIs) are one of the antidepressant drugs prescribed for depression treatment. There are many contradiction studies about the adverse effect and genotoxicity of SNRIs. So here, based on the guidelines proposed at the PRISMA statement, we performed a quantitative systematic review by searching international electronic databases (PubMed, Scopus, Embase, and Web of Scienc...
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#1Nikolaos Kokras (UoA: National and Kapodistrian University of Athens)H-Index: 19
#2Chrysoula Dioli (UoA: National and Kapodistrian University of Athens)
Last. Christina Dalla (UoA: National and Kapodistrian University of Athens)H-Index: 27
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RATIONALE Νeurosteroids, like dehydroepiandrosterone (DHEA), play an important role in neurodegeneration and neural protection, but they are metabolized in androgens, estrogens, or other active metabolites. A newly developed synthetic DHEA analog, BNN27 ((20R)-3β,21-dihydroxy-17R,20-epoxy-5-pregnene), exerts neurotrophic and neuroprotective actions without estrogenic or androgenic effects. OBJECTIVES This study aimed to investigate potential anxiolytic or antidepressant properties of BNN27. METH...
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#1Sabine Steins-Loeber (University of Bamberg)H-Index: 1
#2Frank Lörsch (University of Bamberg)
Last. Oliver T. Wolf (RUB: Ruhr University Bochum)H-Index: 71
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RATIONAL The ability of conditioned stimuli to affect instrumental responding is a robust finding from animal as well as human research and is assumed as a key factor regarding the development and maintenance of addictive behaviour. OBJECTIVES While it is well known that stress is an important factor for relapse after treatment, little is known about the impact of stress on conditioned substance-associated stimuli and their influence on instrumental responding. METHODS We administered in the pre...
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#1Theresa M. Carbonaro (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 6
#2Matthew W. Johnson (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 37
Last. Roland R. Griffiths (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 73
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RATIONALE Although both psilocybin and dextromethorphan (DXM) produce psychedelic-like subjective effects, rates of non-medical use of psilocybin are consistently greater than DXM. OBJECTIVE New data are presented from a study of psilocybin and DXM relevant to understanding the features of psilocybin subjective effects that may account for its higher rates of non-medical use. METHODS Single, acute oral doses of psilocybin (10, 20, 30 mg/70 kg), DXM (400 mg/70 kg), and placebo were administered u...
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#1Anja Kräplin (TUD: Dresden University of Technology)H-Index: 6
#2Michael Höfler (TUD: Dresden University of Technology)H-Index: 53
Last. M. Smolka (TUD: Dresden University of Technology)H-Index: 51
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BACKGROUND This study investigated whether patterns of impulsive decision-making (i) differ between individuals with DSM-5 substance use disorders (SUD) or non-substance-related addictive disorders (ND) and healthy controls, and (ii) predict the increase of SUD and ND severity after one year. METHODS In a prospective-longitudinal community study, 338 individuals (19-27 years, 59% female) were included in one of three groups: SUD (n = 100), ND (n = 118), or healthy controls (n = 120). Group diffe...
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#1Samantha J. McClenahan (University of Arkansas for Medical Sciences)H-Index: 2
#2Melinda G. Gunnell (University of Arkansas for Medical Sciences)H-Index: 9
Last. William E. Fantegrossi (University of Arkansas for Medical Sciences)H-Index: 31
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RATIONALE 3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES These studies tested the capacity of active vaccination to reduce the reinforcing effects of MDPV in Sprague-Dawley rats. METHODS Rats acquired cocaine self-administration (0.32 mg/kg/inf) on an FR1 ...
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#1Lisa JeromeH-Index: 11
Last. Rick DoblinH-Index: 8
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Posttraumatic stress disorder (PTSD) is a chronic condition that has wide-ranging negative effects on an individual’s health and interpersonal relationships. Treatments with long-term benefits are needed to promote the safety and well-being of those suffering from PTSD. To examine long-term change in PTSD symptoms and additional benefits/harms after 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for treatment of PTSD. Participants received two to three active doses of MDMA (75–1...
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