Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline

The associations of 4 proteins—AK4, ITPK1, HSPB2, and IGFBP5—with cognitive function in older adults were largely unexplained by known brain pathologies. We examined the extent to which individual protein associations with cognitive decline were attributable to microstructural changes in the brain. This study included 521 participants (mean age 90.3, 65.9–108.3) with the postmortem reciprocal of transverse relaxation time (R2) magnetic resonance...