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Neurobiology of Aging
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#1Thomas Desmidt (François Rabelais University)H-Index: 6
#2Julien Delrieu (University of Toulouse)H-Index: 8
Last.Maria-Joao Ribeiro (François Rabelais University)H-Index: 1
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Abstract It remains unclear whether benzodiazepines (BZDs) constitute a risk factor for Alzheimer’s disease (AD). In this study, we investigated associations between chronic use of BZDs and brain amyloid load, a hallmark of AD, in 268 nondemented older individuals. F18-florbetapir positron emission tomography scans were performed to assess amyloid load as measured by standard uptake value ratios (SUVRs) which were compared between chronic BZD users and nonusers using adjusted multiple linear reg...
#1Elaheh MoradiH-Index: 5
#2Mikael Marttinen (University of Eastern Finland)H-Index: 4
Last.Matti NykterH-Index: 25
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Abstract Early identification and treatment of Alzheimer’s disease (AD) is hampered by the lack of easily accessible biomarkers. Currently available fluid biomarkers of AD provide indications of the disease stage; however, these are measured in the cerebrospinal fluid (CSF), requiring invasive procedures, which are not applicable at the population level. Thus, gene expression profiling of blood provides a viable alternative as a way to screen individuals at risk of AD. Previous studies have show...
#1Arman Shekari (McMaster University)H-Index: 1
#2Margaret Fahnestock (McMaster University)H-Index: 39
Abstract Basal forebrain cholinergic neurons (BFCNs) are critical for learning and memory and degenerate early in Alzheimer’s disease. BFCNs depend for their survival and function on nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) which are retrogradely transported from BFCN targets. Age is the greatest risk factor for developing Alzheimer’s disease, yet the influence of age on BFCN axonal transport is poorly understood. To model aging, embryonic rat basal forebrain or cor...
#1Xin Li (KI: Karolinska Institutet)H-Index: 1
#2Lars Bäckman (KI: Karolinska Institutet)H-Index: 83
Last.Jonas Persson (KI: Karolinska Institutet)H-Index: 35
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Abstract Dopamine (DA) in both prefrontal cortex (PFC) and caudate nucleus is critical for working memory (WM) function. The C957T and Taq1A polymorphisms of the DRD2 gene are related to DA D2 receptor densities in PFC and striatum. Using functional MRI, we investigated the relationship of age and these two DRD2 gene polymorphisms to WM function and examined possible age by gene interactions. Results demonstrated less caudate activity for older adults (70-80 years; n=112) compared to the younger...
#1Marie-Gabrielle Duperron (French Institute of Health and Medical Research)
#2Christophe Tzourio (French Institute of Health and Medical Research)H-Index: 59
Last.Stéphanie Debette (French Institute of Health and Medical Research)H-Index: 43
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Abstract Commonly observed in older community persons, dilated perivascular spaces (dPVS) are thought to represent an emerging MRI-marker of cerebral small vessel disease (cSVD), but their clinical significance is uncertain. We examined the longitudinal relationship of dPVS burden with risk of incident stroke, ischemic stroke, and intracerebral hemorrhage (ICH) in the 3C-Dijon population-based study (N=1,678 participants, mean age 72.7±4.1 years) using Cox regression. dPVS burden was studied as ...
#1Namhee KimH-Index: 13
#2Lei YuH-Index: 70
Last.David A. BennettH-Index: 152
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Abstract The associations of four proteins – AK4, ITPK1, HSPB2, and IGFBP5 – with cognitive function in older adults were largely unexplained by known brain pathologies. We examined the extent to which individual protein associations with cognitive decline were attributable to microstructural changes in the brain. This study included 521 participants (mean age 90.3, 65.9-108.3) with the postmortem reciprocal of transverse relaxation time (R2) magnetic resonance image. All participants came from ...
#1Miranka Wirth (German Center for Neurodegenerative Diseases)
#2Catharina Lange (Humboldt University of Berlin)
Last.Willem Huijbers (Tilburg University)H-Index: 19
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Abstract Hypothalamic-pituitary-adrenal (HPA) dysregulation is proposed as a risk factor for Alzheimer’s disease (AD). This study assessed cross-sectional relationships between cortisol and neuroimaging biomarkers of brain structure and glucose metabolism across the AD spectrum. Participants with normal cognition, mild cognitive impairment, and AD were selected from the Alzheimer’s Disease Neuroimaging Initiative databank, based on baseline measures of plasma cortisol concentration, gray matter ...
#1Marianne Nygaard (University of Southern Denmark)H-Index: 9
#2Martin Jakob Larsen (University of Southern Denmark)H-Index: 11
Last.Lena Christiansen (University of Southern Denmark)H-Index: 36
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Abstract Only few studies have investigated the genome-wide transcriptome of normative cognitive aging. We therefore aimed at investigating blood gene expression patterns associated with cognitive aging using a population-based sample of 235 middle-aged monozygotic twin pairs with longitudinal data on cognitive function. This unique set-up enabled examination of gene expression differences associated with individual and intra-pair differences in cognitive level and change while controlling for u...
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