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Neurobiology of Aging
IF
4.40
Papers
12176
Papers 12218
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#1Yuxi Wang (Hangzhou Normal University)
#2Yi Yang (Hangzhou Normal University)H-Index: 3
Last.Li-Hui Zhang (Hangzhou Normal University)H-Index: 12
view all 5 authors...
Abstract Neuroinflammation is a complex biological process and has been known to play an important role in age-related cerebrovascular and neurodegenerative disorders, such as cerebral ischemia, Alzheimer's disease (AD) and Parkinson's disease (PD). Cysteinyl leukotrienes (CysLTs) are potent inflammatory lipid mediators that exhibit actions mainly through activating type 1 and type 2 CysLT receptors (CysLT1 and CysLT2). Accumulating evidence shows that CysLT1 and CysLT2 are activated at differen...
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#1Zhiguang Huo (UF: University of Florida)H-Index: 1
#2Lei Yu (Rush University Medical Center)H-Index: 73
Last.Jinying Zhao (UF: University of Florida)H-Index: 21
view all 6 authors...
Abstract The development of Alzheimer’s dementia (AD) accompanies both central and peripheral metabolic disturbance, but the metabolic basis underlying AD and metabolic markers predictive of AD risk remain to be determined. It is also unclear whether the metabolic changes in peripheral blood and brain are overlapping in relation to AD. The current study addresses these questions by targeted metabolomics in both ante-mortem blood and post-mortem brain samples in two community-based longitudinal c...
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#1Deepti Chugh (The Ohio State University Wexner Medical Center)
#2Chitra C. Iyer (The Ohio State University Wexner Medical Center)H-Index: 6
Last.W. David ArnoldH-Index: 15
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Abstract Neurodegeneration has increasingly been considered an important factor in the pathogenesis of sarcopenia or age-related loss of muscle mass and strength. Experiments were designed to investigate the fidelity of neuromuscular junction (NMJ) transmission across the lifespan in hindlimb muscles of male and female C57BL/6J mice (at 12, 20, 24, 27 and 29 months of age). Single fiber electromyography recordings demonstrated abrupt onset of NMJ transmission failure at 27 months of age. Failed ...
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#1Nicola Toschi (University of Rome Tor Vergata)H-Index: 27
#2Rebeca Arrais Gisbert (CSIC: Spanish National Research Council)
Last.Silvia De Santis (Cardiff University)H-Index: 10
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Abstract During aging, human white matter (WM) is subject to dynamic structural changes which have a deep impact on healthy and pathological evolution of the brain through the lifespan; characterizing this pattern is of key importance for understanding brain development, maturation and aging as well as for studying its pathological alterations. Diffusion Magnetic Resonance Imaging (MRI) can provide a quantitative assessment of the white-matter microstructural organization that characterizes thes...
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#1Lucine Karanfilian ('KCL': King's College London)
#2Maria Grazia Tosto ('KCL': King's College London)H-Index: 11
Last.Karim Malki ('KCL': King's College London)H-Index: 14
view all 3 authors...
Abstract Alzheimer’s Disease (AD) is a pervasive, neurodegenerative disorder and a major contributor to the global burden of disease. AD pathology includes amyloid plaque formation, tau hyperphosphorylation and neuroinflammation. Several genetic studies have identified a rare variant of TREM2 (Triggering Receptor Expressed on Myeloid cells 2) as a risk factor for the disorder. Although the role of TREM2 is not fully understood, it is thought to trigger the microglial response to amyloid plaques....
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#1Claudio Babiloni (Sapienza University of Rome)H-Index: 63
#2Susanna Lopez (University of Bari)H-Index: 6
Last.Nathalie George (University of Paris)H-Index: 28
view all 24 authors...
Abstract Cognitive reserve (CR) is present in Alzheimer’s disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris), may present abnormal eyes-closed resting state posterior electroencephalographic (rsEEG) rhythms around individual alpha frequency pea...
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#1Dejan JakimovskiH-Index: 6
#2Niels BergslandH-Index: 33
Last.Bianca Weinstock-GuttmanH-Index: 73
view all 12 authors...
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#1Ying-hui Chou (UA: University of Arizona)H-Index: 11
#2Viet Ton That (UA: University of Arizona)
Last.Mark Sundman (UA: University of Arizona)H-Index: 7
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Abstract Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, has emerged as a promising treatment for mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Currently, however, the effectiveness of this therapy is unclear due to the low statistical power and heterogeneity of previous trials. The purpose of the meta-analysis was to systematically characterize the effectiveness of various combinations of rTMS parameters on different cognitive dom...
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#1Jun Yi Wang (UC Davis: University of California, Davis)H-Index: 8
#2David R Hessl (UC Davis: University of California, Davis)H-Index: 49
Last.Susan M. Rivera (UC Davis: University of California, Davis)H-Index: 35
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Abstract Ventricular enlargement (VE) is commonly observed in aging and fragile X-associated tremor/ataxia syndrome (FXTAS), a late-onset neurodegenerative disorder. VE may generate a mechanical force causing structural deformation. In this longitudinal study, we examined the relationships between VE and structural changes in the corpus callosum (CC) and putamen. MRI scans (2-7/person over 0.2-7.5 years) were acquired from 22 healthy controls, 26 unaffected premutation carriers (PFX-), and 39 ca...
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#1Louis Nadal (CNRS: Centre national de la recherche scientifique)
#2Pierrick Coupé (CNRS: Centre national de la recherche scientifique)H-Index: 34
Last.Vincent Planche (CNRS: Centre national de la recherche scientifique)
view all 9 authors...
Abstract Several studies have investigated the differential vulnerability of hippocampal subfields during aging and Alzheimer’s disease (AD). Results were often contradictory, mainly because these works were based on concatenations of cross-sectional measures in cohorts with different ages or stages of AD, in the absence of a longitudinal design. Here, we investigated 327 participants from a population-based cohort of non-demented older adults with a 14-year clinical follow-up. MRI at baseline a...
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