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Neurobiology of Aging
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#1Zhendan ZhuH-Index: 1
#2Ja ChuckowreeH-Index: 10
Last. Catherine A. BlizzardH-Index: 14
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Abstract Traumatic brain injury (TBI) can affect individuals at any age, with the potential of causing lasting neurological consequences. The lack of effective therapeutic solutions and recommendations for patients that acquire a TBI can be attributed, at least in part, to an inability to confidently predict long-term outcomes following TBI, and how the response of the brain differs across the lifespan. The purpose of this study was to determine how age specifically affects TBI outcomes in a pre...
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#1Hui Wang (HAU: Huazhong Agricultural University)
#2Jingyun Yang (Rush University Medical Center)H-Index: 24
Last. Hong-Yu Zhang (HAU: Huazhong Agricultural University)
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Abstract Genome-wide association studies have identified many loci associated with Alzheimer’s dementia. However, these variants only explain part of the heritability of Alzheimer’s disease (AD). As genetic epistasis can be a major contributor to the “missing heritability” of AD, we conducted genome-wide epistasis screening for AD pathologies in two independent cohorts. First, we performed a genome-wide epistasis study of AD-related brain pathologies (Nmax = 1,318) in ROS/MAP. Candidate interact...
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#1Wei Ling LauH-Index: 21
#2Mark FisherH-Index: 23
Last. Claudia H. KawasH-Index: 63
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Abstract Chronic kidney disease is emerging as a novel risk factor for cerebrovascular disease but this association remains largely unexplored in older adults. Cystatin C is a more accurate measure than creatinine of kidney function in the elderly. We evaluated cystatin C, cognitive function and brain imaging in 193 participants from The 90+ Study neuroimaging component. Mean age was 93.9 years; 61% were female. Mean cystatin C was 1.62 mg/L with eGFR 39.2 ml/min/1.73 m2. Performance on measures...
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#1Ane-Victoria Idland (University of Oslo)H-Index: 6
#2Roser Sala-Llonch (University of Barcelona)H-Index: 24
Last. Torgeir Bruun Wyller (University of Oslo)H-Index: 39
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Abstract Brain changes commonly occurring in aging can be indexed by biomarkers. We used cluster analysis to identify sub-groups of individuals with different biomarker profiles. CSF from cognitively unimpaired individuals (n=99, 64-93 years) was analyzed for concentrations of Aβ42, phosphorylated tau (P-tau), and total tau (T-tau), and biomarkers for neuroinflammation (YKL-40), neuronal (FABP3) and axonal damage (NFL). Hippocampal volume and memory were assessed across multiple follow-up examin...
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#1Erin Bennett (GW: George Washington University)
#2Kan Z. Gianattasio (GW: George Washington University)H-Index: 1
Last. Melinda C. Power (GW: George Washington University)H-Index: 20
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Abstract Elevated LDL cholesterol (LDL-c) and total cholesterol in midlife and decline in total cholesterol from mid- to late-life are associated with incident dementia. Whether brain amyloid deposition mediates this relationship is unclear. We explored the association between midlife blood lipid levels and mid- to late-life change in lipid levels with brain amyloid deposition assessed using flobetapir PET scans in a biracial sample of 325 non-demented participants of the Atherosclerosis Risk in...
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Last. Hong Qing (BIT: Beijing Institute of Technology)H-Index: 15
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Abstract Neuroinflammatory responses mediated by microglia, the resident immune cells of the central nervous system, have long been a subject of study in the field of Alzheimer's disease (AD). Microglia express a wide range of receptors that act as molecular sensors, through which they can fulfill their various functions. In this review, we first analyzed the changes in the expression levels of microglial membrane receptors SR-A, TREM2, CD36, CD33, and CR3 in aging and AD and described the diffe...
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#1Xenia Sawkulycz (MMU: Manchester Metropolitan University)
#2Steven Bradburn (MMU: Manchester Metropolitan University)H-Index: 7
Last. Chris Murgatroyd (MMU: Manchester Metropolitan University)H-Index: 20
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Abstract The cytokine interleukin 6 (IL-6), has been linked to the pathogenesis of Alzheimer’s disease (AD). This is the first study to investigate the genetic and epigenetic interactions in the control of IL-6 in human brain and its relation to AD neuropathology in prefrontal cortex tissues from AD and controls genotyped for the SNP -174 C/G rs1800795, a polymorphic CpG in which the G allele creates a CpG site. Within CC homozygotes there were significantly higher brain levels of IL-6 protein c...
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#1Phoebe WalshH-Index: 1
#2Carole H. Sudre (UCL: University College London)H-Index: 9
Last. Adni investigatorsH-Index: 1
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This study investigated the relationship between white matter hyperintensities (WMH) and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers. Subjects included 180 controls, 107 individuals with a significant memory concern (SMC), 320 individuals with early mild cognitive impairment (EMCI), 171 individuals with late mild cognitive impairment (LMCI) and 151 individuals with AD, with 3T MRI and CSF Aβ1-42, total tau (t-tau) and phosphorylated tau (p-tau) data. Multiple linear regression ...
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#1Maria-Eleni Dounavi (University of Cambridge)
#2Elijah Mak (University of Cambridge)H-Index: 17
Last. John T. O'Brien (University of Cambridge)H-Index: 101
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Abstract The hippocampus is one of the first regions to demonstrate atrophy during the prodromal stage of Alzheimer’s disease. Volumetric analysis of its individual subfields could provide biomarkers with higher sensitivity than whole hippocampal volume during an earlier disease stage. We quantified the hippocampal subfields volume in a large cohort comprising healthy participants (aged 40-59) with dementia family history (FH) and controls (without FH), examined at two time-points across two yea...
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#1Sydney Lamerand (NU: Northwestern University)
#2Ryan Shahidehpour (NU: Northwestern University)H-Index: 1
Last. Changiz Geula (NU: Northwestern University)H-Index: 39
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Abstract Certain neuronal populations, including the cholinergic neurons of the basal forebrain (BFCN) and the noradrenergic neurons of the locus coeruleus (LC), are selectively vulnerable to pathology and loss early in the course of aging and Alzheimer’s disease (AD). We have shown that BFCN in the human brain show a substantial loss of the calcium binding protein, calbindin-D28K (CB), over the course of normal aging, which is associated with formation of neurofibrillary tangles and loss of BFC...
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Endocrinology
Psychology
Disease
Alzheimer's disease
Diabetes mellitus
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