David A. Bennett
Rush University Medical Center
PsychologyCognitionDementiaAlzheimer's diseaseMedicine
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Publications 1661
#1Hui Wang (HAU: Huazhong Agricultural University)
#2Jingyun Yang (Rush University Medical Center)H-Index: 24
Last. Hong-Yu Zhang (HAU: Huazhong Agricultural University)
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Abstract Genome-wide association studies have identified many loci associated with Alzheimer’s dementia. However, these variants only explain part of the heritability of Alzheimer’s disease (AD). As genetic epistasis can be a major contributor to the “missing heritability” of AD, we conducted genome-wide epistasis screening for AD pathologies in two independent cohorts. First, we performed a genome-wide epistasis study of AD-related brain pathologies (Nmax = 1,318) in ROS/MAP. Candidate interact...
Last. Richard MayeuxH-Index: 130
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Objective Synonymous variants can lead to disease; nevertheless, the majority of sequencing studies conducted in Alzheimer disease (AD) only assessed coding variation. Methods To detect synonymous variants modulating AD risk, we conducted a whole-genome sequencing study on 67 Caribbean Hispanic (CH) families multiply affected by AD. Identified disease-associated variants were further assessed in an independent cohort of CHs, expression quantitative trait locus (eQTL) data, brain autopsy data, an...
1 CitationsSource
#1Richard Sherva (BU: Boston University)H-Index: 28
#2Alden L. Gross (Johns Hopkins University)H-Index: 25
Last. Carlos CruchagaH-Index: 51
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#1Aliza P. Wingo (Emory University)H-Index: 17
#2Wen Fan (Emory University)
Last. Juan C. Troncoso (Johns Hopkins University)H-Index: 81
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#1Neha S. RaghavanH-Index: 2
#2Logan Dumitrescu (VUMC: Vanderbilt University Medical Center)H-Index: 5
Last. Corinne D. Engelman (UW: University of Wisconsin-Madison)H-Index: 22
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Importance Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis of the preclinical phase of the disease. Objective To examine the underlying genetic basis for brain amyloidosis in the preclinical phase of Alzheimer disease. Design, Setting, and Participants In the first stage of this genetic association study, a meta-analysis was conducted using genetic and imaging data acquired from 6 multic...
#1Zoe Arvanitakis (Rush University Medical Center)H-Index: 34
#2Hoau-Yan Wang (CUNY: City University of New York)H-Index: 32
Last. Steven E. Arnold (Harvard University)H-Index: 89
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OBJECTIVE To examine associations of molecular markers of brain insulin signaling with Alzheimer's disease (AD) and cognition, among older persons with or without diabetes. METHODS This clinical-pathologic study was derived from a community-based cohort study, the Religious Orders Study. We studied 150 individuals (mean age-at-death =87 years, 48% women): 75 with and 75 without diabetes (matched by sex on age-at-death and education). Using ELISA, immunohistochemistry and ex vivo stimulation of b...
#1Klodian DhanaH-Index: 1
#2Denis A. EvansH-Index: 99
Last. Martha Clare MorrisH-Index: 52
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Objective To quantify the impact of a healthy lifestyle on the risk of Alzheimer dementia. Methods Using data from the Chicago Health and Aging Project (CHAP; n = 1,845) and the Rush Memory and Aging Project (MAP; n = 920), we defined a healthy lifestyle score on the basis of nonsmoking, ≥150 min/wk moderate/vigorous-intensity physical activity, light to moderate alcohol consumption, high-quality Mediterranean-DASH Diet Intervention for Neurodegenerative Delay diet (upper 40%), and engagement in...
#1Crystal M. Glover (Rush Medical College)H-Index: 7
#2Lei Yu (Rush Medical College)H-Index: 73
Last. Patricia A. Boyle (Rush Medical College)H-Index: 58
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Abstract Objectives The purpose of this study was to test the hypothesis that late life cognitive activity is associated with decision making in older adults and to examine whether this association varies by level of cognitive function. Design This study employed a cross-sectional design. Setting All data were collected in participants’ community-based residences. Participants Participants were 1084 older adults (mean age=81.05 years, SD=7.53) without dementia (median MMSE score=29, IQR=27.86 – ...