Abstract 836: From tobacco smoking to mutation signature: The role of epigenetic changes in human cancers

Tobacco smoking is associated with a unique mutation signature in the human cancer genome. It is unclear whether tobacco smoking alters DNA methylations and gene expressions affect smoking-related mutation signature. In this study, we evaluated the smoking-related DNA methylation sites reported from five previous studies using peripheral blood cells to identify possible target genes. Using the mediation analysis approach, we evaluated whether...