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Cancer Research
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#1Man-Li Luo (SYSU: Sun Yat-sen University)
#2Fang Zheng (Memorial Hospital of South Bend)
Last. Xiao Zhen Zhou (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 36
view all 14 authors...
PARP inhibitor monotherapies effectively treat breast, ovary, prostate, and pancreatic cancer patients with BRCA1 mutations, but not the more frequent BRCA-wildtype cancers. Searching for strategies that would extend the use of PARP inhibitors to BRCA1-proficient tumors, we report here that the stability of BRCA1 protein following ionizing radiation (IR) is maintained by post-phosphorylational prolyl-isomerization adjacent to Ser1191 of BRCA1, which is catalyzed by prolyl-isomerase Pin1. Extinct...
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#1Jaebeom Cho (SNU: Seoul National University)H-Index: 4
#2Hyo-Jong Lee (Inje University)H-Index: 12
Last. Hyun-Ji Jang (SNU: Seoul National University)H-Index: 3
view all 15 authors...
Quiescent cancer cells are believed to cause cancer progression after chemotherapy through unknown mechanisms. We show here that human non-small-cell lung cancer (NSCLC) cell line-derived, quiescent-like, slow-cycling cancer cells (SCC) and residual patient-derived xenograft (PDX) tumors after chemotherapy experience activating transcription factor 6 (ATF6)-mediated upregulation of various cytokines, which acts in a paracrine manner to recruit fibroblasts. Cancer-associated fibroblasts (CAF) und...
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#1Casimiro Gerarduzzi (UdeM: Université de Montréal)H-Index: 5
#2Ursula Hartmann (University of Cologne)H-Index: 13
Last. Elliot A. Drobetsky (UdeM: Université de Montréal)H-Index: 15
view all 4 authors...
The extracellular matrix (ECM) surrounding cells is indispensable for regulating their behavior. The dynamics of ECM signaling are tightly controlled throughout growth and development. During tissue remodeling, matricellular proteins (MCPs) are secreted into the ECM. These factors do not serve classical structural roles, but rather regulate matrix proteins and cell-matrix interactions to influence normal cellular functions. In the tumor microenvironment, it is becoming increasingly clear that ab...
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#1Yi Zhao (Hanyang University)
#2Neha Kaushik (Hanyang University)H-Index: 15
Last. Su-Jae Lee (Hanyang University)H-Index: 1
view all 9 authors...
Stemness and epithelial-mesenchymal transition (EMT) are two fundamental characteristics of metastasis that are controlled by diverse regulatory factors, including transcription factors. Compared with other subtypes of breast cancer, basal-type or triple-negative breast cancer (TNBC) have high frequencies of tumor relapse. However, the role of alpha-globin transcription factor CP2 (TFCP2) has not been reported as an oncogenic driver in those breast cancers. Here we show that TFCP2 is a potent fa...
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#1Yi HuH-Index: 1
#2Huimin Liu (Qingdao University)
Last. Wenjun Li (Qingdao University)
view all 22 authors...
Multiple myeloma (MM) is an incurable refractory hematological malignancy arising from plasma cells in the bone marrow. Here we investigated miR-26a function in MM and tested single-wall carbon nanotube delivery of miR-26a in vitro and in vivo. miR-26a was downregulated in patient MM cells compared with plasma cells from healthy donors. miR-26a overexpression inhibited proliferation and migration and induced apoptosis in MM cell lines. To identify the targets of miR-26a, RPMI8226-V-miR-26-GFP an...
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#1Koen D. Flach (NKI-AVL: Netherlands Cancer Institute)H-Index: 6
#2Manikandan Periyasamy (Imperial College London)H-Index: 15
Last. David M. Wilson (University of Hasselt)H-Index: 49
view all 22 authors...
Estrogen receptor α (ERα) is a key transcriptional regulator in the majority of breast cancers. ERα-positive patients are frequently treated with tamoxifen, but resistance is common. In this study, we refined a previously identified 111-gene outcome prediction-classifier, revealing FEN1 as the strongest determining factor in ERα-positive patient prognostication. FEN1 levels were predictive of outcome in tamoxifen-treated patients, and FEN1played a causal role in ERα-driven cell growth. FEN1 impa...
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#1Dezhong Lv (HMU: Harbin Medical University)
#2Kang Xu (HMU: Harbin Medical University)H-Index: 1
Last. Xia Li (HMU: Harbin Medical University)H-Index: 36
view all 10 authors...
Long noncoding RNAs (LncRNA) play important roles in maintaining morphology and function of tissues, and their regulatory effectiveness is closely associated with spatial expression. To provide a comprehensive spatial atlas of expression for lncRNA, we propose LncSpA (http://bio-bigdata.hrbmu.edu.cn/LncSpA) to explore tissue-elevated (TE) lncRNA across human normal and adult and pediatric cancer tissues. In total, 71,131 and 12,007 TE lncRNA and 634 clinical-related TE lncRNA were identified acr...
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#1Jacqueline H Starrett (Yale University)H-Index: 1
#2Alexis A Guernet (AstraZeneca)
Last. Kumar Dilip Ashtekar (Yale University)
view all 24 authors...
Osimertinib, a mutant-specific third generation EGFR TKI, is emerging as the preferred first-line therapy for EGFR mutant lung cancer, yet resistance inevitably develops in patients. We modeled acquired resistance to osimertinib in transgenic mouse models of EGFR L858R-induced lung adenocarcinoma and found that it is mediated largely through secondary mutations in EGFR - either C797S or L718V/Q. Analysis of circulating free DNA data from patients revealed that L718Q/V mutations almost always occ...
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Introduction: Quality of life and functionality of critically ill cancer patients are significantly affected after ICU admission, with changes due to immobility, hemodynamic instability, muscular atrophy, cognitive deficits, psychological difficulties, decreased cardiovascular functional capacity, neurological deleterious effects on the respiratory system. The physiotherapeutic intervention is effective in preventing and reducing the deleterious dysfunctions of immobility, as well as improving t...
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#1Balazs AcsH-Index: 3
Last. Jane BayaniH-Index: 35
view all 50 authors...
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Cancer
Molecular biology
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