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Cancer Research
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#1Guo ChenH-Index: 12
#2Dongkyoo ParkH-Index: 8
Last.Xingming DengH-Index: 34
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#1Robert S. Oakes (UM: University of Michigan)H-Index: 8
#2Grace G. Bushnell (UM: University of Michigan)H-Index: 6
Last.Lonnie D. Shea (UM: University of Michigan)H-Index: 61
view all 14 authors...
Monitoring metastatic events in distal tissues is challenged by their sporadic occurrence in obscure and inaccessible locations within these vital organs. A synthetic biomaterial scaffold can function as a synthetic metastatic niche to reveal the nature of these distal sites. These implanted scaffolds promote tissue ingrowth, which upon cancer initiation is transformed into a metastatic niche that captures aggressive circulating tumor cells. We hypothesized that immune cell phenotypes at synthet...
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#1Matthias KlingerH-Index: 15
#2Gerhard ZugmaierH-Index: 33
Last.Peter KuferH-Index: 45
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#1Ernest Hawk (University of Texas MD Anderson Cancer Center)H-Index: 13
#2Karen Colbert Maresso (University of Texas MD Anderson Cancer Center)H-Index: 3
E-cigarettes have the ability to deliver nicotine in a manner that is similar to, and - theoretically - safer than, combusted tobacco. However, these devices are extremely heterogeneous and regulation has struggled to keep up with their rapid evolution. A compilation of early data suggest that e-cigarettes may contain numerous toxic substances, including known carcinogens. However, there are few data available on the short- and long- term health effects of e-cigarettes, including any potential e...
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#1Jean Chiou (AS: Academia Sinica)H-Index: 5
#2Yu-Chan Chang (AS: Academia Sinica)H-Index: 3
Last.Michael Hsiao (AS: Academia Sinica)H-Index: 42
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Follistatin-like protein 1 (FSTL1) plays a critical role in lung organogenesis, but is downregulated during lung cancer development and progression. The prognostic significance and functional consequences of FSTL1 downregulation in lung cancer are unclear. Here, reduced levels of FSTL1 were detected in various tumors compared to normal tissues and were associated with poor clinical outcome in patients with non-small cell lung cancer, particularly those with lung adenocarcinoma. FSTL1 expression ...
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Background: Breast cancer is the commonest form of cancer in females which may be curable if detected early. Breast ultrasound (US) is a non invasive, primary screening tool which can evaluate breast tumors in women even with dense breast. By adding color Doppler signal with B-mode US namely Duplex ultrasound better characterization of breast tumors is possible especially for the indeterminate tumors (BIRADS category 3 and 4) on B-Mode US. Objective: The purpose of this study is to assess the ef...
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#1Joseph J. Chen (University of California, Berkeley)H-Index: 5
#2Badriprasad Ananthanarayanan (University of California, Berkeley)H-Index: 9
Last.Sanjay Kumar (University of California, Berkeley)H-Index: 60
view all 7 authors...
The aggressive brain tumor glioblastoma¬ (GBM) is characterized by rapid cellular infiltration of brain tissue, raising the possibility that disease progression could potentially be slowed by disrupting the machinery of cell migration. The LIM kinase isoforms LIMK1 and LIMK2 (LIMK1/2) play important roles in cell polarization, migration, and invasion and are markedly upregulated in GBM and many other infiltrative cancers. Yet, it remains unclear whether LIMK suppression could serve as a viable b...
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