Wanqing Wen
Vanderbilt University Medical Center
CancerOdds ratioPopulationBreast cancerMedicine
What is this?
Publications 199
#1Jae Jeong Yang (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Danxia Yu (VUMC: Vanderbilt University Medical Center)H-Index: 16
Last. Jiang He (Tulane University)H-Index: 103
view all 42 authors...
BACKGROUND Little is known about the health harms associated with low-intensity smoking in Asians who, on average, smoke fewer cigarettes and start smoking at a later age than their Western counterparts. METHODS In this pooled analysis of 738 013 Asians from 16 prospective cohorts, we quantified the associations of low-intensity ( twofold risk of lung cancer mortality. Furthermore, current smokers who started smoking after age 35 and smoked <5 cigarettes/day had significantly elevated risks of a...
#1Heming Wang (Brigham and Women's Hospital)H-Index: 10
#2Raymond Noordam (LUMC: Leiden University Medical Center)H-Index: 14
Last. Hugues Aschard (Harvard University)H-Index: 21
view all 125 authors...
Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups using 1 degree of freedom (1df) interaction a...
#1L. de las Fuentes (WashU: Washington University in St. Louis)H-Index: 1
#1Lisa de las Fuentes (WashU: Washington University in St. Louis)H-Index: 23
Last. Alisa K. Manning (Harvard University)H-Index: 39
view all 222 authors...
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects....
1 CitationsSource
#1Chenjie Zeng (Vandy: Vanderbilt University)H-Index: 8
#2Xingyi Guo (Vandy: Vanderbilt University)H-Index: 24
Last. Wei Zheng (Vandy: Vanderbilt University)H-Index: 105
view all 9 authors...
PURPOSE: Limited studies have been conducted to evaluate pathogenetic mutations in breast cancer predisposition genes among Chinese women. To fully characterize germline mutations of these genes in this population, we used the whole-exome sequencing data in a population-based case-control study conducted in Shanghai, China. METHODS: We evaluated exonic, splicing, and copy number variants in 11 established and 14 candidate breast cancer predisposition genes in 831 invasive breast cancer cases and...
#1Xingyi Guo (Vandy: Vanderbilt University)H-Index: 24
#2Jirong Long (Vandy: Vanderbilt University)H-Index: 51
Last. Wei Zheng (Vandy: Vanderbilt University)H-Index: 105
view all 10 authors...
The missing heritability of breast cancer could be partially attributed to rare variants (MAF 4,500 East Asian women from the genome Aggregation database (gnomAD), providing additional support to our findings. Our study revealed a potential novel gene and multiple disruptive variants of BRCA2 for breast cancer risk, which may identify high-risk women in Chinese populations.
1 CitationsSource
#1Guochong Jia (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Yingchang Lu (VUMC: Vanderbilt University Medical Center)H-Index: 2
Last. Wei Zheng (VUMC: Vanderbilt University Medical Center)H-Index: 105
view all 10 authors...
1 CitationsSource
#1Yumie Takata (Vandy: Vanderbilt University)H-Index: 9
#2Xiao-Ou Shu (Vandy: Vanderbilt University)H-Index: 100
Last. Qiuyin Cai (Vandy: Vanderbilt University)H-Index: 66
view all 9 authors...
Purpose We prospectively examined associations of lung cancer risk with food intake of B vitamins involved in one-carbon metabolism and the use of folic acid-containing supplements among a low-income population of black and white adults in the Southeastern US.
1 CitationsSource
#1Yingchang Lu (VUMC: Vanderbilt University Medical Center)
#1Yingchang Lu (Vandy: Vanderbilt University)H-Index: 38
Last. Wei Zheng (VUMC: Vanderbilt University Medical Center)H-Index: 105
view all 52 authors...
Background: Risk variants identified so far for colorectal cancer (CRC) explain only a small proportion of familial risk of this cancer, particularly in Asians. Methods: We performed a genome-wide association study (GWAS) of CRC in East Asians including 23,572 CRC cases and 48,700 controls. To identify novel risk loci, we selected sixty promising risk variants for replication using data from 58,131 CRC cases and 67,347 controls of European descent. To identify additional risk variants in known C...
#1Guochong Jia (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Xiao-Ou Shu (VUMC: Vanderbilt University Medical Center)H-Index: 100
Last. Wei Zheng (VUMC: Vanderbilt University Medical Center)H-Index: 105
view all 10 authors...
Importance The association of weight gain from early to middle adulthood with disease risk has not been adequately studied. Objective To investigate the association of adult weight gain with major health outcomes in a Chinese population with low body weight in early adulthood. Design, Setting, and Participants This population-based cohort study assessed data from 48 377 women and 35 989 men aged 40 to 59 years at recruitment in 2 prospective cohort studies in China. The Shanghai Women’s Health S...
#1Raymond Noordam (LUMC: Leiden University Medical Center)H-Index: 14
#2Maxime M. Bos (LUMC: Leiden University Medical Center)H-Index: 1
Last. Susan Redline (Brigham and Women's Hospital)H-Index: 111
view all 148 authors...
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint ana...
4 CitationsSource