Wanqing Wen
Vanderbilt University
Publications 186
#1Tuomas O. Kilpelaeinen (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 31
#2Amy R. Bentley (NIH: National Institutes of Health)H-Index: 15
Last.Ioanna Ntalla (QMUL: Queen Mary University of London)H-Index: 27
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Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
#1Zhishan Chen (VUMC: Vanderbilt University Medical Center)
#2Wanqing Wen (VUMC: Vanderbilt University Medical Center)H-Index: 51
Last.Xingyi Guo (VUMC: Vanderbilt University Medical Center)H-Index: 23
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Although APOBEC-mutational signature is found in tumor tissues of multiple cancers, how a common germline APOBEC3A/B deletion affects the mutational signature remains unclear. Using data from 10 cancer types generated as part of TCGA, we performed integrative genomic and association analyses to assess inter-relationship of expressions for isoforms APOBEC3A and APOBEC3B, APOBEC-mutational signature, germline APOBEC3A/B deletions, neoantigen loads, and tumor infiltration lymphocytes (TILs). We fou...
#1Zhishan Chen (Vandy: Vanderbilt University)
#2Wanqing Wen (Vandy: Vanderbilt University)H-Index: 51
Last.Qiuyin Cai (Vandy: Vanderbilt University)H-Index: 64
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Genome-wide association studies (GWASs) have identified hundreds of genetic risk variants for human cancers. However, target genes for the majority of risk loci remain largely unexplored. It is also unclear whether GWAS risk-loci-associated genes contribute to mutational signatures and tumor mutational burden (TMB) in cancer tissues. We systematically conducted cis-expression quantitative trait loci (cis-eQTL) analyses for 294 GWAS-identified variants for six major types of cancer—colorectal, lu...
#1Yun Ju Sung (WashU: Washington University in St. Louis)H-Index: 17
#2Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
Last.Helen R. Warren (QMUL: Queen Mary University of London)H-Index: 19
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#1Yong Cui (VUMC: Vanderbilt University Medical Center)H-Index: 15
#2Wanqing Wen (VUMC: Vanderbilt University Medical Center)H-Index: 51
Last.Mingrong You (VUMC: Vanderbilt University Medical Center)
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#1Xingyi Guo (VUMC: Vanderbilt University Medical Center)H-Index: 23
#2Weiqiang Lin (ZJU: Zhejiang University)H-Index: 1
Last.Qiuyin Cai (Vandy: Vanderbilt University)H-Index: 64
view all 14 authors...
Background: Pathogenic variants in susceptibility genes lead to increased breast cancer risk. Methods: To identify coding variants associated with breast cancer risk, we conducted whole exome sequencing in genomic DNA samples from 831 breast cancer cases and 839 controls of Chinese women. We also genotyped samples including 4,580 breast cancer cases and 6,695 controls using whole exome-chip arrays. We further performed a replication study using a Multi-Ethnic Global Array (MEGA) in samples from ...
#1Wanqing Wen (Vandy: Vanderbilt University)H-Index: 51
#2David G. Schlundt (Vandy: Vanderbilt University)H-Index: 39
Last.Wei Zheng (Vandy: Vanderbilt University)H-Index: 20
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Objective This study aimed to evaluate the impacts of various forms of religious involvement, beyond individual socioeconomic status, lifestyle factors, emotional well-being and social support, on all-cause and cause-specific mortality in socioeconomic disadvantaged neighbourhoods. Design This is a prospective cohort study conducted from 2002 through 2015. Settings This study included underserved populations in the Southeastern USA. Participants A total of nearly 85 000 participants, primarily l...