Zhishan Chen
Vanderbilt University Medical Center
Publications 2
#1Zhishan Chen (VUMC: Vanderbilt University Medical Center)
#2Wanqing Wen (VUMC: Vanderbilt University Medical Center)H-Index: 52
Last.Xingyi Guo (VUMC: Vanderbilt University Medical Center)H-Index: 24
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Although APOBEC-mutational signature is found in tumor tissues of multiple cancers, how a common germline APOBEC3A/B deletion affects the mutational signature remains unclear. Using data from 10 cancer types generated as part of TCGA, we performed integrative genomic and association analyses to assess inter-relationship of expressions for isoforms APOBEC3A and APOBEC3B, APOBEC-mutational signature, germline APOBEC3A/B deletions, neoantigen loads, and tumor infiltration lymphocytes (TILs). We fou...
#1Xingyi Guo (VUMC: Vanderbilt University Medical Center)H-Index: 24
#2Weiqiang Lin (ZJU: Zhejiang University)H-Index: 1
Last.Wei Zheng (VUMC: Vanderbilt University Medical Center)H-Index: 105
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Background: Pathogenic variants in susceptibility genes lead to increased breast cancer risk. Methods: To identify coding variants associated with breast cancer risk, we conducted whole-exome sequencing in genomic DNA samples from 831 breast cancer cases and 839 controls of Chinese women. We also genotyped samples, including 4,580 breast cancer cases and 6,695 controls, using whole exome-chip arrays. We further performed a replication study using a Multi-Ethnic Global Array in samples from 1,793...