Changes in Resting-State Functional Connectivity of the Hippocampus Following Cognitive Effort Predict Memory Decline at Older Age—A Longitudinal fMRI Study

Identifying older adults at risk for memory impairment is an important goal for initiating early treatment and prevention strategies. We examined the resting-state functional connectivity (RSFC) of older and younger adults before and after cognitive effort as a marker for subsequent memory decline, focusing on the connectivity between the left anterior hippocampus (laHC) and the posterior hippocampi (pHC). Results showed that for younger adults,...