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Frontiers in Aging Neuroscience
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Mitochondria are associated with various radiation responses, including mitophagy, adaptive responses, genomic instability, the bystander effect, and apoptosis. Mitochondria play a key role in maintaining cellular homeostasis during stress responses, and mitochondrial dysfunction contributes to aging, carcinogenesis and neurologic diseases. In this study we have investigated the mitochondrial degeneration and autophagy in the hippocampal region of brains from mice administered with BBT-059, a lo...
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INTRODUCTION: Hearing and vision loss are highly prevalent in older adults and thus very frequently occur in conjunction with cognitive impairments. Studies have shown that hearing impairment is associated with a higher risk of incident dementia. However, evidence concerning the association between vision loss and incident dementia as well as the co-occurrence of vision and hearing loss and incident dementia has been inconclusive. OBJECTIVES: To assess the association between i) either hearing o...
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Microglia and astrocytes can quench metal toxicity to maintain tissue homeostasis, but with age, increasing glial dystrophy alongside metal dyshomeostasis may predispose the aged brain to acquire neurodegenerative diseases. The aim of the present study was to investigate age-related changes in brain metal deposition along with glial distribution in normal C57Bl/6J mice aged 2-, 6-, 19- and 27-months (n=4/age). Using synchrotron-based X-ray fluorescence elemental mapping, we demonstrated age-rela...
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Physical exercise performed regularly is known to improve health and to reduce the risk of age-related diseases. Furthermore, there is some evidence of cognitive improvement in physically active middle-aged and older adults. We hypothesized that long-term physically active middle-aged men may have developed brain resilience that can be detected with the analysis of peripheral blood markers. We aimed to analyze the activation of pathways potentially modulated by physical activity in a cohort of h...
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Chronic pain disproportionately affects older adults, severely impacting quality of life and independent living, with musculoskeletal pain most prevalent. Chronic musculoskeletal pain is associated with specific structural alterations in the brain and interindividual variability in brain structure is likely an important contributor to susceptibility for the development of chronic pain. However, understanding of age-related structural changes in the brain and their associations with chronic muscu...
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Alzheimer’s disease (AD), the most common tauopathy, is age dependent progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in onset and progression of AD. Despite mutations in familial AD, conundrums of risk factors have been implicated in sporadic AD, of which the onset is unknown. In AD, there is a sequential and hierarchical spread of tau pathology to other brain areas. Studies have strived to understand the factors that influence this charac...
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Post-stroke systemic injections of insulin-like growth factor 1 (IGF-1) exert neuroprotective effects in rats. In the current study, we aimed to test the efficacy of IGF-1 neuroprotection in aged rats (24-25 months old) and to compare the results with adult rats (6-7 months old). Furthermore, we addressed putative differences in microglial responses to IGF-1 in adult and aged rats. Rats were subjected to ischemic stroke while they were conscious by infusing endothelin-1 (Et-1) through a guide ca...
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Developmental psychology
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