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Frontiers in Aging Neuroscience
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#2Franziska Kirsch (MPG: Max Planck Society)
Last.Bernhard Sehm (MPG: Max Planck Society)H-Index: 14
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Background: Proprioception is a prerequisite for successful motor control but declines throughout the lifespan. Brain stimulation techniques such as anodal transcranial direct current stimulation (a-tDCS) are capable of enhancing sensorimotor performance across different tasks and age groups. Despite such growing evidence for a restorative potential of tDCS, its impact on proprioceptive accuracy has not been studied in detail yet. Objective: This study investigated online effects of a-tDCS over ...
#1Yanpei Wang (BNU: Beijing Normal University)H-Index: 1
#2Qinfang Xu (Nanjing Normal University)
Last.Chenyi Zuo (Anhui Normal University)H-Index: 1
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Purpose: In an increasingly ageing society, it is of great importance to consider trajectories of subcortical volumes at different ages for understanding biological markers of ageing. Thus, we investigated sex, age and their interactions on subcortical volumes, including the basal ganglia, thalamus, hippocampus and amygdala. Methods: We analysed the adult lifespan trajectory of subcortical volumes and asymmetries in 563 healthy subjects aged from 19 to 86 using magnetic resonance imaging (MRI) d...
Processing of amyloid beta precursor protein (APP) into amyloid-beta peptide (A) by -secretase and -secretase complex is at the heart of the pathogenesis of Alzheimer’s disease (AD). Targeting this proteolytic pathway effectively reduces/prevents pathology and cognitive decline in preclinical experimental models of the disease, but therapeutic strategies based on secretase activity modifying drugs have so far failed in clinical trials. Although this may raise some doubts on the relevance of ...
#1Sydney K. Vaughan (VT: Virginia Tech)H-Index: 3
#2Natalia M. Sutherland (VT: Virginia Tech)H-Index: 1
Last.Gregorio Valdez (VT: Virginia Tech)H-Index: 16
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In addition to driving contraction of skeletal muscles, acetylcholine (ACh) acts as an anti-synaptogenic agent at neuromuscular junctions (NMJs). In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular acetylcholine transporter (VKDHet), which present with approxima...
#1E. D. de Bruin (KI: Karolinska Institutet)H-Index: 36
#2Nadine Patt (ETH Zurich)
Last.Federico Gennaro (ETH Zurich)H-Index: 1
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Gait training might be of particular importance to reduce fall risk in older adults. In the present study we explore the hypothesis that video game-based training will increase tibialis anterior muscle EMG-EMG coherence and relates to functional measures of lower limb control. We focus on video game-based training, which necessitates the subject’s ability to lift the toes and to place the feet on different target zones as a requirement to successfully play the game. We hypothesize that this type...
Alzheimer’s disease (AD) is the most common form of dementia and affects over 45 million people worldwide. Both type-2-diabetes (T2D), a metabolic condition associated with aging, and disrupted sleep are implicated in the pathogenesis of AD, but how sleep and metabolism interact to affect AD progression remains unclear. In the healthy brain, sleep/wake cycles are a well-coordinated interaction between metabolic and neuronal activity, but when disrupted, are associated with a myriad of health-rel...
#1Qinying Ma (Hebei Medical University)H-Index: 3
#2Yuan Geng (Hebei Medical University)H-Index: 7
Last.Ming-Wei Wang (Hebei Medical University)H-Index: 13
view all 8 authors...
Normal aging is accompanied by hippocampus-dependent cognitive impairment and act as a risk factor of Alzheimer’s disease (AD). The study aims to investigate the effect of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on hippocampus-dependent learning and memory in aged mice and to explore the underlying mechanisms. Forty-five male Kunming mice (15-month-old) were randomly divided into 3 aged groups: aged sham, 5Hz rTMS and 25Hz rTMS group. Two sessions of 5Hz or 25Hz rTM...
#1Robin Maximilian Himmelmeier (Tohoku University)
#2Rui Nouchi (Tohoku University)H-Index: 22
Last.Ryuta Kawashima (Tohoku University)H-Index: 60
view all 6 authors...
Background Elderly people are affected by processes leading to decline in various aspects of daily living that impair their quality of life. Regarding neurological aspects, executive functions have been shown to be valuable for daily life and to slow decline during aging. Most intervention studies intended to improve cognitive functions during aging specifically address long-term destructive processes and countermeasures. However, to an increasing degree, studies also investigate the acute benef...
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