S3. Visualizing the Cholinergic System in Health and Disease

In the central nervous system, cholinergic neurons of the basal forebrain (BFCNs) exert tight, context specific control over cortical processes. The enormous reach of their projections makes cholinergic axonal arbors difficult to maintain and vulnerable to loss. Post-mortem studies have demonstrated that decreases in cholinergic markers accompany decline in cognitive function. As such, we asked what role the cholinergic system plays in cognition...