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Biological Psychiatry
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#1Sandra Sanchez-Roige (UCSD: University of California, San Diego)H-Index: 18
#2Abraham A. Palmer (UCSD: University of California, San Diego)H-Index: 39
Last. Toni-Kim Clarke (Edin.: University of Edinburgh)H-Index: 26
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Abstract Alcohol use disorders (AUD) are defined by several symptom criteria, which can be further dissected at the genetic level. Over the past several years, our understanding of the genetic factors influencing alcohol use and abuse has progressed tremendously; hundreds of loci have now been implicated in different aspects of alcohol use. Previously known associations with alcohol metabolizing enzymes (ADH1B, ALDH2) have been definitively replicated. Additionally, novel associations with loci ...
3 CitationsSource
#1Angela K. Yang (McGill University)H-Index: 1
#2Jesse A. Mendoza (McGill University)H-Index: 1
Last. Jonathan P. Britt (McGill University)H-Index: 12
view all 5 authors...
ABSTRACT BACKGROUND Insight into the neural basis of hedonic processing has come from studies of food palatability in rodents. Pharmacological manipulations of the nucleus accumbens shell (NAcSh) have repeatedly been demonstrated to increase hedonic taste reactivity, yet the contribution of specific NAcSh circuit components is unknown. METHODS Bidirectional optogenetic manipulations are targeted to the principal NAcSh projection neurons and afferent pathways of mice during free feeding assays. N...
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#1Andrew F. Scheyer (AMU: Aix-Marseille University)H-Index: 4
#2Milene Borsoi (AMU: Aix-Marseille University)H-Index: 1
Last. Olivier J. Manzoni (AMU: Aix-Marseille University)H-Index: 5
view all 7 authors...
Abstract Background Cannabis usage is increasing with its widespread legalization. Cannabis use by mothers during lactation transfers active cannabinoids to the developing offspring during this critical period and alters postnatal neurodevelopment. A key neurodevelopmental landmark is the excitatory to inhibitory GABA switch caused by reciprocal changes in expression ratios of the K+/Cl- transporters KCC2 and NKCC1. Methods Rat dams were treated with THC or a synthetic cannabinoid during the fir...
2 CitationsSource
#1Nathan D. Winters (Vandy: Vanderbilt University)H-Index: 1
#2Sachin PatelH-Index: 37
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#1David A.A. Baranger (WashU: Washington University in St. Louis)H-Index: 8
#2Catherine H. Demers (WashU: Washington University in St. Louis)H-Index: 7
Last. Ryan Bogdan (WashU: Washington University in St. Louis)H-Index: 17
view all 14 authors...
ABSTRACT Background Alcohol use has been reliably associated with smaller subcortical and cortical regional gray matter volumes (GMVs). Whether these associations reflect shared predisposing risk factors and/or causal consequences of alcohol use remains poorly understood. Methods Data came from 3 neuroimaging samples (total n=2,423), spanning childhood/adolescence to middle age, with prospective or family-based data. First, we identified replicable GMV correlates of alcohol use. Next, we used fa...
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#1Xiaowei Dou (Harvard University)H-Index: 9
#2Jerry Y. Lee (Harvard University)
Last. Michael E. Charness (BU: Boston University)H-Index: 36
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Abstract Background Ethanol causes developmental neurotoxicity partly by blocking adhesion mediated by the L1 neural cell adhesion molecule. This action of ethanol is antagonized by femtomolar concentrations of the neuropeptide NAPVSIPQ (NAP), an active fragment of activity dependent neuroprotective peptide (ADNP). How femtomolar concentrations of NAP antagonize millimolar concentrations of ethanol is unknown. L1 sensitivity to ethanol requires L1 association with ankyrin-G; therefore, we asked ...
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#1Edith V. Sullivan (Stanford University)H-Index: 89
#2Ty Brumback (Northern Kentucky University)H-Index: 14
Last. Adolf Pfefferbaum (Stanford University)H-Index: 98
view all 12 authors...
ABSTRACT Objective The cerebellum is a target of alcoholism-related brain damage in adults. Yet no study has prospectively tracked deviations from normal cerebellar growth trajectories in adolescents before and after initiating drinking. Method MRI tracked developmental volume trajectories of 10 cerebellar lobule and vermis tissue constituents in 548 no-to-low drinking youth age 12-21 years at induction into this five-site, National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCAN...
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#1Alexander Soutschek (LMU: Ludwig Maximilian University of Munich)H-Index: 8
#2Geraldine Gvozdanovic (UZH: University of Zurich)H-Index: 1
Last. Philippe N. Tobler (ETH Zurich)H-Index: 30
view all 10 authors...
Abstract BACKGROUND Activation of D1 receptors has been related to successful goal-directed behavior, but it remains unclear whether D1 receptor activation causally tips the balance of weighing costs and benefits in humans. Here, the impact of pharmacologically stimulated D1 receptors was tested on sensitivity to risk, delay, and effort costs in economic choice and asked whether D1 receptor stimulation would bias preferences toward options with increased costs in a cost-specific manner. METHODS ...
2 CitationsSource
#1Alejandro D. Meruelo (UCSD: University of California, San Diego)H-Index: 7
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