Biological Psychiatry
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#1Austin W. Blum (U of C: University of Chicago)H-Index: 3
#2David A. Ross (Yale University)H-Index: 12
#1Varun Warrier (University of Cambridge)H-Index: 10
#1Robert F. Krueger (UMN: University of Minnesota)H-Index: 97
#2Colin G. DeYoung (UMN: University of Minnesota)H-Index: 1
#1Aristotle N. Voineskos (U of T: University of Toronto)H-Index: 35
#2Grace R. Jacobs (CAMH: Centre for Addiction and Mental Health)
Last. Stephanie H. Ameis (U of T: University of Toronto)H-Index: 12
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Abstract Heterogeneity in symptom presentation, outcomes, and treatment response has long been a thorn in the side of researchers aiming to identify biological markers of schizophrenia or psychosis. However, there is increasing recognition that there may likely be no such general illness markers, consistent with the notion of a group of schizophrenia(s) that may have both shared and unique neurobiological pathways. Instead, strategies aiming to capitalize or leverage such heterogeneity may help ...
4 CitationsSource
#1Theodore D. Satterthwaite (UPenn: University of Pennsylvania)H-Index: 49
#2Eric Feczko (OHSU: Oregon Health & Science University)H-Index: 19
Last. Damien A. Fair (OHSU: Oregon Health & Science University)H-Index: 49
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#1Antonia N. Kaczkurkin (Vandy: Vanderbilt University)H-Index: 2
#2Tyler M. Moore (UPenn: University of Pennsylvania)H-Index: 26
Last. Theodore D. Satterthwaite (UPenn: University of Pennsylvania)H-Index: 49
view all 6 authors...
Abstract Psychiatric disorders show high rates of co-morbidity and non-specificity of presenting clinical symptoms, while at the same time demonstrating substantial heterogeneity within diagnostic categories. Notably, many of these psychiatric disorders first manifest in youth. Here we review progress and next steps in efforts to parse heterogeneity in psychiatric symptoms in youth by identifying abnormalities within neural circuits. To address this fundamental challenge in psychiatry, a number ...
3 CitationsSource
#1Sarah L. Karalunas (OHSU: Oregon Health & Science University)H-Index: 17
#2Joel T. Nigg (OHSU: Oregon Health & Science University)H-Index: 81
Abstract Few if any experts believe that existing psychiatric diagnostic categories included in the DSM/ICD are actually discrete disease entities. Attention-deficit/hyperactivity disorder (ADHD) is emblematic of the problems in the existing psychiatric classification system. ADHD symptoms reliably cluster into two correlated dimensions in factor analysis. However, children with ADHD vary considerably in their symptom profiles, symptom trajectories, clinical outcomes, and biological and psycholo...
3 CitationsSource
#1Seok-Jun Hong (MIND Institute)H-Index: 19
#2Joshua T. Vogelstein (Johns Hopkins University)H-Index: 29
Last. Adriana Di Martino (MIND Institute)H-Index: 46
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Abstract There is a general consensus that substantial heterogeneity underlies the neurobiology of autism spectrum disorder (ASD). As such, it has become increasingly clear that a dissection of variation at the molecular, cellular, and brain-network domains is a prerequisite for identifying biomarkers. Neuroimaging has been widely used to characterize atypical brain patterns in ASD, though findings have varied across studies. This is, at least in part, due to a failure to account for neurobiolog...
3 CitationsSource
#1Stephanie M. GromanH-Index: 16
#2Ansel T. Hillmer (Yale University)H-Index: 10
Last. Jane R. TaylorH-Index: 72
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Abstract Background Compulsive patterns of drug use are thought to be the consequence of drug-induced adaptations in the neural mechanisms that enable behavior to be flexible. Neuroimaging studies have found evidence of robust alterations in glutamate and dopamine receptors within brain regions that are known to be critical for decision-making processes in cocaine-dependent individuals, and these changes have been argued to be the consequence of persistent drug use. The causal relationships betw...
#1Rebecca G. Brenner (WashU: Washington University in St. Louis)
#2Christopher D. Smyser (WashU: Washington University in St. Louis)H-Index: 22
Last. Cynthia E. Rogers (WashU: Washington University in St. Louis)H-Index: 20
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Abstract Background The cingulum bundle (CB), specifically the dorsal anterior portion of the CB, plays an important role in psychiatric illnesses; however, its role during early development is unclear. This study investigated whether neonatal white matter microstructure in the CB and its subregions is associated with subsequent preterm behavioral phenotype symptoms (internalizing, inattention, and social deficits) in very preterm (VPT) children. Method Diffusion MRI data were obtained on a 3T s...
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