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Biological Psychiatry
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11.50
Papers
19827
Papers 19887
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#1Sonja de Zwarte (UU: Utrecht University)H-Index: 3
#2Rachel M. Brouwer (UU: Utrecht University)H-Index: 31
Last.Aurora Bonvino (University of Bari)H-Index: 2
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Background Schizophrenia and bipolar disorder share genetic liability and some structural brain abnormalities are common to both conditions. First-degree relatives of schizophrenia patients (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in bipolar disorder first-degree relatives (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared to controls. Methods Here, we meta-analyzed global a...
#1Jennifer A. BodkinH-Index: 14
#2Michael J. ColemanH-Index: 27
Last.Dost ÖngürH-Index: 44
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Abstract Background The increased mutational burden for rare structural genomic variants in schizophrenia and other neurodevelopmental disorders has so far not yielded therapies targeting the biological effects of specific mutations. We identified two carriers (mother and son) of a triplication of the gene encoding glycine decarboxylase, GLDC , presumably resulting in reduced availability of the N -methyl-D-aspartate receptor coagonists glycine and D-serine and N -methyl-D-aspartate receptor hyp...
#1Elizabeth M. Tunbridge (University of Oxford)H-Index: 24
#2Marco Narajos (University of Oxford)
Last.Paul J. Harrison (University of Oxford)H-Index: 105
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Abstract Background Many polymorphisms in dopamine genes are reported to affect cognitive, imaging or clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct effect of the polymorphism on the gene product itself. However, the supporting evidence is not always clear. Methods We conducted systematic reviews and meta-analyses to assess the empirical evidence for functional polymorphisms in dopamine enzymes ( COMT , DBH , DDC , MAOA, MAOB and TH )...
Abstract Background Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) share common genetic factors but seem to have specific patterns of psychiatric comorbidities. There are few systematic studies on adults; therefore, we compared psychiatric comorbidities in adults with these two neurodevelopmental disorders using population-based data and analyzed their genetic correlations to evaluate underlying factors. Methods Using data from Norwegian registries, we assesse...
Last.Dawn X. P. Koh (Agency for Science, Technology and Research)H-Index: 1
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Abstract Background Genetic polymorphisms of the dopamine transporter gene ( DAT1 ) and perinatal complications associated with poor oxygenation are risk factors for attentional problems in childhood and may show interactive effects. Methods We created a novel expression-based polygenic risk score (ePRS) reflecting variations in the function of the DAT1 gene network (ePRS- DAT1 ) in the prefrontal cortex and explored the effects of its interaction with perinatal hypoxic-ischemic–associated condi...
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