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Mark Slifstein
Stony Brook University
201Publications
53H-index
10kCitations
Publications 201
Newest
Published on Apr 26, 2019in Neuropsychopharmacology7.16
Diana Martinez27
Estimated H-index: 27
(Columbia University),
Mark Slifstein53
Estimated H-index: 53
(Columbia University)
+ 11 AuthorsDinnisa Chang (Columbia University)
Animal studies indicate that the kappa-opioid receptor/dynorphin system plays an important role in cocaine binges and stress-induced relapse. Our goal was to investigate changes in kappa-opioid receptor (KOR) availability in the human brain using positron emission tomography (PET), before and after a cocaine binge. We also investigated the correlation between KOR and stress-induced cocaine self-administration. PET imaging was performed with the KOR selective agonist [11C]GR103545. Subjects with ...
Published on Apr 1, 2019in Biological Psychiatry11.50
Bret R. Rutherford18
Estimated H-index: 18
(Columbia University),
Mark Slifstein53
Estimated H-index: 53
(SBU: Stony Brook University)
+ 8 AuthorsEmily Valente
Abstract Background A high-risk subgroup of older patients with depression has slowed processing and gait speeds. This study examined whether carbidopa/levodopa (L-DOPA) monotherapy increased dopamine availability, increased processing/gait speed, and relieved depressive symptoms. Methods Adult outpatients with depression >59 years old underwent baseline [ 11 C]raclopride positron emission tomography followed by open L-DOPA for 3 weeks (1 week each of 150 mg, 300 mg, and 450 mg). Generalized est...
Published on May 1, 2019in Biological Psychiatry11.50
Bret R. Rutherford1
Estimated H-index: 1
,
Mark Slifstein53
Estimated H-index: 53
+ 4 AuthorsSteven P. Roose52
Estimated H-index: 52
Published on May 1, 2019in Molecular metabolism6.18
Judith Korner25
Estimated H-index: 25
(Columbia University),
Gary W. Cline68
Estimated H-index: 68
(Yale University)
+ 6 AuthorsPaul E. Harris34
Estimated H-index: 34
(Columbia University)
Abstract Objective We hypothesized that DA and L-DOPA derived from nutritional tyrosine and the resultant observed postprandial plasma excursions of L-DOPA and DA might affect glucose tolerance via their ability to be taken-up by beta cells and inhibit glucose-stimulated β-cell insulin secretion. Methods To investigate a possible circuit between meal-stimulated 3,4-dihydroxy-L-phenylalanine (L-DOPA) and dopamine (DA) production in the GI tract and pancreatic β-cells, we: 1) mapped GI mucosal exp...
Published on May 1, 2019in Biological Psychiatry11.50
Anissa Abi-Dargham63
Estimated H-index: 63
,
Jared X. Van Snellenberg15
Estimated H-index: 15
+ 3 AuthorsJeffrey A. Lieberman126
Estimated H-index: 126
Published on May 1, 2019in Biological Psychiatry11.50
Mala Ananth6
Estimated H-index: 6
,
Mark Slifstein53
Estimated H-index: 53
+ 4 AuthorsChristine DeLorenzo16
Estimated H-index: 16
Published on Feb 1, 2019in Journal of Cerebral Blood Flow and Metabolism6.04
Martin Nørgaard2
Estimated H-index: 2
(UCPH: University of Copenhagen),
Melanie Ganz7
Estimated H-index: 7
(UCPH: University of Copenhagen)
+ 14 AuthorsEugenii A Rabiner1
Estimated H-index: 1
(Wellcome Trust Centre for Neuroimaging)
Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to dif...
Lawrence S. Kegeles44
Estimated H-index: 44
(Columbia University),
Guillermo Horga17
Estimated H-index: 17
(Columbia University)
+ 8 AuthorsJohn H. Krystal113
Estimated H-index: 113
(Yale University)
Abstract Background We used PET imaging with [ 11 C]raclopride to examine the effects of consumption of alcohol or placebo beverage by participants with alcohol use disorder (AUD) compared to healthy participants with and without family history of AUD. We sought to assess dopamine release following alcohol exposure in relation to AUD risk. Methods Three groups were enrolled: participants with AUD (n = 15), and healthy participants with family history negative (FHN, n=34) or positive (FHP, n=16) ...
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