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Mark Slifstein
Stony Brook University
201Publications
53H-index
10kCitations
Publications 201
Newest
#1Jonathan M. Wai (Columbia University)H-Index: 1
#2Alexander Grassetti (Columbia University)H-Index: 1
Last.Diana Martinez (Columbia University)H-Index: 27
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Abstract Background Previous imaging studies using Positron Emission Tomography (PET) have shown that alcohol use disorder (AUD) is associated with a decrease in dopamine type 2/3 receptor (D2/3) binding and dopamine transmission. Although binge drinking is a risk factor for future AUD, little is known about the neurobiology of binge drinking in young adults. This study measured D2/3 receptor binding and stimulant-induced dopamine release using PET and [11C]raclopride in binge drinkers without a...
#1Diana Martinez (Columbia University)H-Index: 27
#2Mark Slifstein (Columbia University)H-Index: 53
Last.Yiyun Huang (Yale University)H-Index: 23
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Animal studies indicate that the kappa-opioid receptor/dynorphin system plays an important role in cocaine binges and stress-induced relapse. Our goal was to investigate changes in kappa-opioid receptor (KOR) availability in the human brain using positron emission tomography (PET), before and after a cocaine binge. We also investigated the correlation between KOR and stress-induced cocaine self-administration. PET imaging was performed with the KOR selective agonist [11C]GR103545. Subjects with ...
#1Bret R. Rutherford (Columbia University)H-Index: 18
#2Mark Slifstein (SBU: Stony Brook University)H-Index: 53
Last.Steven P. Roose (Columbia University)H-Index: 52
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Abstract Background A high-risk subgroup of older patients with depression has slowed processing and gait speeds. This study examined whether carbidopa/levodopa (L-DOPA) monotherapy increased dopamine availability, increased processing/gait speed, and relieved depressive symptoms. Methods Adult outpatients with depression >59 years old underwent baseline [ 11 C]raclopride positron emission tomography followed by open L-DOPA for 3 weeks (1 week each of 150 mg, 300 mg, and 450 mg). Generalized est...
#1Judith Korner (Columbia University)H-Index: 25
#2Gary W. Cline (Yale University)H-Index: 68
Last.Paul E. Harris (Columbia University)H-Index: 34
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Abstract Objective We hypothesized that DA and L-DOPA derived from nutritional tyrosine and the resultant observed postprandial plasma excursions of L-DOPA and DA might affect glucose tolerance via their ability to be taken-up by beta cells and inhibit glucose-stimulated β-cell insulin secretion. Methods To investigate a possible circuit between meal-stimulated 3,4-dihydroxy-L-phenylalanine (L-DOPA) and dopamine (DA) production in the GI tract and pancreatic β-cells, we: 1) mapped GI mucosal exp...
#1Martin Nørgaard (UCPH: University of Copenhagen)H-Index: 2
#2Melanie Ganz (UCPH: University of Copenhagen)H-Index: 7
Last.Gitte M. Knudsen (UCPH: University of Copenhagen)H-Index: 52
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Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to dif...
#1Lawrence S. Kegeles (Columbia University)H-Index: 44
#2Guillermo Horga (Columbia University)H-Index: 17
Last.Anissa Abi-Dargham (Columbia University)H-Index: 63
view all 11 authors...
Abstract Background We used PET imaging with [ 11 C]raclopride to examine the effects of consumption of alcohol or placebo beverage by participants with alcohol use disorder (AUD) compared to healthy participants with and without family history of AUD. We sought to assess dopamine release following alcohol exposure in relation to AUD risk. Methods Three groups were enrolled: participants with AUD (n = 15), and healthy participants with family history negative (FHN, n=34) or positive (FHP, n=16) ...
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