Original paper
Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging
Abstract
Osteocyte survival is key to bone homeostasis and is perturbed in menopause and aging. However, it remains unknown how osteocyte-mediated maintenance of the skeleton is regulated by the osteoprotective factor semaphorin 3A (Sema3A), a secreted protein that is known to reduce bone resorption and enhance bone formation. Here, we show that estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote their...
Paper Details
Title
Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging
Published Date
Mar 1, 2019
Journal
Volume
29
Issue
3
Pages
627 - 637.e5
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Notes
History