Cell Metabolism
Papers 2764
1 page of 277 pages (2,764 results)
Published on Jun 1, 2019in Cell Metabolism22.41
Liang Wei Wang3
Estimated H-index: 3
(Harvard University),
Hongying Shen11
Estimated H-index: 11
(Broad Institute)
+ 14 AuthorsBryn Reinstadler (Broad Institute)
Summary Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were profiled by tandem-mass-tag-based proteomics at rest and at nine time points after infection; >8,000 host and 29 viral proteins were quantified, revealing mitochondrial remodeling and induction of one-carbon (1C) metabolism. EBV-encoded EBNA2 and its target MYC we...
Published on Sep 1, 2019in Cell Metabolism22.41
Saara Forsström6
Estimated H-index: 6
(UH: University of Helsinki),
Christopher B. Jackson8
Estimated H-index: 8
(UH: University of Helsinki)
+ 17 AuthorsNahid A. Khan3
Estimated H-index: 3
(UH: University of Helsinki)
Summary Mitochondrial dysfunction elicits stress responses that safeguard cellular homeostasis against metabolic insults. Mitochondrial integrated stress response (ISRmt) is a major response to mitochondrial (mt)DNA expression stress (mtDNA maintenance, translation defects), but the knowledge of dynamics or interdependence of components is lacking. We report that in mitochondrial myopathy, ISRmt progresses in temporal stages and development from early to chronic and is regulated by autocrine and...
Published on Sep 1, 2019in Cell Metabolism22.41
Damien J. Cabral3
Estimated H-index: 3
(Brown University),
Swathi Penumutchu1
Estimated H-index: 1
(Brown University)
+ 9 AuthorsAislinn D. Rowan-Nash1
Estimated H-index: 1
(Brown University)
Summary Although antibiotics disturb the structure of the gut microbiota, factors that modulate these perturbations are poorly understood. Bacterial metabolism is an important regulator of susceptibility in vitro and likely plays a large role within the host. We applied a metagenomic and metatranscriptomic approach to link antibiotic-induced taxonomic and transcriptional responses within the murine microbiome. We found that antibiotics significantly alter the expression of key metabolic pathways...
Published on Jun 1, 2019in Cell Metabolism22.41
Mengqi Li5
Estimated H-index: 5
(Ha Tai: Xiamen University),
Chen-Song Zhang10
Estimated H-index: 10
(Ha Tai: Xiamen University)
+ 28 AuthorsYaying Wu (Ha Tai: Xiamen University)
Summary Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease of calcium at contact sites between ER and lysosom...
Published on Sep 1, 2019in Cell Metabolism22.41
Leonie K. Heilbronn37
Estimated H-index: 37
(University of Adelaide),
Satchidananda Panda49
Estimated H-index: 49
(Salk Institute for Biological Studies)
Various forms of fasting improve health and longevity in preclinical models. However, safety, outcomes, and the molecular changes underpinning human fasting are unclear. Stekovic et al. (2019) report improved markers of health for up to 6 months and associated metabolic changes among healthy adults who followed alternate-day fasting.
Published on Sep 1, 2019in Cell Metabolism22.41
Jiyeon J. Kim1
Estimated H-index: 1
(UIC: University of Illinois at Chicago),
Ralph J. DeBerardinis64
Estimated H-index: 64
(UTSW: University of Texas Southwestern Medical Center)
Tumors display reprogrammed metabolic activities that promote cancer progression. We currently possess a limited understanding of the processes governing tumor metabolism in vivo and of the most efficient approaches to identify metabolic vulnerabilities susceptible to therapeutic targeting. While much of the literature focuses on stereotyped, cell-autonomous pathways like glycolysis, recent work emphasizes heterogeneity and flexibility of metabolism between tumors and even within distinct region...
Published on Sep 1, 2019in Cell Metabolism22.41
Xuri Li28
Estimated H-index: 28
(SYSU: Sun Yat-sen University),
Xiaodong Sun (SJTU: Shanghai Jiao Tong University), Peter Carmeliet141
Estimated H-index: 141
(Katholieke Universiteit Leuven)
In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the orders of growth factors if these cells would accordingly adapt their metabolism. Ten years later, it has become clear that ECs, often differently from other cell types, rely on distinct metabolic pathways to survive and form new blood vessels; that manipulation of EC metabolic pathways alone (even without changing angiogenic signaling) suffices to alter vessel sprouting; and that perturbations of these met...
Published on Sep 1, 2019in Cell Metabolism22.41
Slaven Stekovic6
Estimated H-index: 6
(University of Graz),
Sebastian Hofer5
Estimated H-index: 5
(University of Graz)
+ 28 AuthorsJasmin Url2
Estimated H-index: 2
(Medical University of Graz)
Summary Caloric restriction and intermittent fasting are known to prolong life- and healthspan in model organisms, while their effects on humans are less well studied. In a randomized controlled trial study ( identifier: NCT02673515 ), we show that 4 weeks of strict alternate day fasting (ADF) improved markers of general health in healthy, middle-aged humans while causing a 37% calorie reduction on average. No adverse effects occurred even after >6 months. ADF improved cardiov...
Published on Sep 1, 2019in Cell Metabolism22.41
Jl McCarville1
Estimated H-index: 1
(Salk Institute for Biological Studies),
Janelle S. Ayres17
Estimated H-index: 17
(Salk Institute for Biological Studies)
During infection, disease tolerance promotes host health without killing the pathogen. In a recent issue of Cell, Luan et al. (2019) identify GDF15 as a central regulator of disease tolerance of bacterial and viral challenges, while preventing cardiac damage, by mediating downstream cross-organ communication via the sympathetic and metabolic systems.
Published on Sep 1, 2019in Cell Metabolism22.41
Julian Meyer Berger1
Estimated H-index: 1
(Columbia University),
Parminder Singh6
Estimated H-index: 6
+ 10 AuthorsVijay K. Yadav19
Estimated H-index: 19
(Columbia University)
Summary We hypothesized that bone evolved, in part, to enhance the ability of bony vertebrates to escape danger in the wild. In support of this notion, we show here that a bone-derived signal is necessary to develop an acute stress response (ASR). Indeed, exposure to various types of stressors in mice, rats (rodents), and humans leads to a rapid and selective surge of circulating bioactive osteocalcin because stressors favor the uptake by osteoblasts of glutamate, which prevents inactivation of ...