Cell Metabolism
Papers 2809
1 page of 281 pages (2,809 results)
#1Ana Latorre-Pellicer (University of Zaragoza)
#2Ana Victoria Lechuga-Vieco (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 9
Last.José Antonio Enríquez (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 50
view all 17 authors...
Summary mtDNA is present in multiple copies in each cell derived from the expansions of those in the oocyte. Heteroplasmy, more than one mtDNA variant, may be generated by mutagenesis, paternal mtDNA leakage, and novel medical technologies aiming to prevent inheritance of mtDNA-linked diseases. Heteroplasmy phenotypic impact remains poorly understood. Mouse studies led to contradictory models of random drift or haplotype selection for mother-to-offspring transmission of mtDNA heteroplasmy. Here,...
#1Jiajun Zhu (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 2
#2Mirela Berisa (MSK: Memorial Sloan Kettering Cancer Center)
Last.Craig B. Thompson (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 166
view all 6 authors...
Summary Cysteine acts both as a building unit for protein translation and as the limiting substrate for glutathione synthesis to support the cellular antioxidant system. In addition to transporter-mediated uptake, cellular cysteine can also be synthesized from methionine through the transsulfuration pathway. Here, we investigate the regulation of transsulfuration and its role in sustaining cell proliferation upon extracellular cysteine limitation, a condition reported to occur in human tumors as...
#1Damien J. Cabral (Brown University)H-Index: 4
#2Swathi Penumutchu (Brown University)H-Index: 2
Last.Peter Belenky (Brown University)H-Index: 16
view all 12 authors...
Summary Although antibiotics disturb the structure of the gut microbiota, factors that modulate these perturbations are poorly understood. Bacterial metabolism is an important regulator of susceptibility in vitro and likely plays a large role within the host. We applied a metagenomic and metatranscriptomic approach to link antibiotic-induced taxonomic and transcriptional responses within the murine microbiome. We found that antibiotics significantly alter the expression of key metabolic pathways...
2 CitationsSource
#1Emily L. Goldberg (Yale University)H-Index: 9
#2Vishwa Deep Dixit (Yale University)H-Index: 28
An integrated immunometabolic response during negative energy balance is required for host survival. Three new papers by Jordan et al., 2019 , Nagai et al., 2019 , and Collins et al. (2019) report that monocytes, naive B cells, and memory CD8 T cells use bone marrow as a haven to tide off periods of metabolic adversity to maintain immune-responsiveness.
#1Samir Softic (Harvard University)H-Index: 14
#2Jesse G. Meyer (Buck Institute for Research on Aging)H-Index: 8
Last.C Ronaldkahn (Harvard University)H-Index: 159
view all 17 authors...
Summary Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the effects of a high-fat diet (HFD) on the development of insulin resistance. Here, we show that fructose and glucose supplementation of an HFD exert divergent effects on hepatic mitochondrial function and fatty acid oxidation. This is mediated via three different nodes of regulation, including differential effects on malonyl-CoA levels, effects on mitochondrial size/protein abundance, and acetylation o...
1 CitationsSource
#1Clarissa Campbell (MSK: Memorial Sloan Kettering Cancer Center)
#2Alexander Y. Rudensky (Cornell University)H-Index: 106
Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function an...
#1José Manuel Bravo-San Pedro (University of Paris)H-Index: 1
#2Valentina Sica (University of Paris)H-Index: 11
Last.Guido KroemerH-Index: 197
view all 34 authors...
Summary Autophagy facilitates the adaptation to nutritional stress. Here, we show that short-term starvation of cultured cells or mice caused the autophagy-dependent cellular release of acyl-CoA-binding protein (ACBP, also known as diazepam-binding inhibitor, DBI) and consequent ACBP-mediated feedback inhibition of autophagy. Importantly, ACBP levels were elevated in obese patients and reduced in anorexia nervosa. In mice, systemic injection of ACBP protein inhibited autophagy, induced lipogenes...
3 CitationsSource
#1Elizabeth Rendina-Ruedy (VUMC: Vanderbilt University Medical Center)
#2Clifford J. Rosen (Maine Medical Center)H-Index: 94
Because of heavy energy demands to maintain bone homeostasis, the skeletal system is closely tied to whole-body metabolism via neuronal and hormonal mediators. Glucose, amino acids, and fatty acids are the chief fuel sources for bone resident cells during its remodeling. Lipids, which can be mobilized from intracellular depots in the bone marrow, can be a potent source of fatty acids. Thus, while it has been suggested that adipocytes in the bone marrow act as “filler” and are detrimental to skel...
#1Marcelo A. Mori (State University of Campinas)H-Index: 26
#2Raissa G. Ludwig (State University of Campinas)H-Index: 1
Last.C Ronaldkahn (Harvard University)H-Index: 159
view all 5 authors...
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of distal cells. When impaired, these processes can lead to tissue dysfunction, aging, and disease. Adipose tissue is an especially important contributor to the pool of circulating ex...
#1Sofie Lautrup (Ahus: Akershus University Hospital)H-Index: 4
#2A SinclairDavid (UNSW: University of New South Wales)H-Index: 88
Last.Evandro F. Fang (Ahus: Akershus University Hospital)H-Index: 2
view all 4 authors...
NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurr...
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Diabetes mellitus
Cell biology