Cell Metabolism
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Published on Jan 1, 2019in Cell Metabolism 20.57
Lingyun Li3
Estimated H-index: 3
(Saint Louis University),
Xia Liu3
Estimated H-index: 3
(Saint Louis University)
+ 9 AuthorsDavid A. Ford31
Estimated H-index: 31
(Saint Louis University)
Summary Regulatory T (Treg) cells induce an immunosuppressive microenvironment that is a major obstacle for successful tumor immunotherapy. Dissecting the regulatory mechanisms between energy metabolism and functionality in Treg cells will provide insight toward developing novel immunotherapies against cancer. Here we report that human naturally occurring and tumor-associated Treg cells exhibit distinct metabolic profiles with selectivity for glucose metabolism compared with effector T cells. Tr...
4 Citations Source Cite
Published on Mar 1, 2019in Cell Metabolism 20.57
Esther Latres15
Estimated H-index: 15
,
Daniel Finan1
Estimated H-index: 1
+ 2 AuthorsTimothy J. Kieffer48
Estimated H-index: 48
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Published on Feb 1, 2019in Cell Metabolism 20.57
Anthony Venida1
Estimated H-index: 1
(University of California, San Francisco),
Rushika M. Perera22
Estimated H-index: 22
(University of California, San Francisco)
Cancer cells are dependent on functional autophagy both within their cytoplasm and systemically in the host to maintain growth. How systemic autophagy directly contributes to tumor growth remains unclear. In a study published in Nature , Poillet-Perez et al. (2018) show that host autophagy helps to maintain the levels of circulating arginine that feed tumor growth.
1 Citations Source Cite
Published on Feb 1, 2019in Cell Metabolism 20.57
Patrycja Puchalska1
Estimated H-index: 1
(University of Minnesota),
Shannon E. Martin1
Estimated H-index: 1
(Brown University)
+ 7 AuthorsPeter A. Crawford28
Estimated H-index: 28
(University of Minnesota)
Summary Metabolic plasticity has been linked to polarized macrophage function, but mechanisms connecting specific fuels to tissue macrophage function remain unresolved. Here we apply a stable isotope tracing, mass spectrometry-based untargeted metabolomics approach to reveal the metabolome penetrated by hepatocyte-derived glucose and ketone bodies. In both classically and alternatively polarized macrophages, [ 13 C]acetoacetate (AcAc) labeled ∼200 chemical features, but its reduced form D-[ 13 C...
1 Citations Source Cite
Published on Mar 1, 2019in Cell Metabolism 20.57
Mikihito Hayashi7
Estimated H-index: 7
(Tokyo Medical and Dental University),
Tomoki Nakashima36
Estimated H-index: 36
(Tokyo Medical and Dental University)
+ 3 AuthorsHiroshi Takayanagi61
Estimated H-index: 61
(University of Tokyo)
Summary Osteocyte survival is key to bone homeostasis and is perturbed in menopause and aging. However, it remains unknown how osteocyte-mediated maintenance of the skeleton is regulated by the osteoprotective factor semaphorin 3A (Sema3A), a secreted protein that is known to reduce bone resorption and enhance bone formation. Here, we show that estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote their survival and maintain bone homeostasis. Postna...
1 Citations Source Cite
Published on Mar 1, 2019in Cell Metabolism 20.57
Diane C. Saunders2
Estimated H-index: 2
(Vanderbilt University),
Marcela Brissova27
Estimated H-index: 27
(Vanderbilt University Medical Center)
+ 20 AuthorsJulie Pelletier13
Estimated H-index: 13
(Laval University)
Summary Identification of cell-surface markers specific to human pancreatic β cells would allow in vivo analysis and imaging. Here we introduce a biomarker, ectonucleoside triphosphate diphosphohydrolase-3 (NTPDase3), that is expressed on the cell surface of essentially all adult human β cells, including those from individuals with type 1 or type 2 diabetes. NTPDase3 is expressed dynamically during postnatal human pancreas development, appearing first in acinar cells at birth, but several months...
1 Citations Source Cite
Published on Jan 1, 2019in Cell Metabolism 20.57
Miriam Toledo2
Estimated H-index: 2
(Albert Einstein College of Medicine),
Rajat Singh27
Estimated H-index: 27
Summary Autophagy prevents pancreatic β cell death during obesity, although the mechanism of autophagy activation in the β cell has remained elusive. In this issue of Cell Metabolism , King et al. (2018) show that intracellular complement component C3 interacts with autophagy protein ATG16L1 and protects against β cell death by stimulating autophagy.
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Published on Mar 1, 2019in Cell Metabolism 20.57
Tetsuro Kobayashi37
Estimated H-index: 37
,
Keisuke Nagao21
Estimated H-index: 21
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Published on Feb 1, 2019in Cell Metabolism 20.57
Saul Soberanes19
Estimated H-index: 19
(Northwestern University),
Alexander V. Misharin20
Estimated H-index: 20
(Northwestern University)
+ 29 AuthorsJames McCauley Walter6
Estimated H-index: 6
(Northwestern University)
Summary Urban particulate matter air pollution induces the release of pro-inflammatory cytokines including interleukin-6 (IL-6) from alveolar macrophages, resulting in an increase in thrombosis. Here, we report that metformin provides protection in this murine model. Treatment of mice with metformin or exposure of murine or human alveolar macrophages to metformin prevented the particulate matter-induced generation of complex III mitochondrial reactive oxygen species, which were necessary for the...
1 Citations Source Cite
Published on Feb 1, 2019in Cell Metabolism 20.57
Michinari Nakamura6
Estimated H-index: 6
(Rutgers University),
Tong Liu24
Estimated H-index: 24
(Rutgers University)
+ 9 AuthorsBin Tian44
Estimated H-index: 44
(Rutgers University)
Summary Obesity induces lipotoxic cardiomyopathy, a condition in which lipid accumulation in cardiomyocytes causes cardiac dysfunction. Here, we show that glycogen synthase kinase-3α (GSK-3α) mediates lipid accumulation in the heart. Fatty acids (FAs) upregulate GSK-3α, which phosphorylates PPARα at Ser280 in the ligand-binding domain (LBD). This modification ligand independently enhances transcription of a subset of PPARα targets, selectively stimulating FA uptake and storage, but not oxidation...
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