scinapse is loading now...
Cell Metabolism
IF
20.57
Papers
2718
Papers 2709
1 page of 271 pages (2,709 results)
Newest
Published on Jun 6, 2019in Cell Metabolism 20.57
Source Cite
Published on Mar 1, 2019in Cell Metabolism 20.57
Francesca Sacco11
Estimated H-index: 11
(University of Rome Tor Vergata),
Anett Seelig + 6 AuthorsMatthias Mann193
Estimated H-index: 193
(Max Planck Society)
Summary Progressive decline of pancreatic beta cell function is central to the pathogenesis of type 2 diabetes. Protein phosphorylation regulates glucose-stimulated insulin secretion from beta cells, but how signaling networks are remodeled in diabetic islets in vivo remains unknown. Using high-sensitivity mass spectrometry-based proteomics, we quantified 6,500 proteins and 13,000 phosphopeptides in islets of obese diabetic mice and matched controls, revealing drastic remodeling of key kinase hu...
Source Cite
Published on Apr 1, 2019in Cell Metabolism 20.57
Angela Molinaro (University of Gothenburg), Barbara Becattini13
Estimated H-index: 13
(University of Gothenburg)
+ 7 AuthorsGiovanni Solinas20
Estimated H-index: 20
(University of Gothenburg)
Summary Phosphatidylinositol-3-kinase (PI3K) activity is aberrant in tumors, and PI3K inhibitors are investigated as cancer therapeutics. PI3K signaling mediates insulin action in metabolism, but the role of PI3K isoforms in insulin signaling remains unresolved. Defining the role of PI3K isoforms in insulin signaling is necessary for a mechanistic understanding of insulin action and to develop PI3K inhibitors with optimal therapeutic index. We show that insulin-driven PI3K-AKT signaling depends ...
Source Cite
Published on May 1, 2019in Cell Metabolism 20.57
Grzegorz Godlewski24
Estimated H-index: 24
(National Institutes of Health),
Resat Cinar19
Estimated H-index: 19
(National Institutes of Health)
+ 11 AuthorsMalliga R. Iyer8
Estimated H-index: 8
(National Institutes of Health)
Summary Endocannabinoids acting on the cannabinoid-1 receptor (CB 1 R) or ghrelin acting on its receptor (GHS-R 1A ) both promote alcohol-seeking behavior, but an interaction between the two signaling systems has not been explored. Here, we report that the peripheral CB 1 R inverse agonist JD5037 reduces ethanol drinking in wild-type mice but not in mice lacking CB 1 R, ghrelin peptide or GHS-R 1A . JD5037 treatment of alcohol-drinking mice inhibits the formation of biologically active octanoyl-...
Source Cite
Published on Mar 1, 2019in Cell Metabolism 20.57
Hisayuki Amano1
Estimated H-index: 1
(Baylor College of Medicine),
Arindam Chaudhury10
Estimated H-index: 10
(Baylor College of Medicine)
+ 16 AuthorsFabio Stossi21
Estimated H-index: 21
(Baylor College of Medicine)
Summary Telomere shortening is associated with stem cell decline, fibrotic disorders, and premature aging through mechanisms that are incompletely understood. Here, we show that telomere shortening in livers of telomerase knockout mice leads to a p53-dependent repression of all seven sirtuins. P53 regulates non-mitochondrial sirtuins (Sirt1, 2, 6, and 7) post-transcriptionally through microRNAs (miR-34a, 26a, and 145), while the mitochondrial sirtuins (Sirt3, 4, and 5) are regulated in a peroxis...
Source Cite
Published on Feb 1, 2019in Cell Metabolism 20.57
Christopher J. Halbrook5
Estimated H-index: 5
(University of Michigan),
Corbin Pontious1
Estimated H-index: 1
(University of Michigan)
+ 20 AuthorsPeter Sajjakulnukit1
Estimated H-index: 1
(University of Michigan)
Summary Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant infiltration of tumor-associated macrophages (TAMs). TAMs have been reported to drive resistance to gemcitabine, a frontline chemotherapy in PDA, though the mechanism of this resistance remains unclear. Profiling metabolite exchange, we demonstrate that macrophages programmed by PDA cells release a spectrum of pyrimidine species. These include deoxycytidine, which inhibits gemcitabine through molecular competition at the...
5 Citations Source Cite
Published on Apr 1, 2019in Cell Metabolism 20.57
Jae Woo Jung3
Estimated H-index: 3
(Seoul National University),
Stephani Joy Y. Macalino4
Estimated H-index: 4
(Ewha Womans University)
+ 7 AuthorsJung Weon Lee31
Estimated H-index: 31
(Seoul National University)
Summary The mechanistic target of rapamycin complex (mTORC1) is a signaling hub on the lysosome surface, responding to lysosomal amino acids. Although arginine is metabolically important, the physiological arginine sensor that activates mTOR remains unclear. Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation. TM4SF5 bound active mTOR upon arginine suff...
Source Cite
Published on Mar 1, 2019in Cell Metabolism 20.57
Mark R Sullivan3
Estimated H-index: 3
(Massachusetts Institute of Technology),
Katherine R. Mattaini10
Estimated H-index: 10
(Massachusetts Institute of Technology)
+ 9 AuthorsMarcus Bosenberg38
Estimated H-index: 38
(Yale University)
Summary Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate expression of serine synthesis pathway enzymes, and some tumors exhibit copy-number gain of the gene encoding the first enzyme in the pathway, phosphoglycerate dehydrogenase ( PHGDH ). However, whether increased serine synthesis promotes tumor growth and how serine synthesis benefits tumors is controversial. Here, we demonstrate that increased PHGDH expression promotes tumor progression in mouse models ...
3 Citations Source Cite
Published on Feb 1, 2019in Cell Metabolism 20.57
Liming Du6
Estimated H-index: 6
(Shanghai Jiao Tong University),
Liangyu Lin3
Estimated H-index: 3
(Shanghai Jiao Tong University)
+ 10 AuthorsFengying Li4
Estimated H-index: 4
(Shanghai Jiao Tong University)
Summary Recent investigations revealed that macrophages could be trained with an altered responsiveness, raising the possibility of combating autoimmune diseases by imparting anti-inflammatory capabilities to these cells. While investigating the effect of mesenchymal stem cells on experimental autoimmune encephalomyelitis (EAE), we found a critical role of insulin-like growth factor 2 (IGF-2) in training macrophages to become anti-inflammatory during their maturation. IGF-2 exerts its effects by...
Source Cite
Published on Apr 1, 2019in Cell Metabolism 20.57
Elsa Sánchez-López24
Estimated H-index: 24
(University of California, San Diego),
Zhenyu Zhong14
Estimated H-index: 14
(University of California, San Diego)
+ 12 AuthorsJuan Carlos Lacal3
Estimated H-index: 3
Summary Choline is a vitamin-like nutrient that is taken up via specific transporters and metabolized by choline kinase, which converts it to phosphocholine needed for de novo synthesis of phosphatidylcholine (PC), the main phospholipid of cellular membranes. We found that Toll-like receptor (TLR) activation enhances choline uptake by macrophages and microglia through induction of the choline transporter CTL1. Inhibition of CTL1 expression or choline phosphorylation attenuated NLRP3 inflammasome...
1 Citations Source Cite
12345678910