Cell Metabolism
Papers 2885
1 page of 289 pages (2,885 results)
#1Zhonggang Li (UW: University of Wisconsin-Madison)
#2James A. Votava (UW: University of Wisconsin-Madison)
Last. Cara L. Green (UW: University of Wisconsin-Madison)H-Index: 1
view all 19 authors...
Summary Identifying the causal gene(s) that connects genetic variation to a phenotype is a challenging problem in genome-wide association studies (GWASs). Here, we develop a systematic approach that integrates mouse liver co-expression networks with human lipid GWAS data to identify regulators of cholesterol and lipid metabolism. Through our approach, we identified 48 genes showing replication in mice and associated with plasma lipid traits in humans and six genes on the X chromosome. Among thes...
#1Esther van Dam (Imperial College London)
#2Lucie A.G. van Leeuwen (Imperial College London)H-Index: 1
Last. Marcela Buricova (Imperial College London)
view all 17 authors...
Summary High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival is complex and difficult to disentangle. Here, we show that high sugar induces dehydration in adult Drosophila, and water supplementation fully rescues their lifespan. Conversely, the metabolic defects are water-independent, showing uncoupling between sugar-induced obesity and i...
#1Matthias Hepprich (University of Basel)H-Index: 1
#2Sophia J. Wiedemann (University of Basel)
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 10 authors...
Summary Postprandial hypoglycemia is a disabling complication of the treatment of obesity by gastric bypass surgery. So far, no therapy exists, and the underlying mechanisms remain unclear. Here, we hypothesized that glucose-induced IL-1β leads to an exaggerated insulin response in this condition. Therefore, we conducted a placebo-controlled, randomized, double-blind, crossover study with the SGLT2-inhibitor empagliflozin and the IL-1 receptor antagonist anakinra ( NCT03200782...
#1Ruth E. Gimeno (Eli Lilly and Company)H-Index: 6
#2Daniel A. Briere (Eli Lilly and Company)H-Index: 7
Last. Randy J. Seeley (UM: University of Michigan)H-Index: 89
view all 3 authors...
25 years ago, the future of treating obesity and diabetes focused on end organs known to be involved in energy balance and glucose regulation, including the brain, muscle, adipose tissue, and pancreas. Today, the most effective therapies are focused around the gut. This includes surgical options, such as vertical sleeve gastrectomy and Roux-en-Y gastric bypass, that can produce sustained weight loss and diabetes remission but also extends to pharmacological treatments that simulate or amplify va...
#1Lifeng Yang (Princeton University)H-Index: 14
#2Juan Carlos Garcia Canaveras (Princeton University)H-Index: 1
Last. Le Zhan (RU: Rutgers University)H-Index: 9
view all 17 authors...
Summary NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with impaired electron transport chain activity, NADH accumulation can be toxic. To minimize such toxicity, elevated NADH inhibits the classical NADH-producing pathways: glucose, glutamine, and fat oxidation. Here, through deuterium-tracing studies in cultured cells and mice, we show that folate-dependent serine catabolism also produces substantial NADH. Strikingly, when respiration is impaired, serine cat...
#1Chloé Berland (University of Paris)
#2Enrica Montalban (University of Paris)H-Index: 2
Last. Claire Martin (University of Paris)
view all 28 authors...
Summary Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL) system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the mechanisms by which nutrients influence the MCL circuitry remain elusive. Here, we show that nutritional triglycerides (TGs), a conserved post-prandial metabolic signature among mammals, can be metabolized within the MCL system and modulate DA-associated behaviors by gating the activity of dopamine receptor subtype...
#1Fabien DucrocqH-Index: 2
#2Roman WalleH-Index: 1
Last. Pierre TrifilieffH-Index: 19
view all 25 authors...
#1Qi Han (IU: Indiana University)H-Index: 2
#2Yuxiang Xie (NIH: National Institutes of Health)H-Index: 9
Last. Xiao-Ming Xu (IU: Indiana University)H-Index: 43
view all 10 authors...
Summary Axonal regeneration in the central nervous system (CNS) is a highly energy-demanding process. Extrinsic insults and intrinsic restrictions lead to an energy crisis in injured axons, raising the question of whether recovering energy deficits facilitates regeneration. Here, we reveal that enhancing axonal mitochondrial transport by deleting syntaphilin (Snph) recovers injury-induced mitochondrial depolarization. Using three CNS injury mouse models, we demonstrate that Snph−/− mice display ...
#1Emily M. Teichman (UCC: University College Cork)H-Index: 1
#2Kenneth J. O'Riordan (UCC: University College Cork)H-Index: 2
Last. John F. Cryan (UCC: University College Cork)H-Index: 91
view all 5 authors...
The microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and behavior. The composition of the gut microbiota is subject to diurnal variation and is entrained by host circadian rhythms. In turn, a diverse microbiota is essential for optimal regulation of host circadian pathways. Disruption of the cyclical nature of this microbe-host interaction profoundly influences disease pathology and severity. This r...
Top fields of study
Diabetes mellitus
Cell biology