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Tomoki Nakashima
Tokyo Medical and Dental University
ImmunologyOsteoclastRANKLBone resorptionBiology
106Publications
37H-index
6,737Citations
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Publications 109
Newest
#1Yoshitaka Kameo (Kyoto University)H-Index: 9
#2Yuki Miya (Kyoto University)
Last. Taiji AdachiH-Index: 30
view all 5 authors...
Bone structure and function are maintained by well-regulated bone metabolism and remodeling. Although the underlying molecular and cellular mechanisms are now being understood, physiological and pathological states of bone are still difficult to predict due to the complexity of intercellular signaling. We have now developed a novel in silico experimental platform, V-Bone, to integratively explore bone remodeling by linking complex microscopic molecular/cellular interactions to macroscopic tissue...
1 CitationsSource
#1Takehito OnoH-Index: 11
Last. Tomoki NakashimaH-Index: 37
view all 4 authors...
Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signaling receptor RANK, or decoy receptor osteoprotegerin (OPG) lead to bone diseases such as osteopetrosis, the RANKL/RANK/OPG system is essential for bone resorption. RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, in...
3 CitationsSource
#1Fumiyuki Sasaki (Tokyo Medical and Dental University)H-Index: 1
#2Mikihito Hayashi (Tokyo Medical and Dental University)H-Index: 7
Last. Tomoki Nakashima (Tokyo Medical and Dental University)H-Index: 37
view all 6 authors...
Abstract Osteocytes function as critical regulators of bone homeostasis by coordinating the functions of osteoblasts and osteoclasts, and are constantly exposed to mechanical force. However, the molecular mechanism underlying the mechanical signal transduction in osteocytes is not well understood. Here, we found that Yoda1, a selective Piezo1 agonist, increased intracellular calcium mobilization and dose-dependently decreased the expression of Sost (encoding Sclerostin) in the osteocytic cell li...
2 CitationsSource
#1Yusoon Kim (Tokyo Medical and Dental University)
#2Mikihito Hayashi (Tokyo Medical and Dental University)H-Index: 7
Last. Tomoki Nakashima (Tokyo Medical and Dental University)H-Index: 37
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AbstractObjectives: To investigate the role of non-receptor tyrosine kinases (NRTKs) in inflammation-induced osteoclastogenesis.Methods: Microarray analyses of global mRNA expression during recepto...
Source
#1Jing‐yi Xue (YCU: Yokohama City University)
#2Zheng Wang (Peking Union Medical College)H-Index: 11
Last. Long GuoH-Index: 6
view all 10 authors...
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#1Masamu Inoue (Tokyo Medical and Dental University)H-Index: 1
#2Takehito Ono (Tokyo Medical and Dental University)H-Index: 11
Last. Tomoki Nakashima (Tokyo Medical and Dental University)H-Index: 37
view all 7 authors...
Bone undergoes a constant reconstruction process of resorption and formation called bone remodeling, so that it can endure mechanical loading. During food ingestion, masticatory muscles generate the required masticatory force. The magnitude of applied masticatory force has long been believed to be closely correlated with the shape of the jawbone. However, both the mechanism underlying this correlation and evidence of causation remain largely to be determined. Here, we established a novel mouse m...
1 CitationsSource
#1Mikihito Hayashi (Tokyo Medical and Dental University)H-Index: 7
#2Tomoki Nakashima (Tokyo Medical and Dental University)H-Index: 37
Last. Hiroshi Takayanagi (UTokyo: University of Tokyo)H-Index: 63
view all 6 authors...
Summary Osteocyte survival is key to bone homeostasis and is perturbed in menopause and aging. However, it remains unknown how osteocyte-mediated maintenance of the skeleton is regulated by the osteoprotective factor semaphorin 3A (Sema3A), a secreted protein that is known to reduce bone resorption and enhance bone formation. Here, we show that estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote their survival and maintain bone homeostasis. Postna...
5 CitationsSource
#1Mikihito HayashiH-Index: 7
#2Takehito OnoH-Index: 11
Last. Tomoki NakashimaH-Index: 37
view all 3 authors...
Source
#1Mikihito Hayashi (Japan Agency for Medical Research and Development)H-Index: 7
Last. Tomoki NakashimaH-Index: 37
view all 2 authors...
The Wnt signaling pathway is known to play an important role in various biological processes including embryonic development and tissues homeostasis. Following the identification of the mutations in LRP5, encoding for the Wnt co-receptor low density lipoprotein receptor-related protein 5, associated with bone disorders in human, numerous studies have demonstrated the importance of Wnt signaling in bone cells. The Wnt signaling pathway is one of the key regulators of bone metabolism, hence the tr...
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#1Maia Inoue (UTokyo: University of Tokyo)H-Index: 1
#2Kazuo Okamoto (UTokyo: University of Tokyo)H-Index: 7
Last. Hiroshi Takayanagi (UTokyo: University of Tokyo)H-Index: 63
view all 9 authors...
The methylation of arginine residues in proteins is a post-translational modification that contributes to a wide range of biological processes. Many cytokines involved in T cell development and activation utilize the common cytokine receptor γ-chain (γc) and the kinase JAK3 for signal transduction, but the regulatory mechanism that underlies the expression of these factors remains unclear. Here we found that the arginine methyltransferase PRMT5 was essential for the maintenance of invariant natu...
10 CitationsSource
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