Tomoki Nakashima
Tokyo Medical and Dental University
Publications 94
#1Masamu Inoue (Tokyo Medical and Dental University)
#2T. Ono (Tokyo Medical and Dental University)H-Index: 11
Last.Tomoki Nakashima (Tokyo Medical and Dental University)H-Index: 36
view all 7 authors...
Bone undergoes a constant reconstruction process of resorption and formation called bone remodeling, so that it can endure mechanical loading. During food ingestion, masticatory muscles generate the required masticatory force. The magnitude of applied masticatory force has long been believed to be closely correlated with the shape of the jawbone. However, both the mechanism underlying this correlation and evidence of causation remain largely to be determined. Here, we established a novel mouse m...
#1Mikihito Hayashi (Tokyo Medical and Dental University)H-Index: 7
#2Tomoki Nakashima (Tokyo Medical and Dental University)H-Index: 36
Last.Hiroshi Takayanagi (UTokyo: University of Tokyo)H-Index: 62
view all 6 authors...
Summary Osteocyte survival is key to bone homeostasis and is perturbed in menopause and aging. However, it remains unknown how osteocyte-mediated maintenance of the skeleton is regulated by the osteoprotective factor semaphorin 3A (Sema3A), a secreted protein that is known to reduce bone resorption and enhance bone formation. Here, we show that estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote their survival and maintain bone homeostasis. Postna...
#1Mikihito HayashiH-Index: 7
#2T. OnoH-Index: 11
Last.Tomoki NakashimaH-Index: 36
view all 3 authors...
#1Masayuki Tsukasaki (UTokyo: University of Tokyo)H-Index: 2
#2Noriko Komatsu (UTokyo: University of Tokyo)H-Index: 16
Last.Kazuo Okamoto (UTokyo: University of Tokyo)H-Index: 2
view all 10 authors...
The immune system evolved to efficiently eradicate invading bacteria and terminate inflammation through balancing inflammatory and regulatory T-cell responses. In autoimmune arthritis, pathogenic TH17 cells induce bone destruction and autoimmune inflammation. However, whether a beneficial function of T-cell-induced bone damage exists is unclear. Here, we show that bone-damaging T cells have a critical function in the eradication of bacteria in a mouse model of periodontitis, which is the most co...
#1Yusoon Kim (Tokyo Medical and Dental University)
#2Mikihito Hayashi (Tokyo Medical and Dental University)H-Index: 7
Last.Tomoki Nakashima (Tokyo Medical and Dental University)H-Index: 36
view all 6 authors...
AbstractObjectives: To investigate the role of non-receptor tyrosine kinases (NRTKs) in inflammation-induced osteoclastogenesis.Methods: Microarray analyses of global mRNA expression during receptor activator of NF-κB ligand (RANKL) and RANKL plus tumor necrosis factor (TNF)-α-induced osteoclast differentiation were performed. The inhibitory effect on TNF-α-induced osteoclast differentiation of A-419259, a potent inhibitor of hematopoietic cell kinase (Hck), was examined. The in vivo therapeutic...
#1Maia Inoue (UTokyo: University of Tokyo)H-Index: 1
#2Kazuo Okamoto (UTokyo: University of Tokyo)H-Index: 15
Last.Hiroshi Takayanagi (UTokyo: University of Tokyo)H-Index: 62
view all 9 authors...
The methylation of arginine residues in proteins is a post-translational modification that contributes to a wide range of biological processes. Many cytokines involved in T cell development and activation utilize the common cytokine receptor γ-chain (γc) and the kinase JAK3 for signal transduction, but the regulatory mechanism that underlies the expression of these factors remains unclear. Here we found that the arginine methyltransferase PRMT5 was essential for the maintenance of invariant natu...
#1T. Ono (Tokyo Medical and Dental University)H-Index: 11
#2Tomoki Nakashima (Tokyo Medical and Dental University)H-Index: 36
The bone is an essential organ for locomotion and protection of the body, as well as hematopoiesis and mineral homeostasis. In order to exert these functions throughout life, bone tissue undergoes a repeating cycle of osteoclastic bone resorption and osteoblastic bone formation. The osteoclast is a large, multinucleated cell that is differentiated from monocyte/macrophage lineage cells by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL). RAN...
#1Yuki Miya (Kyoto University)
#2Yoshitaka Kameo (Kyoto University)H-Index: 9
Last.Taiji Adachi (Kyoto University)H-Index: 29
view all 4 authors...