Serotonin signals through a gut-liver axis to regulate hepatic steatosis
Abstract
Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking. Defining the key molecular pathways underlying the pathogenesis of NAFLD is essential for developing new drugs. Here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A...
Paper Details
Title
Serotonin signals through a gut-liver axis to regulate hepatic steatosis
Published Date
Nov 16, 2018
Journal
Volume
9
Issue
1
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