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Jun Namkung
KAIST
12Publications
4H-index
181Citations
Publications 13
Newest
#1Wonsuk Choi (KAIST)H-Index: 2
#2Jun Namkung (KAIST)H-Index: 4
Last.Hail Kim (KAIST)H-Index: 20
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The originally published version of this Article contained an error in Figure 2. In panel g, the image of brown adipose tissue from SCD-fed Tph1 GKO mice (top-right) was inadvertently replaced with the equivalent image of SCD-fed WT mice (top-left) during assembly of the figure. This error has now corrected in both the PDF and HTML versions of the Article.
Source
#1Jun Namkung (Yonsei University)H-Index: 4
#2Jun Namkung (Yonsei University)H-Index: 4
Last.Kyusang Park (Yonsei University)H-Index: 18
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Source
#1Wonsuk Choi (KAIST)H-Index: 2
#2Jun Namkung (KAIST)H-Index: 4
Last.Hail Kim (KAIST)H-Index: 20
view all 20 authors...
Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking. Defining the key molecular pathways underlying the pathogenesis of NAFLD is essential for developing new drugs. Here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A (HTR2A) signaling. Local serotonin concentrations in th...
7 CitationsSource
Source
#1Jun Namkung (KAIST)H-Index: 4
#2Ko Eun Shong (KAIST)H-Index: 3
Last.Hail Kim (KAIST)H-Index: 20
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Hepatic steatosis is caused by metabolic stress associated with a positive lipid balance, such as insulin resistance and obesity. Previously we have shown the anti-obesity effects of inhibiting serotonin synthesis, which eventually improved insulin sensitivity and hepatic steatosis. However, it is not clear whether serotonin has direct effect on hepatic lipid accumulation. Here, we showed the possibility of direct action of serotonin on hepatic steatosis.Mice were treated with para-chlorophenyla...
3 CitationsSource
#1Jun NamkungH-Index: 4
#2Chang-Myung OhH-Index: 4
Last.Hail KimH-Index: 5
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Source
#1Sang Kyu Park (Kwandong University)H-Index: 20
#2Jun Namkung (KAIST)H-Index: 4
Last.Seokjoon Lee (Kwandong University)H-Index: 14
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Source
#1Jun Namkung (KAIST)H-Index: 4
#2Hail Kim (KAIST)H-Index: 20
Last.Sang Kyu Park (Kwandong University)H-Index: 20
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Whole body energy balance is achieved through the coordinated regulation of energy intake and energy expenditure in various tissues including liver, muscle and adipose tissues. A positive energy imbalance by excessive energy intake or insufficient energy expenditure results in obesity and related metabolic diseases. Although there have been many obesity treatment trials aimed at the reduction of energy intake, these strategies have achieved only limited success because of their associated advers...
40 CitationsSource
#1Chang-Myung Oh (KAIST)H-Index: 3
#2Jun Namkung (KAIST)H-Index: 4
Last.Hail Kim (KAIST)H-Index: 20
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The neurotransmitter serotonin has both central and peripheral effects. Here, the authors show that adipocyte-derived serotonin regulates organismal energy homeostasis in mice by acting on adipocyte serotonin receptors on fat cells, which regulates lipolysis and thermogenesis in white and brown fat tissue.
79 CitationsSource
#1Kyuho Kim (KAIST)H-Index: 4
#2Chang-Myung Oh (KAIST)H-Index: 3
Last.Hail Kim (KAIST)H-Index: 20
view all 13 authors...
The physiological role of serotonin, or 5-hydroxytryptamine (5-HT), in pancreatic β-cell function was previously elucidated using a pregnant mouse model. During pregnancy, 5-HT increases β-cell proliferation and glucose-stimulated insulin secretion (GSIS) through the Gαq-coupled 5-HT2b receptor (Htr2b) and the 5-HT3 receptor (Htr3), a ligand-gated cation channel, respectively. However, the role of 5-HT in β-cell function in an insulin-resistant state has yet to be elucidated. Here, we characteri...
47 CitationsSource
12