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Hail Kim
KAIST
EndocrinologySerotoninInsulinHomeostasisBiology
46Publications
20H-index
1,220Citations
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Publications 52
Newest
#1Jiyoon Kim (Catholic University of Korea)H-Index: 8
#2Hyeyon Kim (Yonsei University)H-Index: 4
Last. Sowon Aum (Yonsei University)H-Index: 1
view all 17 authors...
The Golgi apparatus plays a central role in the intracellular transport of macromolecules. However, molecular mechanisms of Golgi-mediated lipid transport remain poorly understood. Here, we show that genetic inactivation of the Golgi-resident protein GRASP55 in mice reduces whole-body fat mass via impaired intestinal fat absorption and evokes resistance to high-fat diet induced body weight gain. Mechanistic analyses reveal that GRASP55 participates in the Golgi-mediated lipid droplet (LD) target...
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#1Hyunki Kim (KAIST)H-Index: 13
#2Byoung-Ha Yoon (Korea Research Institute of Bioscience and Biotechnology)H-Index: 6
Last. Hail Kim (KAIST)H-Index: 20
view all 23 authors...
Loss of functional β cell mass is an essential feature of type 2 diabetes, and maintaining mature β cell identity is important for preserving a functional β cell mass. However, it is unclear how β cells achieve and maintain their mature identity. Here, we demonstrate a novel function of PRMT1 in maintaining mature β cell identity. Prmt1 knockout in fetal and adult β cells induced diabetes, which was aggravated by high fat diet-induced metabolic stress. Deletion of Prmt1 in adult β cells resulted...
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#1Joon Ho Moon (KAIST)H-Index: 1
#2Yeong Gi Kim (KAIST)H-Index: 2
Last. Hail Kim (KAIST)H-Index: 20
view all 18 authors...
A sufficient β-cell mass is crucial for preventing diabetes, and perinatal β-cell proliferation is important in determining the adult β-cell mass. However, it is not yet known how perinatal β-cell proliferation is regulated. Here, we report that serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period. In β-cell–specific Tph1 knockout (Tph1 βKO) mice, perinatal β-cell proliferation was reduced along with the loss ...
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#1Wonsuk Choi (KAIST)H-Index: 2
#2Joon Ho Moon (KAIST)H-Index: 1
Last. Hail Kim (KAIST)H-Index: 20
view all 3 authors...
Serotonin is a biogenic amine synthesized from the essential amino acid tryptophan. Because serotonin cannot cross the blood-brain barrier, it functions differently in neuronal and non-neuronal tissues. In the CNS, serotonin regulates mood, behavior, appetite, and energy expenditure. Although most serotonin in the body is synthesized at the periphery, its biological roles have not been well elucidated. Older studies using chemical agonists and antagonists yielded conflicting results, because the...
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#1Min Jeong Choi (CNU: Chungnam National University)H-Index: 8
#2Saet-Byel Jung (CNU: Chungnam National University)H-Index: 14
Last. Minho Shong (CNU: Chungnam National University)H-Index: 38
view all 16 authors...
Mitochondrial oxidative phosphorylation (OxPhos) is essential for energy production and survival. However, the tissue-specific and systemic metabolic effects of OxPhos function in adipocytes remain incompletely understood. We used adipocyte-specific Crif1 (also known as Gadd45gip1) knockout (AdKO) mice with decreased adipocyte OxPhos function. AdKO mice fed a normal chow or high-fat diet were evaluated for glucose homeostasis, weight gain and energy expenditure (EE). RNA sequencing of adipose ti...
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#1Kanghoon Lee (KAIST)H-Index: 2
#2Hyunki Kim (KAIST)H-Index: 13
Last. Hail Kim (KAIST)H-Index: 20
view all 10 authors...
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#1Ko Eun ShongH-Index: 3
Last. Hail KimH-Index: 20
view all 3 authors...
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#1Ho Seon Park (Yonsei University)H-Index: 2
#2Hak Zoo Kim (Yonsei University)H-Index: 1
Last. Shinae Kang (Yonsei University)H-Index: 10
view all 10 authors...
Islets are highly vascularized for prompt insulin secretion. Although angiopoietin-1 (Ang1) is a well-known angiogenic factor, its role in glucose homeostasis remains largely unknown. The objective of this study was to investigate whether and how Ang1 contributes to glucose homeostasis in response to metabolic challenge. We used inducible systemic Ang1-knockout (Ang1sys-/-) and β-cell specific Ang1-knockout (Ang1β-cell-/-) mice fed a high-fat diet for 24 weeks. Although the degree of insulin sen...
1 CitationsSource
#1Wonsuk Choi (KAIST)H-Index: 2
#2Jun Namkung (KAIST)H-Index: 4
Last. Hail Kim (KAIST)H-Index: 20
view all 20 authors...
The originally published version of this Article contained an error in Figure 2. In panel g, the image of brown adipose tissue from SCD-fed Tph1 GKO mice (top-right) was inadvertently replaced with the equivalent image of SCD-fed WT mice (top-left) during assembly of the figure. This error has now corrected in both the PDF and HTML versions of the Article.
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#1Hyeongseok Kim (KAIST)H-Index: 8
#2Yeong Gi Kim (KAIST)H-Index: 2
Last. Hail Kim (KAIST)H-Index: 20
view all 10 authors...
Recent studies on tissue-autonomous serotonin (5-hydroxytryptamine [5-HT]) function have identified new roles for 5-HT in peripheral organs. Most of these studies were performed by crossing mice carrying the Tph1tm1Kry allele with tissue specific Cre mice. In the present study, we found that 5-HT production was not completely abolished in Tph1tm1Kry KO mice. The residual 5-HT production in Tph1tm1Kry KO mice is attributed to the expression of a truncated form of TPH1 containing the catalytic dom...
1 CitationsSource
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