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Hail Kim
KAIST
46Publications
20H-index
1,220Citations
Publications 50
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#1Joon Ho Moon (KAIST)H-Index: 1
#2Yeong Gi Kim (KAIST)H-Index: 2
Last.Hail Kim (KAIST)H-Index: 20
view all 18 authors...
A sufficient β-cell mass is crucial for preventing diabetes, and perinatal β-cell proliferation is important in determining the adult β-cell mass. However, it is not yet known how perinatal β-cell proliferation is regulated. Here, we report that serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period. In β-cell–specific Tph1 knockout (Tph1 βKO) mice, perinatal β-cell proliferation was reduced along with the loss ...
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#1Min Jeong Choi (CNU: Chungnam National University)H-Index: 8
#2Saet-Byel Jung (CNU: Chungnam National University)H-Index: 14
Last.Minho Shong (CNU: Chungnam National University)H-Index: 38
view all 16 authors...
Mitochondrial oxidative phosphorylation (OxPhos) is essential for energy production and survival. However, the tissue-specific and systemic metabolic effects of OxPhos function in adipocytes remain incompletely understood. We used adipocyte-specific Crif1 (also known as Gadd45gip1) knockout (AdKO) mice with decreased adipocyte OxPhos function. AdKO mice fed a normal chow or high-fat diet were evaluated for glucose homeostasis, weight gain and energy expenditure (EE). RNA sequencing of adipose ti...
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#1Hyunki Kim (KAIST)H-Index: 13
#2Βyoung-Ha Yoon (Korea Research Institute of Bioscience and Biotechnology)
Last.Hail Kim (KAIST)H-Index: 20
view all 23 authors...
Loss of functional β cell mass is an essential feature of type 2 diabetes, and maintaining mature β cell identity is important for preserving a functional β cell mass. However, it is unclear how β cells achieve and maintain their mature identity. Here, we demonstrate a novel function of PRMT1 in maintaining mature β cell identity. Prmt1 knockout in fetal and adult β cells induced diabetes, which was aggravated by high fat diet-induced metabolic stress. Deletion of Prmt1 in adult β cells resulted...
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#1Wonsuk Choi (KAIST)H-Index: 2
#2Jun Namkung (KAIST)H-Index: 4
Last.Hail Kim (KAIST)H-Index: 20
view all 20 authors...
The originally published version of this Article contained an error in Figure 2. In panel g, the image of brown adipose tissue from SCD-fed Tph1 GKO mice (top-right) was inadvertently replaced with the equivalent image of SCD-fed WT mice (top-left) during assembly of the figure. This error has now corrected in both the PDF and HTML versions of the Article.
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#1Mi-Kyoung KimH-Index: 12
#2Bo Yeon KimH-Index: 31
Last.Hail KimH-Index: 20
view all 7 authors...
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#1Ko Eun ShongH-Index: 3
Last.Hail KimH-Index: 20
view all 3 authors...
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#1Ho Seon Park (Yonsei University)H-Index: 2
#2Hak Zoo Kim (Yonsei University)H-Index: 1
Last.Shinae Kang (Yonsei University)H-Index: 10
view all 10 authors...
Islets are highly vascularized for prompt insulin secretion. Although angiopoietin-1 (Ang1) is a well-known angiogenic factor, its role in glucose homeostasis remains largely unknown. The objective of this study was to investigate whether and how Ang1 contributes to glucose homeostasis in response to metabolic challenge. We used inducible systemic Ang1-knockout (Ang1sys-/-) and β-cell specific Ang1-knockout (Ang1β-cell-/-) mice fed a high-fat diet for 24 weeks. Although the degree of insulin sen...
1 CitationsSource
#1Kanghoon Lee (KAIST)H-Index: 2
#2Hyunki Kim (KAIST)H-Index: 13
Last.Hail Kim (KAIST)H-Index: 20
view all 10 authors...
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#1Hyeongseok Kim (KAIST)H-Index: 8
#2Yeong Gi Kim (KAIST)H-Index: 2
Last.Hail Kim (KAIST)H-Index: 20
view all 10 authors...
Recent studies on tissue-autonomous serotonin (5-hydroxytryptamine [5-HT]) function have identified new roles for 5-HT in peripheral organs. Most of these studies were performed by crossing mice carrying the Tph1tm1Kry allele with tissue specific Cre mice. In the present study, we found that 5-HT production was not completely abolished in Tph1tm1Kry KO mice. The residual 5-HT production in Tph1tm1Kry KO mice is attributed to the expression of a truncated form of TPH1 containing the catalytic dom...
1 CitationsSource
#1Wonsuk Choi (KAIST)H-Index: 2
#2Jun Namkung (KAIST)H-Index: 4
Last.Hail Kim (KAIST)H-Index: 20
view all 20 authors...
Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking. Defining the key molecular pathways underlying the pathogenesis of NAFLD is essential for developing new drugs. Here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A (HTR2A) signaling. Local serotonin concentrations in th...
7 CitationsSource
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