Application of design of experiment approach for investigating the effect of partially pre-gelatinized starch on critical quality attributes of rapid orally disintegrating tablets

The objective of the current work was to enhance the critical attributes of rapid orally disintegrating tablets (RODTs) manufactured by direct compression technique to have sufficient mechanical strength and fast disintegration time using partially pre-gelatinized starch. A two factor, three levels (32), full factorial design was applied to examine the main and interaction effects of independent variables namely; partially pre-gelatinized starch...