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El-Sayed Khafagy
Suez Canal University
ChemistryCell-penetrating peptideInsulinBiochemistryPharmacology
22Publications
12H-index
825Citations
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Publications 29
Newest
Abstract In the pharmaceutical industry, the systematic optimization of formulation using Quality by Design (QbD) approach is economic, highly precise and ensures product quality. The current endeavor was aimed to prepare escitalopram ultra-fast melting tablets (UFMTs) based on QbD approach using suspension spray-coating technique. The (32) full factorial design was applied to obtain the optimal formulation in terms of; mannitol level (X1) and partially pre-gelatinized starch level (PPGS; X2) as...
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#1Passant M. Al-Maghrabi (Suez Canal University)
#2El-Sayed Khafagy (Suez Canal University)H-Index: 12
Last. Shadeed Gad (Suez Canal University)H-Index: 3
view all 4 authors...
Abstract The purpose of this study was to develop miconazole nitrate (MN) based solid lipid nano-carrier formulae for topical delivery to enhance its antifungal effectiveness. Miconazole nitrate loaded Solid lipid nanoparticles (MN-SLNs) were formulated using a high shear homogenization technique characterized by particle size, polydispersity index (PI), trapping efficiency (EE percent), drug loading (DL percent) and zeta potential (ZP) characteristics. Furthermore, the optimized formulae were i...
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#1El-Sayed Khafagy (Kobe Gakuin University)H-Index: 12
#2Noriyasu Kamei (Kobe Gakuin University)H-Index: 14
Last. Mariko Takeda-Morishita (Kobe Gakuin University)H-Index: 11
view all 12 authors...
Abstract Leptin is an endogenous hormone that regulates the appetite, energy metabolism, and glucose intake in the central nervous system (CNS) and is a potential therapeutic agent for obesity. In the normal healthy condition, peripherally secreted leptin is transported across the blood-brain barrier (BBB) to the target brain site, in particular the hypothalamus. However, it was reported that the progression of obesity causes diminished permeation of leptin across the BBB. The present study ther...
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#1Marwa H. Abdallah (Zagazig University)H-Index: 4
#2Amr S. Abu Lila (Zagazig University)H-Index: 13
Last. Mahmoud S. Soliman (Al-Azhar University)H-Index: 1
view all 6 authors...
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#2Ghada H. Elosaily (Al-Azhar University)
Last. Yasser M. Mostafa (Suez Canal University)H-Index: 2
view all 5 authors...
Purpose Timolol maleate (TMM) is a hydrophilic model drug. The aim of this study was to formulate TMM-loaded microsponges to sustain TMM release and improve its corneal permeability compared with TMM-aqueous solution.
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Purpose: This study evaluated the stereoisomeric effect of L- and D-penetratin-cell-penetrating peptides (CPPs)-incorporated insulin-loaded solid lipid nanoparticles (INS-SLNs) on the bioavailability (BA) of oral insulin (INS). Methods: Insulin-loaded solid nanoparticles, L-penetratin-INS-SLNs (LP-INS-SLNs), and D-penetratin-INS-SLNs (DP-INS-SLNs) were formulated by double emulsification. The developed SLNs were evaluated for particle size, zeta potential (ZP), and drug encapsulation and subject...
1 CitationsSource
#1Ahmed AlalaiweH-Index: 3
#2Mohamed H. Fayed (KSU: King Saud University)H-Index: 2
Last. El-Sayed Khafagy (Suez Canal University)H-Index: 12
view all 7 authors...
Abstract The objective of the current work was to enhance the critical attributes of rapid orally disintegrating tablets (RODTs) manufactured by direct compression technique to have sufficient mechanical strength and fast disintegration time using partially pre-gelatinized starch. A two factor, three levels (32), full factorial design was applied to examine the main and interaction effects of independent variables namely; partially pre-gelatinized starch level (PPGS; X1) and microcrystalline cel...
1 CitationsSource
#1Khaled M. Darwish (Suez Canal University)H-Index: 4
#2Ismail Salama (Suez Canal University)H-Index: 7
Last. Mohamed A. Helal (Suez Canal University)H-Index: 7
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Abstract Type-2 diabetes mellitus is a progressive cluster of metabolic disorders, representing a global public health burden affecting more than 366 million people worldwide. We recently reported the discovery of three series of novel agents showing balanced activity on two metabolic receptors, peroxisome proliferator activated receptor-γ (PPAR-γ) and free fatty acid receptor 1 (FFAR1), also known as GPCR40. Our designing strategy relied on linking the thiazolidinedione head with known GPCR pri...
2 CitationsSource
#1Yu Fukuoka (Hoshi University)H-Index: 2
#2El-Sayed Khafagy (Kobe Gakuin University)H-Index: 12
Last. Mariko Takeda-Morishita (Kobe Gakuin University)H-Index: 11
view all 7 authors...
6 CitationsSource
#1Noriyasu Kamei (Kobe Gakuin University)H-Index: 14
#2El-Sayed Khafagy (Kobe Gakuin University)H-Index: 12
Last. Mariko Takeda-Morishita (Kobe Gakuin University)H-Index: 11
view all 4 authors...
Abstract We have reported that cell-penetrating peptides, such as oligoarginine, act as powerful absorption enhancers for the development of oral insulin delivery systems. However, the minimal essential sequence of oligoarginine that stimulates intestinal insulin absorption remains unclear. Therefore, the present study was conducted to clarify this minimum sequence of oligoarginine and to examine the effect of single cationic amino acid arginine on the intestinal and oral absorption of insulin. ...
6 CitationsSource
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