Match!
Mohamed H. Fayed
King Saud University
ChemistryFriabilityHigh Shear GranulationChromatographyGranulation
11Publications
2H-index
12Citations
What is this?
Publications 12
Newest
Abstract In the pharmaceutical industry, the systematic optimization of formulation using Quality by Design (QbD) approach is economic, highly precise and ensures product quality. The current endeavor was aimed to prepare escitalopram ultra-fast melting tablets (UFMTs) based on QbD approach using suspension spray-coating technique. The (32) full factorial design was applied to obtain the optimal formulation in terms of; mannitol level (X1) and partially pre-gelatinized starch level (PPGS; X2) as...
Source
Abstract The poor physicochemical properties of rosuvastatin calcium (ROS) remains a challenge for dosage form development. In the present study, we explore the development of spray dried ROS loaded PVP microparticles to improve the release of ROS as well as the anti-hyperlipidemic efficacy. The ROS loaded PVP microparticles (F1–F3) were developed by spray drying method with a range of particle size (1.26–1.67 μm), PDI (0.138-0.267), PDE (78 ± 3.2 to 89 ± 4.1%), PDL and (14.8 ± 1.2 to 39.4 ± 3.3...
1 CitationsSource
1 CitationsSource
#1Ahmed AlalaiweH-Index: 3
#2Mohamed H. Fayed (KSU: King Saud University)H-Index: 2
Last. El-Sayed Khafagy (Suez Canal University)H-Index: 12
view all 7 authors...
Abstract The objective of the current work was to enhance the critical attributes of rapid orally disintegrating tablets (RODTs) manufactured by direct compression technique to have sufficient mechanical strength and fast disintegration time using partially pre-gelatinized starch. A two factor, three levels (32), full factorial design was applied to examine the main and interaction effects of independent variables namely; partially pre-gelatinized starch level (PPGS; X1) and microcrystalline cel...
1 CitationsSource
#1Bader B. AlsulaysH-Index: 6
#2Mohamed H. Fayed (KSU: King Saud University)H-Index: 2
Last. Fars K. Alanazi (KSU: King Saud University)H-Index: 23
view all 7 authors...
AbstractThe objective of this study was to examine the influence of drug amount and mixing time on the homogeneity and content uniformity of a low-dose drug formulation during the dry mixing step using a new gentle-wing high-shear mixer. Moreover, the study investigated the influence of drug incorporation mode on the content uniformity of tablets manufactured by different methods. Albuterol sulfate was selected as a model drug and was blended with the other excipients at two different levels, 1%...
Source
#1Mohamed H. FayedH-Index: 2
#2Sayed I. Abdel-Rahman (Assiut University)H-Index: 2
Last. Ramadan Al-ShdefatH-Index: 5
view all 6 authors...
AbstractThe aim of this work was to study the application of design of experiment (DoE) approach in defining design space for granulation and tableting processes using a novel gentle-wing high-shear granulator. According to quality-by-design (QbD) prospective, critical attributes of granules, and tablets should be ensured by manufacturing process design. A face-centered central composite design has been employed in order to investigate the effect of water amount (X1), impeller speed (X2), wet ma...
2 CitationsSource
#1Ali BeH-Index: 1
#2Al-Shedfat RiH-Index: 1
Last. Fars K. AlanaziH-Index: 23
view all 4 authors...
2 Citations
#1Mohamed H. FayedH-Index: 2
Last. Ali BeH-Index: 1
view all 6 authors...
Application of quality by design (QbD) in high shear granulation process is critical and need to recognize the correlation between the granulation process parameters and the properties of intermediate (granules) and corresponding final product (tablets). The present work examined the influence of water amount (X,) and wet massing time (X2) as independent process variables on the critical quality attributes of granules and corresponding tablets using design of experiment (DoE) technique. A two fa...
#1Ramadan Al-ShdefatH-Index: 5
#2Bahaa E. Ali (Al-Azhar University)H-Index: 3
Last. Gamal A. Soliman (Cairo University)H-Index: 11
view all 6 authors...
Abstract Sildenafil citrate (VIAGRA ® ) is a phosphodiasterase inhibitor 5 used for the treatment of male erectile dysfunction. Low aqueous solubility of sildenafil citrate limits their bioavailability and hence therapeutic effects. The aim of the present study was to develop a sildenafil citrate-Glycyrrhizin/Eudragit binary spray dried microparticles with a view to improve its aqueous solubility and examine its effect of sexual behavior on male rats. Microparticles of sildenafil citrate were pr...
1 CitationsSource
12