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Journal of Drug Delivery Science and Technology
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2.61
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2076
Papers 2508
1 page of 251 pages (2,508 results)
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Abstract Parkinson's disease (PD), although being the second most prevalent neurodegenerative disease (ND) encounters lack of definitive treatment and challenges in drug delivery. There are enormous factors provoking degeneration of neurons in the substantia nigra of brain that leads to symptoms of Parkinson's, such as increase in oxidative stress, overexpression of α-synuclein, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure, and many others. Among the current conventional marketed...
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Abstract Graphene has been the cornerstone material in various disciplines owing to its captivating properties. But graphene also exerts some toxic effects apart from its extraordinary characteristics. Various surface functionalizations on graphene are developed in order to overcome the toxicity. In this background, pluronics functionalization of reduced graphene oxide (rGO-P) was done as an effort to modify its toxicity. Effect of rGO-P on cerebellar granule neurons was examined to infer on its...
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Abstract Chitosan, de-acetylated form of chitin and the amino polysaccharide, is one of the most suitable biopolymer with vast possibilities of chemical modifications for novel properties and nano-medicine generations in biomedical fields. The primary amine groups in chitosan are responsible for its various properties such as cationic nature, controlled drug release, muco-adhesion, in situ gelation, antimicrobial and permeation enhancement. Chitosan nanoparticles (NPs) are commonly used as drug ...
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Abstract In this study, in order to evaluate the usability of minipigs as an experimental animal in the oral drug development process, extent and rate of oral absorption of 17 commercially drugs were investigated in minipigs and compared with those in mice rats and humans. Extent of oral bioavailability (BA) of tested drugs tended to be lower in minipigs as well as in mice and rats than in humans. From a pharmacokinetic (PK) analysis, it was revealed that the higher activity of intestinal first-...
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Abstract Diabetic nonhealing ulcers are the leading cause of nontraumatic amputations. An increased cancer risk has been found in patients treated with current therapies such as becaplermin gel. Therefore, an urgent need exists for novel approaches to control delayed ulcer healing. HIF-1α mediates adaptive responses to hypoxia by regulating angiogenesis, proliferation, migration, and cell survival. However, its function is impaired by hyperglycemia. Deferoxamine (DFO) might be an effective HIF-1...
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Abstract Copper oxide nanoparticles (CuO NPs) were fabricated by employing an easy and bio-synthetic approach utilizing peel extract of Pogestemon benghalensis (P. benghalensis) at ambient temperature. The bio-fabricated CuO NPs were studied using X-ray diffraction (X-RD), Ultra Violet- Visible absorption (UV–Vis) spectroscopy, Transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR) characterization techniques. Biosynthesized nanoparticles are crystalline in na...
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Abstract The fibrous silicates, Palygorskite and Sepiolite, were investigated as low-cost nanocarriers for three carvacrol prodrugs to ameliorate their pharmacokinetic and biopharmaceutic profiles. Adsorption equilibrium studies were performed in order to obtain a drug-clay hybrid system. These hybrid systems were characterized by thermal analysis, X-ray diffraction, and Fourier transform infrared spectroscopy, to study the degree and kind of interactions between the organic and inorganic compon...
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Abstract Causes of diabetes could be associated with many dysfunctions regarding the regulation of insulin and progression of pancreatic beta cells. Phytonanotherapy provides a symbiotic properties of metal nanoparticles and plants as they exhibit medicinal benefits which may be biologically equivalent for synthetic drugs. The present study focused on rapid and ecofriendly biosynthesis of gold nanoparticles using Eclipta alba (EA-AuNPs) and evaluated its pharmacological efficacy against pathogen...
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Abstract The protection provided by the human skin is mostly attributed to the stratum corneum. However, this barrier also limits the range of molecules that can be delivered into and across the skin. One of the methods to overcome this physiological barrier and improve the delivery of molecules into and across the skin is via the use of microneedles. This work evaluates the mechanical insertion of two different commercially available microneedle systems, Dermapen® and Dermastamp™. The influence...
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#2Conrado MarquesH-Index: 2
Last. Joyce Kelly M.C. Gonsalves (UNIVASF: Universidade Federal do Vale do São Francisco)
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Abstract Praziquantel (PZQ) is an anthelmintic drug, being the first choice for the treatment of schistosomiasis. Its high hydrophobic character and its low water solubility are the main limitations to the development of liquid formulations for the oral administration of the drug. The aim of this work was to develop Solid Lipid Nanoparticles (SLN) for the loading of PZQ for the treatment of S. mansoni infections. PZQ-SLN were produced by hot high shear homogenization. The obtained SLN exhibited ...
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