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Journal of Drug Delivery Science and Technology
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2.61
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2076
Papers 2367
1 page of 237 pages (2,367 results)
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#1A. P. S. Matos (University of Toulouse)H-Index: 1
#2A. L. Viçosa (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
Last. Carla Holandino (UFRJ: Federal University of Rio de Janeiro)H-Index: 14
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Abstract Leishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus, which affects many people in several countries. This disease has three major clinical forms: cutaneous, mucocutaneous and visceral. The current treatments consist of an intravenous, intralesional or intramuscular administration of pentavalent antimonials, but other drugs can be used, among them, amphotericin B, pentamidine, paromomycin and miltefosine. However, these therapies have many side effe...
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#1Italo Rodrigo Calori (USP: University of São Paulo)H-Index: 2
Last. Antonio Claudio TedescoH-Index: 37
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Abstract Up-regulated monocarboxylate transporters (MCTs) serve as potential targets for the development of novel therapeutic strategies against some cancer cells. Besides being an efficient substrate to some MCTs, the role of alpha-cyano-4-hydroxycinnamic acid (CHCA) as a vector of nanoparticles for cancer cells was not yet evaluated. This aim of this study was to demonstrate the role of CHCA as a vector of liposomes targeting cancer cells that overexpress MCT-1. Also, the antioxidant character...
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#1Francisco J. Peón-Díaz (UH: University of Havana)
#2Claudia Iriarte-Mesa (UH: University of Havana)
Last. Roberto Cao-Milán (UH: University of Havana)H-Index: 4
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Abstract Drug photodelivery systems are emerging as useful tools for the development of new cancer chemotherapies with reduced side effects. In this context the development of nanodevices that utilize biodegradable components are especially appealing to reduce the accumulation of exogenous materials in important organs. Here we present the development of a nanocomposite comprising copper sulfide nanoparticles (CuSNPs) covered with human serum albumin (HSA) for transporting and photorelease doxor...
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#1Wipada Samprasit (Rangsit University)H-Index: 1
#1Wipada SamprasitH-Index: 6
Last. Praneet OpanasopitH-Index: 32
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Abstract In general, a wound infection is caused by Staphylococcus aureus (S. aureus) which can be treated by antibacterial agents. Alpha mangostin (M) and resveratrol (R) have been reported to possess antimicrobial properties. However, the M and R combination has not been studied. Thus, this study aimed to develop polymer-based films for the co-delivery of M and R for the treatment of S. aureus infection. M and R were studied for their synergistic antibacterial activity against S. aureus. Vario...
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Abstract Glioblastoma Multiforme management is one the most challenging task in clinical oncology. The blood brain barrier (BBB) possesses a huge hurdle for the brain in terms of drug delivery. In a healthy brain, it performs important functions such as protecting the brain from harmful toxins by not allowing them to cross the BBB. However, in glioma, the normal composition of the BBB is disrupted which makes it difficult for the entry of drugs to the targeted site. This review provides a brief ...
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Abstract Nanofibers have unique potentials in tissue engineering, medical devices, drug delivery, diagnostics etc. due to their exceptional properties like high porosity, large surface area to volume ratio, functionality flexibility, good mechanical strength etc. Nanofibers prepared by electrospinning has grabbed the attention of many recently due to the flexibility and tailoring properties of biopolymers. Various manufacturing variables that affect the morphology of nanofibers and other process...
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Abstract Acyclovir (ACV) is an antiviral drug given as tablet that has variable and incomplete absorption from the gastrointestinal tract. Also the absorption is saturated with multi-dose regime leading to only 10-20% bioavailability. Since the drug absorption site is the upper segment of the small intestine so we hypothesised that absorption of acyclovir would increase through novel carriers such as bilosomes which are resistant to digestive enzymes disruption and offer greater drug absorption ...
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Abstract A Quality by Design approach was taken to assess the influence of several formulation parameters on critical quality attributes of liquisolid pellets (LPs) obtained by extrusion-spheronization. Two mixture experimental designs were used, one for each of the non-volatile solvents (NVS) studied: Kolliphor® EL or PEG 400. The studied parameters were the concentrations of NVS (A-Kolliphor® EL, 0–40% w/w; or PEG 400, 0–31.1% w/w), coating material (B-crospovidone, 0–50.3% w/w) and carrier (C...
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#1Guang YangH-Index: 1
#2Wei Long (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 1
Last. Yen WeiH-Index: 84
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Abstract Nanodiamond (ND) has been regarded as one of the most fascinating carbon nanomaterials for biomedical applications owing to its excellent physicochemical and biological properties. The biomedical application of ND-based materials mainly depends on its surface chemistry and properties, so the surface modification of ND is very important to improve its final biomedical application performance. In this work, a novel route for the surface modification of ND was developed via the combination...
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Abstract In the pharmaceutical industry, the systematic optimization of formulation using Quality by Design (QbD) approach is economic, highly precise and ensures product quality. The current endeavor was aimed to prepare escitalopram ultra-fast melting tablets (UFMTs) based on QbD approach using suspension spray-coating technique. The (32) full factorial design was applied to obtain the optimal formulation in terms of; mannitol level (X1) and partially pre-gelatinized starch level (PPGS; X2) as...
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