Abstract 389: Integrative genomic analyses of mutation signatures, immunogenicity and germline copy number variation of the APOBEC genes in multiple cancer types

The APOBEC-signature mutation has been frequently observed in multiple cancer types, including bladder, breast, and lung adenocarcinoma. Increased expression of the APOBEC3A and APOBEC3B genes is known to induce APOBEC-signature mutations in these cancer types. Limited studies have investigated whether the mutation patterns are associated with individual isoforms of the APOBEC3A and APOBEC3B genes, particularly the isoform uc011aoc from an...