Wei Zheng
Vanderbilt University
CancerEndocrinologyPopulationBreast cancerMedicine
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Publications 1850
#1Burcu F. Darst (SC: University of Southern California)
#2Peggy Wan (SC: University of Southern California)H-Index: 21
Last. Victoria L. Stevens (ACS: American Cancer Society)H-Index: 50
view all 72 authors...
Abstract Although men of African ancestry have a high risk of prostate cancer (PCa), no genes or mutations have been identified that contribute to familial clustering of PCa in this population. We investigated whether the African ancestry–specific PCa risk variant at 8q24, rs72725854, is enriched in men with a PCa family history in 9052 cases, 143 cases from high-risk families, and 8595 controls of African ancestry. We found the risk allele to be significantly associated with earlier age at diag...
#1Sarah S. JacksonH-Index: 6
#2Hans-Olov Adami (KI: Karolinska Institutet)H-Index: 128
Last. Gretchen L. GierachH-Index: 20
view all 43 authors...
Abstract Background Gallbladder cancer (GBC) has a female predominance, although other biliary tract cancers (BTCs) such as extrahepatic and intrahepatic bile duct (EHBDC and IHBDC) and ampulla of Vater (AVC) have a male predominance. The role of female reproductive factors in BTC etiology remains unclear. Methods We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive yea...
#1Lisa de las Fuentes (WashU: Washington University in St. Louis)H-Index: 23
#2Yun Ju Sung (WashU: Washington University in St. Louis)H-Index: 18
Last. Alisa K. Manning (Harvard University)H-Index: 39
view all 222 authors...
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects....
#1Pooja Middha Kapoor (DKFZ: German Cancer Research Center)H-Index: 1
#2Nasim Mavaddat (University of Cambridge)H-Index: 14
Last. Qin Wang (University of Cambridge)H-Index: 37
view all 143 authors...
Combining polygenic risk score (PRS) with classical risk factors could improve accuracy of breast cancer prediction models. We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors in women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overal...
#1Joyce Y. Huang (University of Pittsburgh)H-Index: 4
#2Tricia L Larose (IARC: International Agency for Research on Cancer)H-Index: 9
Last. Jian-Min Yuan (University of Pittsburgh)H-Index: 72
view all 54 authors...
Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case–control pairs from 20 prospective cohorts included in the international Lung Cancer Cohort Consortium. All biomarkers were quantified by mass spectrometry-based m...
#1Xiaofeng Lan (Guangzhou Medical University)
#2Yanling Zhou (Guangzhou Medical University)H-Index: 5
Last. Yuping Ning (Southern Medical University)
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Abstract Background Suicidal ideation (SI) is common in patients with major depressive disorder (MDD) and often related to cognitive deficits. Limited longitudinal study has shown that cognitive improvement is associated with reduced SI. However, the comparatively study in Chinese depressed patients is still absent. The objective of this study was to explore the specific cognitive deficits in Chinese MDD with SI and investigate the relationship between changes in cognition and change in SI acros...
#1Siddhartha Kar (Medical Research Council)
#2Daniel Considine (University of Cambridge)H-Index: 1
Last. Fernando Moreno Antón (Hospital Clínico San Carlos)H-Index: 5
view all 56 authors...
Familial, genome-wide association (GWAS), and sequencing studies and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer. In this study, we aimed to leverage this shared germline genetics to improve the power of transcriptome-wide association studies (TWAS) to identify candidate breast cancer and ovarian cancer susceptibility genes. We built gene expression prediction models using the PrediXcan method in 681 breast an...
Antipsychotic-induced dyslipidemia could increase the risk of cardiovascular diseases. This is a meta-analysis of randomized double-blind placebo-controlled trials to examine the efficacy and safety of adjunctive metformin for dyslipidemia induced by antipsychotics in schizophrenia. The standardized mean differences (SMDs) and risk ratios (RRs) with their 95% confidence intervals (CIs) were calculated using the random-effects model with the RevMan 5.3 version software. The primary outcome was th...
#1Dong-Bin Cai (Guangzhou University of Chinese Medicine)
#2Wei-Qu Yuan (Guangzhou University of Chinese Medicine)
Last. Wei Zheng (Guangzhou Medical University)H-Index: 105
view all 3 authors...
#1Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 11
#2Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 4
Last. Catherine M. Tangen (Fred Hutchinson Cancer Research Center)H-Index: 46
view all 45 authors...
Introduction: Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46), showed reduced performance in men with African genetic ancestry. We used a cross-validated search to identify SNPs that might improve performance in this population. Material and Methods: Anonymized genotypic data were obtained from the PRACTICAL consortium for 6,253 men with African genetic ancestry. Ten iterations of a ten-fold cross-validation se...