Wei Zheng
Vanderbilt University
Publications 1497
#1Weijian Liu (Guangzhou Medical University)H-Index: 2
#2Yanling Zhou (Guangzhou Medical University)H-Index: 4
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
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Abstract Background Recent studies have suggested that neurocognition is changed after repeated infusions of ketamine in patients with treatment-resistant depression (TRD). The objective of this study was to investigate whether differences existed in the neurocognitive effect of six ketamine infusions in patients with anxious and nonanxious TRD and to determine the association between baseline neurocognition and changes in symptoms after the infusions. Method Patients with anxious (n = 30) and n...
#1Joshua D. Hoffman (UCSF: University of California, San Francisco)H-Index: 8
#2Laura Fejerman (UCSF: University of California, San Francisco)H-Index: 16
Last.Jeffrey N. Weitzel (City of Hope National Medical Center)H-Index: 49
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Background Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report on fine mapping of the 6q25 locus in an expanded sample of Latinas.
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Karoline Kuchenbaecker (UCL: University College London)H-Index: 3
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Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
#1Zhishan Chen (VUMC: Vanderbilt University Medical Center)
#2Wanqing Wen (VUMC: Vanderbilt University Medical Center)H-Index: 51
Last.Xingyi Guo (VUMC: Vanderbilt University Medical Center)H-Index: 23
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Background Although APOBEC-mutational signature is found in tumor tissues of multiple cancers, how a common germline APOBEC3A/B deletion affects the mutational signature remains unclear.
#1Yu-Shan Cheng (NIH: National Institutes of Health)
#2Peter R. Williamson (NIH: National Institutes of Health)H-Index: 36
Last.Wei Zheng (NIH: National Institutes of Health)H-Index: 110
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Infections from multidrug resistant (MDR) pathogens and emerging viruses present challenges for effective clinical treatments. Drug repurposing and combination screens may provide therapies at a fraction of the time and cost of traditional methods of drug development. Synergistic combinations of two or three known compounds can increase therapeutic efficacy and reduce concentrations required for individual drugs, in turn, reducing the risk of drug toxicity. Using libraries of approved drugs, tra...
#1Gary C.Y. Lor (Li Ka Shing Faculty of Medicine, University of Hong Kong)
#2Harvey A. Risch (Yale University)H-Index: 72
Last.Herbert Pang (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 23
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Abstract Background Mendelian randomization (MR) analyses have been increasingly used to seek evidence of causal associations. This systematic review aims at characterizing and evaluating the reporting of MR analyses in oncological studies. Methods The PubMed database was searched to identify MR cancer studies until December 31, 2017. Two of the authors independently selected and evaluated reporting quality of the studies. Reporting quality in MR studies before 2016 and in 2016/17 was compared. ...
#1Wei Zheng (Johns Hopkins University)H-Index: 110
#2Avery Meiksin (Edin.: University of Edinburgh)H-Index: 50
Last.D. Syphers (EWU: Eastern Washington University)
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#1Chengyu Wang (Guangzhou Medical University)H-Index: 2
#2Yanling Zhou (Guangzhou Medical University)H-Index: 4
Last.Ming D. Li (MPG: Max Planck Society)
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#1Wei Jie Seow (NUS: National University of Singapore)H-Index: 10
#2Xiao-Ou Shu (VUMC: Vanderbilt University Medical Center)H-Index: 96
Last.Steven C. Moore (NIH: National Institutes of Health)H-Index: 39
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Importance Chinese women have the highest rate of lung cancer among female never-smokers in the world, and the etiology is poorly understood. Objective To assess the association between metabolomics and lung cancer risk among never-smoking women. Design, Setting, and Participants This nested case-control study included 275 never-smoking female patients with lung cancer and 289 never-smoking cancer-free control participants from the prospective Shanghai Women’s Health Study recruited from Decembe...
#1Fei Wang (SDU: Shandong University)
#2Xiang Shu (VUMC: Vanderbilt University Medical Center)H-Index: 1
Last.Xiao-Ou Shu (VUMC: Vanderbilt University Medical Center)H-Index: 96
view all 9 authors...
Importance Survival differences between male and female patients with breast cancer have been reported, but the underlying factors associated with the disparity have not been fully studied. This understanding is fundamental to developing strategies for cancer treatment and survivorship care. Objective To compare mortality between male and female patients with breast cancer and quantitatively evaluate the factors associated with sex-based disparity in mortality. Design, Setting, and Participants ...