Xiao-Ou Shu
Vanderbilt University Medical Center
Publications 1025
#1Tuomas O. Kilpelaeinen (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 31
#2Amy R. Bentley (NIH: National Institutes of Health)H-Index: 15
Last.Ioanna Ntalla (QMUL: Queen Mary University of London)H-Index: 27
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Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
#1Zhishan Chen (VUMC: Vanderbilt University Medical Center)
#2Wanqing Wen (VUMC: Vanderbilt University Medical Center)H-Index: 51
Last.Xingyi Guo (VUMC: Vanderbilt University Medical Center)H-Index: 23
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Although APOBEC-mutational signature is found in tumor tissues of multiple cancers, how a common germline APOBEC3A/B deletion affects the mutational signature remains unclear. Using data from 10 cancer types generated as part of TCGA, we performed integrative genomic and association analyses to assess inter-relationship of expressions for isoforms APOBEC3A and APOBEC3B, APOBEC-mutational signature, germline APOBEC3A/B deletions, neoantigen loads, and tumor infiltration lymphocytes (TILs). We fou...
#1Julia Butt (Duke University)H-Index: 6
#2Matthew G. Varga (UNC: University of North Carolina at Chapel Hill)H-Index: 5
Last.Kwang Woon KimH-Index: 53
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Smoking is an established risk factor for gastric cancer development. In this study, we aimed to assess prospectively the association of smoking with gastric cancer risk in 1,446 non-cardia gastric cancer cases and 1,796 controls from China, Japan, and Korea with consideration of H. pylori infection as a potential effect modifier. Applying logistic regression models stratified by study and adjusted for age and sex we found that current, but not former, smoking was significantly associated with g...
#1Yaohua Yang (Vandy: Vanderbilt University)
#2Wei Zheng (Vandy: Vanderbilt University)H-Index: 20
Last.William J. Blot (Vandy: Vanderbilt University)H-Index: 95
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Background Cigarette smoking is a common risk factor for diseases and cancers. Oral microbiota is also associated with diseases and cancers. However, little is known about the impact of cigarette smoking on the oral microbiota, especially among ethnic minority populations. Methods We investigated cigarette smoking in relationship with the oral microbiota in a large population of predominately low-income and African-American participants. Mouth rinse samples were collected from 1616 participants ...
#1Haoyu Zhang (Johns Hopkins University)H-Index: 2
#2Thomas U. Ahearn (NIH: National Institutes of Health)H-Index: 11
Last.Manjeet K. Bolla (University of Cambridge)H-Index: 27
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Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth fac...