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Obesity and Kidney Disease

Published on Jul 1, 2018in Progress in Cardiovascular Diseases 6.16
· DOI :10.1016/j.pcad.2018.07.005
Jay I. Lakkis2
Estimated H-index: 2
(U.H.: University of Hawaii at Manoa),
Mathew R. Weir1
Estimated H-index: 1
(UMB: University of Maryland, Baltimore)
Abstract Obesity is a systemic disease of the white adipose tissue, which has evolved into a global epidemic. It is associated with a plethora of adipocyte hormonal (adipokine) imbalances, dysregulation of the energy-balance system, imbalances in metabolic homeostasis, a pro-inflammatory state and multiple target organ damages. Clinically, the obesity phenotype is not homogenous and is more likely to represent a spectrum with varying degrees of metabolic un-health; metabolically-unhealthy obesity is often a part of the metabolic syndrome. The links between obesity and chronic kidney disease are numerous, bidirectional, multi-layered and complex; this complexity may be explained by shared pathophysiological pathways (e.g. chronic inflammation, increased oxidative stress, and hyper-insulinemia), shared clusters of risk factors as well as associated diseases (e.g. insulin resistance, hypertension and dyslipidemia). We will review these links and their clinical manifestations, and offer a summary of available non-pharmacological as well as pharmacological therapeutic strategies.
  • References (134)
  • Citations (2)
Published on Sep 1, 2018in The Lancet Diabetes & Endocrinology 24.54
Nathalie Eckel3
Estimated H-index: 3
(University of Potsdam),
Yanping Li43
Estimated H-index: 43
(Harvard University)
+ 3 AuthorsMatthias B. Schulze67
Estimated H-index: 67
(University of Potsdam)
Summary Background Cardiovascular disease risk among individuals across different categories of BMI might depend on their metabolic health. It remains unclear to what extent metabolic health status changes over time and whether this affects cardiovascular disease risk. In this study, we aimed to examine the association between metabolic health and its change over time and cardiovascular disease risk across BMI categories. Methods Between June and December, 1976, 121 701 female nurses were recrui...
20 Citations Source Cite
Published on Jul 1, 2018in Metabolism-clinical and Experimental 6.51
Glaucia Carneiro11
Estimated H-index: 11
(UNIFESP: Federal University of São Paulo),
Maria Tereza Zanella12
Estimated H-index: 12
(UNIFESP: Federal University of São Paulo)
Abstract Objective To analyze metabolic and hormonal disorders resulting from the association between obesity and obstructive sleep apnea (OSA) syndrome that predispose to cardiovascular diseases and investigate the clinical benefits obtained from treatment approaches for both conditions. Methods A literature review between 1997 and 2017 was conducted in the PubMed search database. Results Obesity is the most important risk factor for OSA, and the progressive increase in its prevalence also affe...
6 Citations Source Cite
Published on Jun 1, 2018in Journal of Global Health 3.08
Haifeng Hou1
Estimated H-index: 1
Yange Zhao1
Estimated H-index: 1
+ 5 AuthorsWei Wang1
Estimated H-index: 1
Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension.The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was f...
12 Citations Source Cite
Published on Apr 24, 2018in JAMA 51.27
Craig M. Hales16
Estimated H-index: 16
(CDC: Centers for Disease Control and Prevention),
Cheryl D. Fryar22
Estimated H-index: 22
(CDC: Centers for Disease Control and Prevention)
+ 2 AuthorsCynthia L. Ogden55
Estimated H-index: 55
(CDC: Centers for Disease Control and Prevention)
187 Citations Source Cite
Published on Apr 10, 2018in Circulation 23.05
Milton Packer90
Estimated H-index: 90
(Baylor University Medical Center)
Obesity (especially visceral adiposity) can be associated with 3 different phenotypes of heart failure: heart failure with a reduced ejection fraction, heart failure with a preserved ejection fraction, and high-output heart failure. All 3 phenotypes are characterized by an excessive secretion of aldosterone and sodium retention. In addition, obesity is accompanied by increased signaling through the leptin receptor, which can promote activation of both the sympathetic nervous system and the renin...
11 Citations Source Cite
Published on Apr 1, 2018in Atherosclerosis 4.25
Lora J. Kasselman3
Estimated H-index: 3
Nicholas A. Vernice2
Estimated H-index: 2
+ 1 AuthorsAllison B. Reiss27
Estimated H-index: 27
Abstract Cardiovascular disease associated with obesity and autoimmunity is the leading cause of death in these populations and significant residual risk remains despite current treatment approaches. Obesity, type 1 diabetes mellitus (T1DM), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) are linked to chronic inflammation, and subjects with these disorders have characteristic shifts in their gut microbiome composition. Recent data suggest that alterations in gut microbial and ...
25 Citations Source Cite
Published on Mar 27, 2018in Circulation 23.05
Ian J. Neeland22
Estimated H-index: 22
(UTSW: University of Texas Southwestern Medical Center),
Paul Poirier53
Estimated H-index: 53
(Laval University),
Jean-Pierre Després110
Estimated H-index: 110
(Laval University)
The prevalence of obesity has increased globally over the last 2 decades. Although the body mass index has been a convenient and simple index of obesity at the population level, studies have shown that obesity defined by body mass index alone is a remarkably heterogeneous condition with varying cardiovascular and metabolic manifestations across individuals. Adipose tissue is an exquisitely active metabolic organ engaged in cross-talk between various systems; perturbation of adipose tissue result...
46 Citations Source Cite
Published on Mar 1, 2018in American Journal of Kidney Diseases 6.65
Rajiv Saran49
Estimated H-index: 49
Bruce M. Robinson44
Estimated H-index: 44
+ 66 AuthorsPaul W. Eggers57
Estimated H-index: 57
117 Citations Source Cite
Published on Feb 23, 2018in Frontiers in Physiology 3.20
Kelsey H. Collins8
Estimated H-index: 8
(U of C: University of Calgary),
Walter Herzog67
Estimated H-index: 67
(U of C: University of Calgary)
+ 5 AuthorsDavid A. Hart50
Estimated H-index: 50
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve, while others become chronic and exert a sustained impact on the host, systemically or locally. Obesity is now recognized as a chronic low-grade, systemic inflammatory state that predisposes to other chronic conditions including metabolic syndrome (MetS). Although obesity has received considerable attention regardi...
27 Citations Source Cite
Cited By2
Published on May 1, 2019in American Journal of Preventive Medicine 4.43
Amanda E. Paluch8
Estimated H-index: 8
Amanda Paluch1
Estimated H-index: 1
(NU: Northwestern University)
+ 6 AuthorsMercedes R. Carnethon52
Estimated H-index: 52
Introduction Non-white minorities are at higher risk for chronic kidney disease than non-Hispanic whites. Better cardiorespiratory fitness is associated with slower declines in estimated glomerular filtration rate and a lower incidence of chronic kidney disease. Little is known regarding associations of fitness with racial disparities in chronic kidney disease. Methods A prospective cohort of 3,842 young adults without chronic kidney disease completed a maximal treadmill test at baseline in 1985...
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Published on May 1, 2019in Endocrine 3.30
Juan Chen2
Estimated H-index: 2
(SEU: Southeast University),
Shanhu Qiu10
Estimated H-index: 10
(SEU: Southeast University)
+ 2 AuthorsZilin Sun9
Estimated H-index: 9
(SEU: Southeast University)
Purpose Promoting urine glucose excretion (UGE) is an attractive approach for the treatment of diabetes. Obesity is associated with increased risk for type 2 diabetes. This study was aimed to investigate the association of waist-to-hip ratio (WHR), a simple measure of abdominal obesity, with UGE determined in subjects without previous history of diabetes.
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Published on Sep 10, 2018in International Journal of Molecular Sciences 4.18
David E. Bartlett1
Estimated H-index: 1
Richard B. Miller1
Estimated H-index: 1
+ 10 AuthorsPaul C. Bown1
Estimated H-index: 1
Background: Oxidant stress plays a key role in the development of chronic kidney disease (CKD). Experimental CKD leads to accumulation of uremic toxins (UT) in the circulation resulting in increased ROS production, which in turn, is known to activate the Na/K-ATPase/ROS amplification loop. Studies in a murine model of obesity have shown that increased oxidative stress in plasma is due to increased ROS and cytokine production from dysfunctional adipocytes. Therefore, we hypothesized that adipocyt...
2 Citations Source Cite