Match!
Jay I. Lakkis
University of Maryland Medical System
5Publications
2H-index
5Citations
Publications 5
Newest
#1Jay I. Lakkis (U.H.: University of Hawaii at Manoa)H-Index: 2
#2Matthew R. Weir (UMB: University of Maryland, Baltimore)H-Index: 28
Abstract Chronic kidney disease (CKD) is associated with an array of secondary abnormalities of blood cell lines: red blood cells, white blood cells, and platelets. Anemia in CKD becomes more common as CKD progresses and is associated with significant all-cause as well as cardiovascular morbidity and mortality. CKD also results in progressive platelet dysfunction and impaired primary hemostasis. Furthermore, CKD is associated with impaired immune homeostasis, with abnormalities in both innate an...
#1Jay I. Lakkis (University of Maryland Medical System)H-Index: 2
#2Matthew R. Weir (University of Maryland Medical System)H-Index: 28
This chapter provides a clinical perspective on how the kidney can be used as a sentinel for cardiovascular disease (CVD) burden and, perhaps, as a means of measuring therapeutic success for the treatment of cardiovascular disease. To accomplish these goals, we will first provide some background about the relationship between chronic kidney disease and CVD. Next, we will discuss the value of estimating glomerular filtration rate (GFR) as a better measure of overall kidney function as opposed to ...
#1Matthew R. Weir (UMB: University of Maryland, Baltimore)H-Index: 28
#2Jay I. Lakkis (U.H.: University of Hawaii at Manoa)H-Index: 2
Last.Elaine Ku (UCSF: University of California, San Francisco)H-Index: 10
view all 7 authors...
Multiple clinical trials have demonstrated that renin-angiotensin system (RAS) blockade with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers effectively reduces chronic kidney disease (CKD) progression. However, most clinical trials excluded participants with advanced CKD (ie, estimated glomerular filtration rate [eGFR] 2 ). It is acknowledged that initiation of RAS blockade is often associated with an acute reduction in eGFR, which is thought to be functional, b...
#1Jay I. Lakkis (U.H.: University of Hawaii at Manoa)H-Index: 2
#2Mathew R. Weir (UMB: University of Maryland, Baltimore)H-Index: 1
Abstract Obesity is a systemic disease of the white adipose tissue, which has evolved into a global epidemic. It is associated with a plethora of adipocyte hormonal (adipokine) imbalances, dysregulation of the energy-balance system, imbalances in metabolic homeostasis, a pro-inflammatory state and multiple target organ damages. Clinically, the obesity phenotype is not homogenous and is more likely to represent a spectrum with varying degrees of metabolic un-health; metabolically-unhealthy obesit...
#1Jay I. Lakkis (U.H.: University of Hawaii at Manoa)H-Index: 2
#2Matthew R. Weir (UMB: University of Maryland, Baltimore)H-Index: 28
Purpose of Review Hyperkalemia develops in a patient with systemic arterial hypertension (HTN) if one or more risk factors are present, namely chronic kidney disease (CKD) (especially severe stage 4-5 CKD), diabetes mellitus (DM), heart failure (HF), or pharmacological therapies that interfere with potassium homeostasis, mainly through renin-angiotensin-aldosterone inhibition (RAASi). Hyperkalemia is a considerable reason of morbidity (emergency department (ED) visits and hospitalizations) and p...
1